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Biomedical subjects

A G Ginovker

Publications and source records attributed to A G Ginovker.

At least 19 recordsLinked to original sources
PubMed1985

[Effect of an Opisthorchis infestation on implantation growth of the liver epithelium].

The features of proliferation and differentiation of the liver ductular epithelium from animals infected with opisthorchis were specified in experimental implantation growth. They manifested themselves in disorders of the mitotic regimen and intercellular interactions, in atypical proliferations and primary glandular metamorphism of regenerating cells.

Animals↗
PubMed1982

[Circadian rhythm of liver phospholipids in the normal golden hamster and in opisthorchiasis].

Circadian rhythms of total phospholipids, individual fractions of phosphatide acid, cardiolipin, phosphatidyl ethanolamine, phosphatidylcholine, sphingomyelin, and lysolecithins in the liver of golden hamsters infected with opisthorchiasis (days 30 and 150 of invasion) and freed from helminths (day 92 after dehelminthization) are desynchronized in phase, amplitude and level.

Animals↗
PubMed1980

[Chronobiologic studies of intestinal epithelium in the acute phase of opisthorchiasis].

Acute opisthorchiasis was simulated on 64 golden hamsters to reveal circadian rhythms of mitotic activity in the jejunum, ileum and cecum epithelium, with a maximum amounting to 3 hours. Acute opisthorchiasis modifies the mitotic regimen of the test parts of the intestine, smooths and distorts the rhythm. A conclusion is drawn about the reduced functional-structural reserves of gastrointestinal tract epithelium in helminthiasis in question.

Acute Disease↗
PubMed1979

[Circadian rhythm of changes in phospholipids and activity of non-specific phosphomonoesterases in rat liver].

The circadian rhythm of the content of total and individual phospholipids and the activity of alkaline and acid phosphatases was revealed in the liver of 130 white rats by the biochemical and histochemical methods. The concentration of phospholipids and enzymatic activity rise during the day time (9 a.m. - 15 p.m.). The results obtained suggest a good agreement between the structural and metabolic features of the liver during its maximal functional activity.

Acid Phosphatase↗
PubMed1975

[Mechanism of hypothalamic influences on bile formation].

Acute experiments were conducted on male rats; it was revealed that electrical stimulation of the nuclei of the anterior hypothalamus led to reduction of choleresis and to a fall of the potassium content in the bile, increase of permeability of the connective tissue stroma of the liver and of cell membranes of hepatocytes. Stimulation of the posterior hypothalamic nuclei induced an increase in choleresis, of the concentration of potassium ions and cholates in the liver, and also of the cholinesterase activity in the serum and homogenates of the liver. Permeability of connective tissue structures of the liver and of the intercellular spaces of hepatocytes proved to fall. The influences of the hypothalamus on bile formation included a change in the functional activity of hepatocytes and of the production of a fluid fraction of the bile.

Animals↗
PubMedDate not supplied

[The comparative characteristics of the clinico-immunological indices in different contingents of opisthorchiasis patients in a hyperendemic focus. 4. The transplacental transmission of Opisthorchis felineus antigens].

25 women in labour with chronic opisthorchiasis have been examined. They were representatives of native (7), local (8) and migrated population of the focus. Control group comprised 10 women from the local population free of invasion. Their immune status was assessed by the level of IgA, IgG, IgM, circulating immune complexes (CIC) and specific antibodies in the serum obtained from peripheral and funic veins, as determined by enzyme immunoassay (ELISA). To detect opisthorchis antigens in the serum modified radial immunodiffusion test was used. Antibody titres in ELISA, IgG and CIC levels were the highest in migrated women. Antibody titres in ELISA and IgG level in the newborn of migrated women were also considerably higher than in other newborn. Serum IgM level in all groups of newborn was considerably lower than in their mothers and IgA was altogether undetectable. In 3 native and 2 local women the results of immunodiffusion test were positive. It is suggested that transplacental migration of opisthorchis throughout the neonatal period may lead to tolerance formation.

Adult↗
PubMedDate not supplied

[The dynamics of the liver calcium-binding protein in golden hamsters with opisthorchiasis].

By means of immunochemical methods a considerable increase in Ca(2+)-transporting glycoprotein (GP) in liver tissues of golden hamsters at early stages of opisthorchiasis has been established. On the 3rd day after the infection GP amount increases 6 fold, on the 7th day--15 fold. On the 14th day GP amount decreases but does not reach the control level. The control level is reached only on the 22nd day after the infection of animals. Ca(2+)-transporting GP belongs to the system of electrogenic transport of Ca2+ in mitochondria (MCh) and its increase in MCh of the liver is, apparently, the basis of destructive changes of these organelles.

Animals↗
PubMedDate not supplied

[The decreased susceptibility of Syrian hamsters to Opisthorchis felineus invasion after its repeated administration].

The investigations conducted on Syrian hamsters have revealed that multiple enteral infusions of cold inactivated (t = -10 degrees C) O. felineus metacercariae resulted in the formation of immunocompetent cell and fibroblast infiltrations around the branches of the portal vein. The infestation of animals by viable pathogens led to reduced accommodation of helminths and suppressed cell infiltration in the liver. It is assumed that the native population of the foci become tolerant to the disease with the penetration of noninvasive Opisthorchis larvae into their body and the development of latent forms of helminthiasis.

Animals↗