Search PubMed⌕ Search

Biomedical subjects

A G Cockburn

Publications and source records attributed to A G Cockburn.

9 recordsLinked to original sources
PubMed1985

Glutathione-S-transferase in human renal cell carcinoma.

Homogenates of human renal cell carcinomas were tested for glutathione-S-transferase, an enzyme of normal proximal tubule cells. All tumors were positive; mean tumor fraction enzyme activity was 0.040 +/- 0.02 mumol/min/microgram protein. Glutathione-S-transferase activity in homogenates from normal kidney was 0.022 and 0.054 mumol/min/microgram protein. Finding similar levels of a major cytosolic enzyme in tumor and renal cortex confirms the origin of renal cell carcinoma in the proximal nephron. Glutathione-S-transferase, which binds carcinogens and steroids, may play a role in carcinogenesis and serve as a marker for this tumor.

Carcinoma, Renal Cell↗
PubMed1984

Poorly differentiated (anaplastic) seminoma of the testis.

Anaplastic seminoma constitutes approximately 17% of total experience with seminoma at Memorial Sloan-Kettering Cancer Center. Among 25 previously untreated patients, 11 (44%) were clinical Stage I, and 14 (56%) were clinical Stage II or III. Treatment of these 25 patients with the same regimens employed for classical seminoma yielded an overall 80% 5-year apparent cure rate. Survival rates were poor in eight previously treated patients referred with recurrence.

Adult↗
PubMed1984

Hormonal therapy: the benefits of postponed initiation.

Although the efficacy of antiandrogen therapy is universally recognized in patients with prostatic adenocarcinoma, the dosage and timing of endocrine intervention remain controversial. Deferred anti-androgen therapy is advocated in asymptomatic patients with advanced prostatic cancer, primarily because of the palliative nature of this therapy and the attendant side effects of decreased libido, gynecomastia, or the cardiovascular morbidity associated with estrogen administration. Methodology may soon be available clinically for identification of patients with androgen-dependent tumors to maximize the effectiveness of treatment.

Adenocarcinoma↗
PubMed1983

Second primary germ cell tumors in patients with seminoma of the testis.

In a review of our experience with seminoma 9 cases of bilateral primary testis germ cell tumors were encountered, including 2 simultaneous and 7 successive. Of the 9 cases 6 were bilateral seminomas and 7 were stage I, contributing to the good survival experience. Treatment policy is specified and discussed.

Adult↗
PubMed1980

Crohn disease of penile and scrotal skin.

Genital cutaneous involvement with Crohn disease is an uncommon complication which has been described only recently. A case is presented of a young man with Crohn disease involving the penile and scrotal skin four years after total colectomy for Crohn disease. The histopathology and management are discussed. While the complications of Crohn disease vary in the literature, we believe involvement of the skin of the genitalia is uncommon.

Adult↗
PubMed1976

Radiolucent defects within renal pelvis.

Radiolucent filling defects within the renal pelvis are common findings in diagnositc urography, and because of their myriad causes the diagnostician is often faced with a challenging problem. Several of the more unusual causes of renal pelvis filling defects are described and their diagnosis, pathophysiology, and therapy discussed.

Adenocarcinoma↗