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A G Artemova

Publications and source records attributed to A G Artemova.

13 recordsLinked to original sources
PubMed1980

[Effect of anti-brain sera on the appearance of hypersensitivity of the delayed type and its adoptive transfer].

The effect of rabbit immunosera against CBA mouse brain on lymphoid cells of guinea pigs was studied in experiments with adoptive transfer of hypersensitivity of the delayed type. In vitro treatment of the transferred cells abolished their capacity for adoptive transfer. Such an effect of the sera was not selective with respect to the sensitizing antigen, i. e. it was nonspecific. Pretreatment with sera blocked the development of local allergic reactions of the delayed type and did not affect reactions of the immediate type.

Animals↗
PubMed1979

[Further study of the problem of specific cellular receptors in delayed hypersensitivity].

The work presents the materials obtained as a result of the further study of specific T lymphocyte receptors with the use of so-called receptor antisera, i. e. antisera against the lymphoid cells of mice sensitized with one of the two antigens (Macobacterium tuberculosis or bovine gamma globulin); thus these differed from control antisera against the lymphoid cells of intact mice. These mouse antisera reacted with the lymphoid cells of guinea pigs in experiments of delayed-type hypersensitivity transfer. The cells of sensitized guinea pigs lost their ability to transfer hypersensitivity if, prior to their injection into the recipient guinea pigs, these cells were treated with the above-mentioned mouse antisera, i. e. antisera against the lymphoid cells of mice had a blocking effect on the lymphoid cells of guinea pigs. The blocking action of the antisera proved to be specific: antisera against the lymphoid cells of mice sensitized to bovine gamma gloublin blocked the cells of guinea pigs, also sensitized to bovine gamma globulins, but did not block the cells sensitized to Mycobacterium tuberculosis. The control antisera, taken in the same doses as the factor antisera, did not show a blocking effect on the specific activity of lymphoid cells.

Animals↗
PubMed1979

[So-called antireceptor sera].

Experiments in delayed type hypersensitivity transfer were carried out with the aim of studying the ability of rabbit antisera against peritoneal exudate cells of rats sensitized with bovine gamma globulin or rabbit kidney tissue antigen to block peritoneal exudate cells of guinea pigs. In the serological test the antisera prepared against the cells of sensitized rats and tentatively named "receptor antisera", reacted not only with the cells of these rats, respectively, but also with guinea pig cells. In hypersensitivity transfer experiments in guinea pigs receptor antisera showed a blocking effect on the transferred cells, making them incapable of transferring hypersensitivity, i. e. rabbit antisera against rat peritoneal exudate cells reacted with guinea pig cells. This interaction was specific: the blocking effect was manifested only when guinea pigs whose cells were used in the transfer were sensitized with the same antigen as the rats against whose cells the receptor antisera had been prepared. The control antisera, taken for the treatment of the transferred cells in the same doses as the receptor antisera, had no blocking effect on the cells.

Animals↗
PubMed1975

[Study of specific cellular receptors in delayed type hypersensitivity].

The effect of immunosera (rabbit) against the lymphoid cells of mice sensitized with antigens causing development of hypersensitivity of delayed type (tuberculosis bacillus, tissue antigen from rabbit kidney) on the specific activity of lymphoid cells of guinea pigs was tested. The mentioned sera blocked the capacity of lymphoid cells of guinea pigs to transfer the state of sensitization from the sensitized donors to the intact recipients. Blocking was strictly specific and this capacity was absent in the immunosera against the normal lymphoid cells.

Animals↗
PubMedDate not supplied

[The migration activity of blood leukocytes as an index of the immunologic status of a kidney allograft recipient].

A total of 48 patients with chronic renal failure, 42 of them after allotransplantation of cadaveric kidney, were studied for leukocyte spontaneous migration and corresponding alterations in migration activity in the presence of renal antigens reflecting recipient sensitivity towards organospecific renal antigens. High levels of leukocyte spontaneous migrations and renal antigen sensitization were recorded in patients with acute course of renal transplant rejection versus those with no evidence of rejection or the persons with slowly progressing chronic rejection. It was stated that alterations in leukocyte migratory activity, both spontaneous and challenged by presence of renal antigen, could demonstrate the activity of immune processes in a recipient of renal transplant. The findings are of help in answering the question of how long the transplant could exist. Moreover, organospecific renal antigens are considered as possible participants, in line with transplantation antigens, in the mechanism of kidney rejection.

Adult↗