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Biomedical subjects

A G Zolotkov

Publications and source records attributed to A G Zolotkov.

At least 19 recordsLinked to original sources
PubMed2006

[Role of radiotherapy of lung cancer].

Data on the 3-year end results of radiotherapy of inoperable localized nonsmall-cell lung cancer (286) and 5-year (98)--for chemoradiotherapy are compared. Three-year survival after hyperfractionated radiotherapy was 23.7% as compared with 11.3% when standard procedures were used. Five-year survival after hyperfractionated radiotherapy using dose escalation, induction consolidation chemotherapy with iphosphamide, etoposide, cisplatin or carboplatin rose from 3.8 to 24%, while patients were discharged 2-3 weeks earlier.

Adult↗
PubMed2003

[Accelerated fractionation regimens in radiotherapy of inoperable non-small-cell lung cancer].

The results of definitive radiation treatment (1988-2000) for 375 patients with inoperable non-small cell lung cancer were analyzed. Three regimens of fractionation were used: (1) accelerated fractionation (AF)--(133), 2.5 Gy, 3 days a week, to a total of 47.5--55 Gy; (2) accelerated hyperfractionation (AHF)--(93), 1.25 Gy, daily, to a total of 60-72.5 Gy and standard fractionation (SF)--(149), 2 Gy, daily, to a total of 58-68 Gy. The advantages of AHF were established as regards complete regression rate (54.9% vs. 18.6%--SF and 18.1%--AF; p(0.001), median survival (30.5(2.4 months vs. 18.9 (1%--SF (p = 0.004) and 20.4 (2.4--AF (p = 0.004)), and 3-year survival (36.6% vs. 16.7%--SF (p = 0.005) and 15.5%--AF (p = 0.005). 17.9%, 9.0% (p = 0.11) and 8.1% (p = 0.08) have survived, respectively. Overall survival in the AHF group was superior in stages IIB--III; in stage I, the results were identical. Immediate response to radical radiotherapy appeared the only statistically significant factor of survival (p = 0.005-0.008) in all the groups.

Adult↗
PubMed2003

[Choice of fractionation regimen in radiotherapy of inoperable esophageal cancer].

The results of definitive radiation treatment for 303 patients with inoperable esophageal cancer were analyzed. Four regimens of fractionation were used: (1) accelerated hyperfractionation (AHF) (70)--1.3 Gy, twice a day, 5 weeks, to a total of 57.2-70 Gy; (2) AHF (49)--1.5-d = 1.5 Gy to a total of 54-63 Gy; (3) AHF (37)--1.7-d = 1.7 Gy to a total of 56.1-57.83 Gy and (4) standard fractionation (SF) (147) to a total of 58-70 Gy. The complete regression rate in the AHF groups (1.3-1.7, 69, 61 and 73%, respectively) was significantly higher than in that of SF (38%) (p(0.01); the median survival in the AHF groups and SF--21, 22, 12.3 and 14.3 months, respectively, and the 5-year survival 14, 12, 4 and 0%, respectively; all the differences in the groups 1.3 and SF were significant. The common independent prognostic factors for all patients were age (p = 0.04), immediate effect of radiation therapy (p = 0.01) and the length of tumor (p = 0.02).

Adult↗
PubMed1986

[Radiation injuries in patients with lymphogranulomatosis in prolonged clinical remission].

The paper is concerned with a study of long-term side effects following radiation therapy in Hodgkin's disease patients with a complete clinical remission. A total of 98 patients (the 1st group) received betatron radiation-split course in 1973-1979 and 68 patients (the 2nd group) received gamma-therapy continuous course in 1968-1974. It was shown that radiation injuries in the 1st group were less frequent. Their development was influenced by a volume of irradiated tissues, the value of a total focal dose and a significant duration of the patients' life. The frequency of radiation injuries was insignificant as compared to the number of the cured patients or the patients fit for further work and studies.

Adolescent↗
PubMed1986

[Improvement of practical training of students in clinical radiology].

Proceeding from the main purposes of teaching clinical radiology to students, the authors developed and tested methods of practical studies to form habits and skills in designing a scheme of radiation therapy of cancer patients and in predicting radiotherapeutic results and probable radiation reactions and injuries.

Education, Medical↗
PubMed1985

[Twice-daily irradiation of patients with rectal cancer].

Moving sectoral irradiation was given to 40 patients with primary (23) and recurring (17) rectal tumors. The patients received treatment 3 times a week by 2 daily fractions of 2.5 Gy with 4 h intervals. Better short-term results in primary and recurring tumors and the reduction of therapy duration were shown in comparing these patients with the control group of patients who were irradiated for 5 days a week by a single dose of 2 Gy.

Adult↗
PubMed1984

[Radiotherapy in degenerative-dystrophic and inflammatory diseases of the osteoarticular system].

Analysis of a 3-6-year follow-up of 565 patients with deforming arthrosis, spondylosis, osteochondrosis, spondylarthrosis and calcareous bursitis indicates the efficacy of the proposed standardized complex of topometric and roentgenotherapeutic methods. Medical and social rehabilitation was achieved in most of the patients. The quantitative assessment of the therapeutic results makes it possible to interpret them objectively and unambiguously.

Adult↗