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Biomedical subjects

A Genton

Publications and source records attributed to A Genton.

47 records · Page 3Linked to original sources
PubMed1986

[Evaluation of a school health program for high school and gymnasium students in the canton of Vaud: methodological tools].

A pilot health school programme has been set up on an experimental way since January 1984 in a few professional and high schools of the Canton of Vaud. The paper presents the methodological tools that will allow an evaluation of various aspects of this experience, which has lasted for three years. The process will be evaluated among three populations: the pupils, the teachers and the members of the health team. The results will be evaluated in two fields: the screening of hypertension and tuberculosis on one side and the outcome of individual counseling on the other side. The paper illustrates both the utility and the difficulties linked to the setting up of such an evaluation process: it underlines the complexity of choosing indicators that are useful accessible and acceptable among the huge number of available data.

Adolescent↗
PubMed1979

[Acute arterial obstructions of the limbs in the aged].

131 cases of acute arterial obstruction were treated during 1973-1977, 70 (52%) of these cases were seen in patients of over 70 years of age and 20 out of them died during the first two months of the surgical treatment, 8 patients were amputed. The long term evaluation of 40 patients who survived for more than two months after the surgical treatment shows a very high mortality (14 of the 40 surviving patients died during the first two years of the surgical treatment). Satisfactory results were obtained in 18 patients. The long term results after arterial obstruction in old patients has high mortality and the number of amputations is directly proportional to the delay before commencement of the surgical treatment.

Acute Disease↗
PubMedDate not supplied

Use of the main tyrosine protein kinase activity purified from HL-60 in the search for a new class of anticancer compounds.

A tyrosine protein kinase (TPK) partially purified and two co-purified proteins (pp39 and pp44) from HL-60 cells were used as a basis for a SDS-PAGE electrophoresis screening test of inhibitors of the activity catalyzed by this enzyme. Such inhibitors may constitute a new class of anticancer agents. TPK is a protein of about 32 to 35 kDa as measured by gel-sizing exclusion. This enzyme is apparently the main tyrosine protein kinase from the cytosol of HL-60 cells. The test was assessed using known inhibitors of various types of protein kinases. Erbstatin and Cibcron Blue--a nucleotide analog--were shown to be potent inhibitors of TPK activity.

Antineoplastic Agents↗
PubMedDate not supplied

Resection of metastases to the alimentary tract from malignant melanoma.

Metastases to the celio-mesenteric organs from malignant melanoma are studied retrospectively in 22 autopsied cases and in seven surgically treated patients. Metastatic disease to one or more celio-mesenteric organs was found in 86.3% of postmortem examinations: the liver was the most frequently involved organ, followed by the pancreas, peritoneum, small bowel, biliary tract spleen, colon and stomach, in that order. Surgery only resulted in long-term asymptomatic survival in those patients with a long relapse-free interval and a single metastasis. It is concluded that, apart from cases with intestinal obstruction or massive GI bleeding, resection should be reserved for patients with a relapse-free interval of at least 15 months and with a single "alimentary" metastasis. It is suggested that diagnosis of systemic spread at the asymptomatic stage would improve prognosis of stage IV malignant melanoma.

Adult↗