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Biomedical subjects

A Garcia

Publications and source records attributed to A Garcia.

At least 343 records · Page 19Linked to original sources
PubMed1979

[Postoperative haemodynamic evaluation of myocardial protection by physicochemical cardioplegia. Hyperkaliemic, hyperosmolar and acid solution at 4 degrees C (author's transl)].

Myocardial protection by a combination of cardiac hypothermia and chemical cardioplegia (high concentration of K+ and Mg++, hyperosmolarity, acid pH), was studied during 20 valve replacements. Essentially assessed on the basis of repeated measurements of postoperative cardiac output, the results were compared with those obtained previously using local hypothermia only (20 patients) and hypothermic cardioplegia using Ringer Lactate (20 patients). Analysis of haemodynamic data, which thus involved 60 patients, indicated the superiority of physicochemical cardioplegia, and this for clamping periods of up to 2 hours, but also showed the desirability of changes in the protection protocol during the ischaemia phase and during reperfusion which might improve the results.

Cardiac Output↗
PubMed1979

[Anesthesia and intensive care during aorto-coronary bypass surgery. Prospective study of 162 consecutive cases].

The authors studied a series of 162 patients undergoing surgery for aorto-coronary bypass by saphenous graft. In each case, the anesthetic technique was classical neuroleptanalgesia. Per and postoperative care included standard water and electrolyte balance, hpeparinisation from the 12th hour and routine prophylactic antibiotics. In addition, special treatment was given whenever necessary: vasodilators, essentially IV nitroglycerine; catecholamines; anti-arrhytmic agents; intra-aortic counter pulse balloon. The autors evaluate the effects of the use of these different types of treatment, in particular on electrocardiographic abnormalities and haemodynamic complications and analyse peri-operative mortality and morbidity.

Anesthesia↗
PubMed1977

Irradiation lesions of the growth plate in rabbits.

The effects of gamma irradiation on the growth plate have been studied in nineteen rabbits with a 1,000 rads/skin dose. The rabbits were killed after one to ninety days. The growth plates were studied by microscopic examination, thymidine-H3 autoradiography, and fluorescence with radiographic measurement. Changes were already detected after twenty-four hours at the cell mitosis level, which showed the sensitiveness of the chondrocyte itself. The lesions were clearly seen with the optical microscope after seven days, and they were most advanced between the fourteenth and twenty-first day after irradiation. Regeneration of the cartilage began in the fourth week and the histological appearance became normal after seventy days. Fluorescence with tetracycline showed a temporary retardation of growth, with consequent shortening of the affected limb.

Animals↗
PubMed1976

Lung lamellar bodies lack certain key enzymes of phospholipid metabolism.

Palmitoyl CoA-glycerol-3-phosphate acyltransferase, phosphatidate phosphohydrolase, and phospholipase A were assayed in subcellular fractions of rat lung, including lamellar bodies, the putative site of storage and secretion of lung surfactant. The specific activity of each of these enzymes in lamellar bodies was relatively low and could be entirely accounted for by a small contamination of the lamellar bodies fraction by microsomes, as quantitated by the presence of the microsomal marker reduced triphosphopyridine nucleotide cytochrome c reductase. These data indicate that lamellar bodies are not the site of synthesis of the lipid component of pulmonary surfactant by pathways involving these enzymes.

Acyltransferases↗
PubMed1975

Inguinal hernia: a common problem of premature infants weighing 1,000 grams or less at birth.

Thirty percent of 37 consecutive surviving premature infants weighing 1,000 gm or less at birth were noted to develop inguinal hernias. Incarceration occurred in two infants. One infant suffered a cardiac arrest during repair of the hernia. In view of the increased survival now being reported in these tiny prematures, it is important that physicians recognize the high incidence and potential hazards of this congenital anomaly in surviving premature infants weighing 1,000 gm or less at birth.

Birth Weight↗