Search PubMed⌕ Search

Biomedical subjects

A G Donald

Publications and source records attributed to A G Donald.

28 records · Page 2Linked to original sources
PubMed1979

An experiment in training in child care for general practitioners.

The educational objectives for training general practitioners are widely agreed. However, there is a shortage of paediatric posts in hospital, especially in Scotland. As there are obvious advantages in training clinicians who will work in general practice in the setting of general practice, we have initiated 10 posts in training each of six months' duration and each in addition to the trainee year. Three months will be spent in general practice itself and systematic teaching will also be provided for three months by the Edinburgh School of Community Paediatrics. Pre-course and post-course assessments will be carried out and the learning achieved will be evaluated.

Child Health Services↗
PubMed1976

Changes in the clinical picture of schizophrenia.

Records of all patients admitted to inpatient facilities of a state department of mental health from 1948 to 1952 and from 1965 to 1969 and diagnosed schizophrenic were reviewed to determine diagnostic trends, if any. The percentage of diagnoses of the catatonic subtype showed a general decline, the hebephrenic subtype showed a marked decline, the paranoid subtype a general increase, and the nonclassical subtypes a marked increase. Analysis of the symptoms for the subtypes and comparison between subtypes did not reveal any particular symptoms to be totally characteristic of a specific subtype. Many symptoms occurred with approximately equal frequency in all subtypes. Comparison of patients' symptoms for the two periods did not reveal wide qualitative variation between periods. However, there were large quantitative variations. We conclude that the apparent change in schizophrenia is but a moderation of primary symptoms.

Adolescent↗
PubMed1976

Tissue distribution of levo-methadone in nonpregnant and pregnant female and male mice: effect of SKF 525-A 1,2.

Male, nonpregnant and pregnant female (15-17 gestational days) mice were injected i.p. with saline or SKF 525-A (50 mg/kg) and 1 hour later with levo-3H-1-methadone (205 mug/kg; 0.8 and 5 mg/kg). Levels of free methadone were examined in some or all of the following tissues: brain, plasma, liver, lung, spleen, kidney, heart, eye, placenta, amniotic fluid, whole fetus, fetal brain and liver. In saline controls, the methadone concentrations in several adult tissues, whole fetuses, fetal brain and liver reached peak levels at 15 minutes and were negligible at 24 hours. Tissue levels of methadone increased in a dose-related manner; however, the brain/plasma concentration ratios with the three doses were almost unity at 15 minutes, 1 hour and 3 hours. Among adult tissues with high concentrations were the lung, liver, kidney and spleen; the brain in contrast contained very low concentrations. No notable differences were detected in the tissue levels of methadone in males and nonpregnant females; however, in pregnant mice significantly higher levels were observed in the lung and the liver. Fetal brain, liver and whole fetus concentrations were approximately similar. At 15 minutes, the fetal brain contained about 3 times more methadone than the maternal brain and the difference increased at subsequent times. Nonpregnant females excreted somewhat larger amounts of 3H in the urine than did pregnant females. SKF 525-A markedly enhanced and prolonged the concentrations of methadone in all the adult and the fetal tissues and lowered urinary excretion of total radioactivity in nonpregnant and pregnant females. Marked increases in tissue radioactivity after SKF 525-A might be due to a combination of effects involving inhibition of drug metabolism, altered tissue distribution and lower urinary excretion.

Animals↗