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Biomedical subjects

A G Oparin

Publications and source records attributed to A G Oparin.

16 recordsLinked to original sources
PubMed2005

[Oxidative stress in mechanism of psychosomatic disorders realization in duodenal ulcer in students].

AIM: To study the role of oxidative stress in mechanism of psychosomatic disorders involvement in pathogenesis of ulcerogenesis. MATERIAL AND METHODS: Psychosomatic disorders (PSD) and oxidative stress (OS) were assessed in 120 students with duodenal ulcer (DU) who had no concomitant pathology. Examination for PSD included interviewing by questionnaires. OS was judged by the level of lipid peroxidation products (malonic dialdehyde and dienic conjugates) and antioxidant activity--by glutathion peroxidase and superoxidedismutase. Melatonin was measured by enzyme immunoassay. RESULTS: A close correlation was discovered between the severity and features of PSD, lowering of melatonin, severity of OS and clinical features of the disease. CONCLUSION: DU students develop PSD which become leading factors of ulcerogenesis. One of the mechanisms of their participation in ulcerogenesis may be related with lowering of melatonin which is a potent stress regulator and corrector of lipid peroxidation and antioxidant activity.

Adolescent↗
PubMed2002

[Endothelial dysfunction in pathogenesis of duodenal ulcer].

It is shown that in patients with ulcer associated with Helicobacter pylori (HP) there is a close correlation between the severity of the lesion of gastroduodenal protective mucous barrier and that of endothelial dysfunction manifesting in elevated level of endothelin-1, serum levels of TBK-active products, inhibition of blood flow and narrowing of the celiac trunk. The correlation becomes stronger with expanding contamination of gastroduodenal mucosa with HP. Thus, HP may participate in breaking the protective mucous barrier in endothelial dysfunction.

Adolescent↗
PubMed1993

[The role of biliary dyskinesia in the mechanism of the damage to the protective properties of the mucosal barrier in peptic ulcer].

Mucous barrier resistance was studied in 232 duodenal ulcer patients with signs of exacerbation as shown by PAS-positive substances and acid mucopolysaccharides in antral mucosa of the stomach and duodenum as well as by gastric juice levels of gastromucoproteins, fucose and sialic acids. In addition, measurements were performed of biliary motility. The tests indicated that half of the ulcer patients developed biliary dyskinesia manifesting as hyperkinesia or hypokinesia. The resultant decrease in gastric mucins requires individual correction.

Adult↗
PubMed1991

[The biochemical composition of the bile and the function of the protective mucosal barrier in peptic ulcer patients].

The state of the protective mucosa barrier was studied in 87 patients with ulcer disease by means of determination of the level of PAS-positive substances and acid mucopolysaccharides in the gastric and duodenal mucosa. It was found that changes of the biochemical composition of the bile produced an essential influence on the reduction of protective properties of the gastroduodenal mucosa barrier, especially in the presence of gastroduodenal reflux.

Adult↗
PubMedDate not supplied

[The use of nifedipine in gastric and duodenal peptic ulcer].

It has been ascertained that use of nifedipine in antiulcer therapy is justified from the clinical standpoint as well as pathogenetically substantiated since its incorporation into the complex of therapeutic measures designed to treat patients with ulcer disease makes for a speedier cicatrization of ulcers as well as augmentation of the gastric mucose levels of periodic acid-Schiff reaction-positive substances and acid mucopolysaccharides, dispelling of hyperthermia foci, increase in bioelectric potentials and activation of motion of nuclei of epithelial cells of the pyloric portion of the stomach.

Adult↗