Biomedical subjects

A Gandjour

Publications and source records attributed to A Gandjour.

At least 37 records · Page 2Linked to original sources

PubMed1999

Review of quality-of-life evaluations in patients with angina pectoris.

Patients with angina pectoris have a reduced quality of life because of their symptoms, impaired activity and anxiety. However, there is no consensus on the best method of measuring quality of life. A systematic literature search of randomised controlled trials (RCTs) in angina showed that the most common generic questionnaire was the Nottingham Health Profile (NHP) Part 1, and the most common angina-specific measure was the Quality-of-Life after Acute Myocardial Infarction Questionnaire. A comparison of NHP scores with those of the healthy population revealed that patients with angina particularly seem to experience a lack of energy, poor sleep and decreased physical mobility. In the RCTs evaluated, antianginal drugs did not show a significant benefit over placebo in terms of quality of life. As a result of a lack of valid data from RCTs, a strong conclusion regarding the impact of revascularisation procedures on quality of life could not be derived.

Angina Pectoris↗

PubMed1994

Effects of prostaglandins on [Ca2+]i and adenylate cyclase activity in isolated porcine gastric mucous cells.

In porcine gastric mucous cells, isolated enzymatically from the fundic mucosa and enriched by counterflow centrifugation, PGE2 (1 microM) increased adenylate cyclase activity to 225% and, distinct from that documented for other species, also [Ca2+]i, measured fluorimetrically with Fura2/AM, in Ca(2+)-containing and Ca(2+)-free incubation medium to 182% and 165% of control values, respectively. PGF2 alpha, PGD2, the stable prostacyclin analogue iloprost and the thromboxane-mimetic U46619 had no significant effects on adenylate cyclase activity and [Ca2+]i. Histamine (10 microM) stimulated adenylate cyclase activity to 236% of control value, an effect which could be blocked by the H2-receptor antagonist ranitidine. However, histamine and the activators of the cAMP system forskolin and dibutyryl cAMP had no significant effect on [Ca2+]i, indicating that an activation of the adenylate cyclase/cAMP system per se does not result in an increase in [Ca2+]i. These data suggest that prostanoids stimulate adenylate cyclase activity and [Ca2+]i in gastric mucous cells via activation of EP-receptors linked to both second messenger systems.

Adenylyl Cyclases↗

PubMed1981

[Coronary artery diseases in infants and children. A review].

Coronary artery disease of infants and children are reported. The paper deals with congenital coronary anomalies which appear either isolated or in combination of cardiac or vascular malformations. Acquired coronary diseases appear with periarteriitis nodosa, Kawasaki syndrome, arteriopathia calcificans and infantile arteriosclerosis. It is referred to etiology, clinical symptoms and therapy for each group of coronary disease with an emphasis on prevention.

Aortic Coarctation↗

PubMed1978

[Campomelic syndrome (author's transl)].

A female premature infant with dwarfism, peculiar facial features, cleft palate and bone anomalies including bowing of the lower extremities with pretibial skin dimpling, the so called "campomelic syndrome" is presented. Other symptoms were hypotonia and respiratory distress. The radiological and autopsy findings in this child are described. The lack of known teratogenic factors during the pregnancy and the available data about the familial occurance of this malformation syndrome suggest the possibility of an autosomal recessive mode of inheritance in this patient. This is the first case of campomelic syndrome reported from Iran.

Abnormalities, Multiple↗

PubMed1976