Li-Fraumeni syndrome and osteosarcoma of the maxilla.
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Biomedical subjects
Publications and source records attributed to A Garcia Garcia.
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PURPOSE: This study evaluated trismus and pain after removal of impacted lower third molars and investigated whether these responses were related to difficulty of surgery. PATIENTS AND METHODS: A consecutive series of 104 patients, all of whom underwent removal of an impacted lower third molar under local surgery, was studied. Difficulty of surgery was evaluated on a modified version of the Parant scale: I, extraction with forceps only; II, extraction by ostectomy; III, extraction by ostectomy and coronal section; IV, complex procedures. Trismus was evaluated in terms of maximum interincisal distance (MID) 1 and 5 days after surgery. Pain was evaluated on the basis of reported analgesic use 1 and 5 days after surgery. RESULTS: Among group I subjects, mean day 1 MID did not differ significantly (P > .05) from mean presurgery MID, whereas mean day 1 MID in groups II, III, and IV was significantly lower than before surgery. In groups II, III, and IV, mean day 5 MID remained lower than before surgery. The proportion of group I patients using analgesics was significantly lower on both days 1 and 5 than the proportion of patients using analgesics in groups II, III, and IV. In all groups, the proportion of patients using analgesics dropped significantly between days 1 and 5. CONCLUSION: Trismus is less severe after simple (forceps-only, grade I) extractions than after surgical extractions (grades II to IV). However, trismus severity after surgical extraction does not depend on difficulty of surgery. Pain, as revealed by reported analgesic use, is likewise less severe after simple extractions. Regardless of extraction type, pain declines between days 1 and 5 postsurgery.
We studied five patients who developed evidence of acute mainly motor peripheral polyneuropathy complicating a condition of prolonged sepsis associated with multi-organ failure. In the electrophysiological studies we observed normal motor and sensory nerve conduction velocities but there were drops in the amplitudes of the compound action potentials in the muscles and sensory peripheral nerves as well as high denervation activity on electromyography. Analytical studies of cerebrospinal fluid and blood did not show any findings of interest except for a deterioration in the nutritional parameters without specific deficiencies. The immunological and microbiological studies failed to determine factors related to the development of polyneuropathies. Nerve and muscle biopsies showed axonal neuropathy with some demyelination changes and reinnervation. Three patients survived the critical state and were re-examined presenting a moderate improvement in the neurological condition accompanied with signs of reinnervation in the electromyographic study. Given the absence of known factors implicated in the development of acute polyneuropathies in our patients, we suggest that the relevant disorders of the cellular metabolism observed in patients with prolonged sepsis aggravated by the defective nutritional condition, may be factors related to the development of these polyneuropathies.
Ten patients with benign familial chronic pemphigus (BFCP) (Hailey-Hailey disease) were evaluated; semiologic and localization differences were described, and special attention was given to solitary or atypical forms. In all the cases, the diagnosis was confirmed by histopathology; some histopathologic differences and the results achieved by direct immunofluorescence of skin are discussed. Most of the patients responded to the treatment with corticosteroids and antibiotics.
Scleroderma of rare appearance in children appears in minor scale as to the five per cent on the whole incidence of this collagen disease. The children usually present localized scleroderma and at times associated with other pathologies, traumatisms and injections were referred. Two patients aged 5 and 13 years old are presented, both with nodular lesions on anterolateral thigh area, and in the right buttock respectively. The patches of a side bigger than the palm of hand were only touchable and the skin that covered them only showed a slight hyperpigmentation in the edge in one of the cases. The limits were not precise and the nodulose surface was irregular. The evolution was as of two and three years, right after inoculation of antitetanical vaccination and puncture thorn of Yuca leaves. The histological control showed intensive phenomenons of fibrohyalinosis covering almost all the dermis. The studies of the laboratories didn't produce interesting data. The histological and clinical set of symptoms shows differences with the esclerodermic like states as a consequence of excipient of vitamin K, B 12, norhydroxprogesterone and anti-tetanic serum, in which they settle in the cellular subcutaneous tissue and they involution spontaneously. There are also differences with the paniculitis artefacta and with the lincar morphea associated to bifid spine. At last the authors make special mention of the case described by Desmons of progressive linear scleroderma right after the triple vaccination. The nodular or subcutaneous scleroderma is a clinical form in which the histological alteration decays in deep dermis and superficial hypodermis. The cases shown suggest a conection between a previous traumatism and the nodular scleroderma.
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We developed an acoustic study implemented throughout a neighborhood of Valencia (Spain). Acoustic recordings were made during the months of November and December 1989, on workdays between 9 a.m. and 1 p.m., and between 5 p.m. and 8 p.m. We also directly interviewed individuals living in this city area to determine their perception of noise and to evaluate the discomfort caused by it in daily life. A personal interview in the form of a questionnaire was employed to poll the neighborhood inhabitants on the magnitude of environmental noise and the distress it caused. The results showed that 40% of those interviewed considered environmental noise to cause considerable distress. On a 1 to 10 scale, over half of those interviewed rated noise in the neighborhood of 5 or higher. Traffic was considered the major source of noise, followed by noise from neighbors and factories. Of those interviewed, 9% changed the location of their bedroom as a result of noise, whereas 11% were forced to sleep with the windows closed for the same reason.