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Biomedical subjects

A G Reeves

Publications and source records attributed to A G Reeves.

At least 37 records · Page 2Linked to original sources

Release from central auditory competition in the split-brain patient.

We used dichotic digits (DD), staggered spondaic words (SSW), and frequency patterns (PATT) to study central auditory function before and after two-stage callosotomy. Preoperatively, the patient demonstrated reduced scores bilaterally on all these tests, consistent with documented bilateral hemisphere lesions. After the first operation (sectioning the posterior half of the corpus callosum), the dichotic tests (DD and SSW) revealed the expected decrease in left-ear scores, but there was improvement on the right, perhaps because there was release from central auditory competition. Our findings also suggest that the "auditory" portion of the corpus callosum may be in the posterior half of this structure.

Adult↗

Interhemispheric commissurotomy for congenital hemiplegics with intractable epilepsy.

Five patients with congenital hemiplegia and intractable epilepsy had interhemispheric commissurotomy (the split-brain operation). After intervals of 2 to 12 years, the response has been excellent in four cases. One patient had moderate benefit. There were no late complications. Commissurotomy seems to be substantially better than hemispherectomy for this syndrome.

Adolescent↗

Pursuit gaze and the occipitoparietal region. A case report.

A patient lost smooth pursuit gaze to the side opposite a right occipitoparietal hemorrhage. Saccadic gaze was preserved. Pursuit gaze broken by saccades was present toward the side of the lesion. Optokinetic nystagmus (OKN) was defective when a tape was moved toward the patient from the hemianopic fields. Within two weeks, the contralateral pursuit gaze defect had cleared; however, the visual field and OKN defects and the ipsilateral pursuit gaze abnormality persisted.

Aged↗

On the notion of doll's eyes.

The descriptor doll's eyes is used (and sometimes abused) in reporting clinical signs at the bedside. Originally coined by Bielschowsky, its meaning is often compromised by prior experience with dolls that exhibit human pathology as part of their normal condition. Radiographic examination of antique dolls provides insight into their mechanism of horizontal conjugate gaze, a function rarely encountered in contemporary dolls.

Brain↗

Forebrain commissurotomy for epilepsy. Review of 20 consecutive cases.

During the past 10 years, 20 patients with intractable generalized, generalized and partial, and partial seizures have been treated here by surgical division of one or more of the forebrain commissures. Modifications in the operative technique and extent of operation have resulted in continued good results in seizure control with decreased morbidity. The present operation, a two-stage division of the corpus callosum and underlying hippocampal commissure, is demonstrated to be effective in controlling intractable seizures. Good or excellent results account for more than 80 per cent of the series. Historical background, indications for operation, criteria for patient selection, operative technique, results, complications, and the value of forebrain commissurotomy as a research tool are presented.

Adolescent↗

Depth electrode recording in patients undergoing corpus callosotomy for intractable epilepsy.

6 patients undergoing anterior corpus callosotomy for intractable epilepsy have been studied with depth electroencephalography (EEG). Recording before, during and after surgery has confirmed the ability of depth EEG to demonstrate and identify lateralized, focal and often multifocal disturbances. Callosal section has an immediate and lasting effect on clinical seizures and is accompanied by EEG changes with loss of generalization and synchrony following commissurotomy. Depth electrodes within the corpus callosal radiations variably reflect preoperative epileptiform activity recorded from the temporal and frontal regions and postoperatively confirm loss of a potential route of propagation through the commissure.

Adolescent↗

"Central" commissurotomy for intractable generalized epilepsy: series two.

A second consecutive series of 12 patients underwent microsurgical "central" commissurotomy (division of the entire corpus callosum and hippocampal commissure) for the relief of previously intractable generalized seizures. This modified operation was found to be safer than the multiple commissurotomies performed in the first series of eight patients and was equally effective. Central commissurotomy was modified further by being performed in two stages, which reduced the length and severity of the "acute disconnection syndrome," a common cause of morbidity in the early postoperative phase. Best results were obtained in patients who were not severely retarded, had signs of unilateral cerebral damage, and included akinetic spells as a prominent form of their generalized seizures. EEG showed that bilateral symmetric discharge became either unilateral or asymmetric after surgery, which emphasized the important role played by the corpus callosum in conducting seizure discharges from one hemisphere to the other.

Adolescent↗

Pediatric cerebellar infarction: case report and review of the literature.

Infarction in the vertebrobasilar system is uncommon in children. Cerebellar infarction presenting as a posterior fossa mass lesion is distinctly rare. We recently treated a 13-year-old boy with such a lesion as a complication of basilar artery migraine. A review of the literature on vertebrobasilar infarction in children is presented and the therapeutic alternatives in cerebellar infarction are discussed.

Adolescent↗

Staged commissurotomy and central auditory function.

Two young right-handed men with normal peripheral hearing underwent a "staged" commissurotomy procedure. At the first surgical setting, approximately the posterior half of the corpus callosum was sectioned. Approximately two months after the first operation, the remaining portion was surgically disconnected. Extensive central auditory assessment indicated little deficit after each surgery, which was not the case in previous data on patients with commissurotomy at one setting. We discuss possible mechanisms for these differing results, along with the advantages of the staged surgical procedure.

Adult↗

Bilateral rhinocerebral phycomycosis.

A 51-year-old diabetic woman developed bilateral rhinoorbitocerebral phycomycosis. Successful treatment was accomplished by correction of the ketoacidosis, surgical debridement, and amphotericin B therapy. Rhinoorbitocerebral phycomycosis is a fulminant and frequently fatal disease most often seen in debilitated hosts. This survival suggests that aggressive therapy is indicated in patients with extensive fungal involvement.

Amphotericin B↗