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Biomedical subjects

A G Fraser

Publications and source records attributed to A G Fraser.

149 records · Page 9Linked to original sources
PubMedDate not supplied

Long-term follow-up of dilatation treatment of oesophageal strictures.

A review of the endoscopy records of 100 consecutive patients with oesophageal strictures was undertaken to determine the effectiveness of endoscopic dilatation therapy. The follow-up period from presentation ranged from 6 to 72 (mean 39 months) and the symptom-free period after the last dilatation ranged from 3 to 66 months (mean 29 months). Three hundred and fifty procedures were performed with no perforations and minimal morbidity. Eighty-one patients who had been followed for at least 12 months since their last dilatation were free of significant dysphagia. Of these 81 patients, 77% became symptom-free within 1 year, and 88% within 2 years. Only 35 patients required more than three dilatations; 30 patients required one dilatation and 35 required two to three dilatations. Age, sex, the presence of Barrett's oesophagus, or the oesophageal lumen diameter at presentation was not significantly correlated with outcome.

Adult↗
PubMedDate not supplied

The haggis tolerance test in Scots and Sassenachs.

To find out if the Scottish national dish, haggis, contributes to the high incidence of coronary heart disease in Scotland the lipaemic effect of a meal of 200 g of haggis was measured in six Scottish and 10 Sassenach men. The Scots had higher fasting cholesterol and triglyceride concentrations and a lower proportion of high density lipoprotein cholesterol than the Sassenachs. Four subjects were found to have hyperlipoproteinaemia, which had been unrecognised previously. Serum cholesterol concentrations did not change after haggis was eaten (mean dose 2.6 g/kg body weight). Serum concentrations of triglycerides increased by 51% at 90 minutes in the Sassenachs but were unaltered in the Scots. There were no serious adverse effects. This study shows that Scots have higher lipid concentrations than Sassenachs but seem to be resistant to the lipaemic effect of haggis. The haggis tolerance test may be useful in Sassenachs.

Adult↗
PubMedDate not supplied

Clinical assessment of prosthetic valve function.

The advent of high-quality ultrasound technology has made the assessment of prosthetic valve function quicker, easier, and more accurate than ever before. By using cross-sectional imaging, colour flow mapping, and spectral Doppler techniques from both the precordium and the oesophagus, it is possible to assess a prosthetic valve fully. Cardiac catheterization with its attendant risks can be avoided. Echocardiography gives detailed morphological information, and it can be used for routine serial follow-up of individual patients. Using the patient as his or her own control avoids the problems caused by poorly-defined 'normal ranges' for prosthetic function.

Angiocardiography↗
PubMedDate not supplied

Prevention of infective endocarditis: enthusiasm tempered by realism.

Infective endocarditis is a cause of substantial morbidity and mortality, and antibiotic prophylaxis may be appropriate in some circumstances. This article examines current British recommendations on prophylaxis, circumstances in which it may be beneficial and evidence for its efficacy.

Antibiotic Prophylaxis↗