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Biomedical subjects

A Ganesan

Publications and source records attributed to A Ganesan.

44 records · Page 3Linked to original sources
PubMed1975

Distribution of pyrimidine dimers during postreplication repair in UV-irradiated excision-deficient cells of Escherichia coli K12.

During postreplication repair in excision-deficient mutants of Escherichia coli K-12, pyrimidine dimers are gradually lost from UV-irradiated DNA. Our data indicate that dimers are transferred, by a process which may involve genetic exchange, into daughter strands made after irradiation. Dimer transfer appears to continue through several rounds of replication, resulting in the gradual dilution of dimers into successive generations of DNA molecules.

Binding Sites↗
PubMedDate not supplied

A selenide linker for "traceless" solid-phase organic synthesis.

4-Bromophenethyl alcohol was protected as the THP ether, followed by reaction with magnesium and selenium to give the corresponding diselenide. Ether deprotection provides a diselenide diol, which is attached to solid-phase resins. The polymer-bound selenide anion is then generated, and functions as a traceless linker for electrophiles such as alkyl halides.

Organic Chemicals↗
PubMedDate not supplied

Total synthesis of the fumiquinazoline alkaloids: solid-phase studies.

We have previously described an efficient four-step synthesis of the fumiquinazoline alkaloids (Wang, H.; Ganesan, A. J. Org. Chem. 1998, 63, 2432-2433). Here, we demonstrate that this route is readily adaptable to combinatorial synthesis on solid phase. Linear tripeptides containing a central anthranilate unit were assembled on the Wang resin and subjected to dehydration and cyclative release to yield the pyrazino[2,1-b]quinazoline-3,6-diones in high purity. To demonstrate the scope of this protocol, a small library [ca. 20 compounds] of unnatural analogues was prepared by parallel synthesis.

Alkaloids↗
PubMedDate not supplied

Reproducibility and validity of an interviewer-administered semi-quantitative food frequency questionnaire to assess dietary intake of urban adults in southern India.

We report on the reproducibility and validity of a food frequency questionnaire (FFQ) developed for southern India. One hundred and two adult subjects aged > or =20 years drawn from the Chennai Urban Rural Epidemiology Study participated. The FFQ was developed based on local foods and habits, and was administered three times at 0, 6 and 12 month periods (called FFQ1, FFQ2 and FFQ3) to assess the reproducibility. To test the validity of the FFQ, multiple 24-h recalls collected at 2-monthly intervals for a period of 1 year and the estimated energy intake/basal metabolic rate (EI/BMR) ratio were used. The 'EpiNu' in-house food and nutrient database was used to compile dietary intakes, which were analyzed for statistical analysis. The intraclass correlation coefficient for all three FFQs ranged from 0.72 for carbohydrates to 0.45 for folate. The de-attenuated Pearson correlation for the energy adjusted nutrients between FFQ3 and 24-h recalls ranged from 0.73 for carbohydrates to 0.35 for calcium. Bland and Altman plots for energy intake between the two methods showed the limits of agreement ranged from 768 to -1358 calories/day (+/-2 standard deviations). Misclassification was low for most of the nutrients. Under-reporting of the energy intake (EI/BMR ratio<1.2) was higher in females than males. This FFQ appears to be a robust tool to measure dietary intakes in southern India.

Adult↗