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Biomedical subjects

A Gaucher

Publications and source records attributed to A Gaucher.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

Decrease of in vitro serum protein binding of salicylate in rheumatoid arthritis.

Free and bound fractions of salicylates were separated by equilibrium dialysis and measured by spectrofluorimetry in 27 patients with rheumatoid arthritis and in 16 controls. The results showed that in patients with rheumatoid arthritis, the binding of salicylate to proteins decreased in an overproportional manner with the decrease of serum albumin concentrations. This phenomenon was linked with the severity of the inflammatory syndrome. The saturation binding capacity per unit of protein concentration was lower in the patients suffering from active forms of the condition, a finding which suggests that the changes observed are not due only to quantitative changes in the serum albumins. This study confirms the importance of determining free salicylate concentrations in the treatment of patients with inflammatory diseases.

Adolescent↗
PubMedDate not supplied

MR patterns of dialysis arthropathy.

Ten patients (average age 51 years) on long-term hemodialysis (average duration 13.5 years) were examined by magnetic resonance (MR) (all cases) and CT (five cases) for cystic radiolucencies of the wrist, shoulders, and hips. MR and CT revealed more lesions of smaller size than plain films and both showed a constant communication with the joint space. Synovial hypertrophy was generally absent or very mild even in the case of large osseous erosions. The MR analysis of the content of the lesions in the wrist was quite variable: low signal on T1- and T2-weighted images (12 of 24), low signal on T1- and high signal on T2-weighted images (10 of 24), and high signal on T1- and T2-weighted images (2 of 24). The patterns of transplanted (four cases) or ungrafted (six cases) patients were indistinguishable. These results suggest an articular origin of the lesions, but different from synovial processes such as rheumatoid arthritis, and confirm their probable multifactorial pathogenesis.

Female↗
PubMedDate not supplied

Lymphocyte subpopulations in an experimental model of axial and peripheral enthesiopathies.

We report a study of lymphocyte subsets in experimental arthritis induced in Wistar Furth rats by native human type II collagen and muramyl dipeptide. This experimental arthritis shares similarities with both the spondyloarthropathies and rheumatoid arthritis. Peripheral blood T lymphocytes, primarily the CD4+ cells (p = 0.01), were lower in arthritic rats than in the controls, although the difference in the CD4/CD8 ratio was not statistically significant. Splenic CD4 cells were significantly (p = 0.03) more numerous in arthritic rats, while the numbers of MHC class II positive cells (p = 0.002) and kappa-bearing B-cells (p = 0.0004) were significantly lower. Determination of peripheral blood and spleen lymphocytes subsets could therefore be used for the assessment of arthritis and for the evaluation of therapeutic agents. Thymic T-cell differentiation does not appear to be impaired in this model. These results differ from the peripheral blood disturbances described in the active stages of human rheumatoid arthritis and are more similar to those reported in ankylosing spondylitis patients. However, the absence of alterations in the Peyer's patches suggests that pathogeneic mechanisms involving mucosal areas and exogenous intestinal antigens are not reproduced in this model.

Acetylmuramyl-Alanyl-Isoglutamine↗
PubMedDate not supplied

Influence of sulfasalazine on established collagen arthritis in rats.

Collagen induced arthritis (CIA) in rats is an experimental model that is characterized by an erosive synovitis associated with periostitis and both peripheral and axial ossifying enthesopathy. The influence of long-term therapy with sulfasalazine (80 mg/day on weekdays) on established CIA in Wistar Furth rats was investigated. Clinical and X-ray examination showed a significant improvement in the joint lesions of the uninjected paws in the treated rats as compared to controls. This effect was, however, delayed. On the other hand, periosteal new bone formation and caudal enthesopathy (spondylodiscitis) were not altered by the treatment.

Animals↗
PubMedDate not supplied

[Fractures caused by bony insufficiency of the sacrum. Clinical, radiographic, scintigraphic and x-ray computed tomographic symptomatology].

Fracture of sacrum due to bone deficiency is not a rare lesion and must be considered as a possible differential diagnosis of unexplained pelvic region pain. The various clinical semeiology elements are discussed in relation of 20 cases, together with circumstances of onset, enabling definition of a population at risk: elderly women with a bone metabolic disorder and/or a congenital or acquired architectural anomaly. Radiographic, scintigraphic and CT scan images are sufficiently characteristic for these non-invasive exploratory procedures to provide an exact diagnosis and the possibility of early treatment.

Aged↗
PubMedDate not supplied

The diagnostic value of 99m Tc-diphosphonate bone imaging in transient osteoporosis of the hip.

We present topographic and quantitative studies of 99m Tc-diphosphonate bone scans from 46 patients and 25 control subjects in which we found transient osteoporosis of the hip (TOH) (12 cases--2 bilateral), early aseptic osteonecrosis of the femoral head (19 cases--2 bilateral), early coxitis (11 cases), and stress fracture of the femoral neck (4 cases). Active TOH was characterized by intense, homogeneous increased uptake of the entire femoral head, extending to the acetabulum and the neck, and sometimes to the shaft. The scintigram of TOH differed greatly from that in the other hip disorders studied. Bone scintigraphy can help to diagnose the cause of pain in a hip before definite roentgenographic signs appear.

Adult↗