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Biomedical subjects

A Furusaki

Publications and source records attributed to A Furusaki.

28 records · Page 2Linked to original sources
PubMed1984

Oxetin, a new antimetabolite from an actinomycete. Fermentation, isolation, structure and biological activity.

A new amino acid-antimetabolite, oxetin, was isolated from a fermentation broth of a Streptomyces sp. OM-2317, a soil isolate. The chemical structure was elucidated as (2R,3S)-3-amino-2-oxetane carboxylic acid by analysis of the spectral data and by X-ray diffraction methods. The antibiotic is the first natural product possessing an oxetane ring. Certain microorganisms were inhibited by oxetin only when cultivated in minimal media. The inhibitory action was reversed by several amino acids such as L-isoleucine, L-methionine, L-valine and L-glutamine. It also exhibited herbicidal activity and inhibited glutamine synthetase from spinach leaves.

Anti-Bacterial Agents↗