Search PubMed⌕ Search

Biomedical subjects

A Funk

Publications and source records attributed to A Funk.

78 records · Page 5Linked to original sources
PubMedDate not supplied

[Intrauterine therapy of fetal supraventricular tachycardia with digoxin and verapamil].

Fetal supraventricular tachycardia may cause intrauterine heart failure and thus require transplacental treatment. During a period of nine years, we treated nine of eleven fetuses (gestational age ranging from the 26th to the 36th week) suffering from paroxysmal supraventricular tachycardia (10) or atrial flutter (1). The remaining two fetuses did not receive antiarrhythmic therapy because of only short lasting supraventricular tachycardia. Two fetuses were hydropic at the onset of therapy. Diagnosis of the rhythm disorder was established by m-mode echocardiography. All nine fetuses treated received digoxin after diagnosis of supraventricular tachycardia. Three of these reverted to sinus rhythm, one remained in supraventricular tachycardia which, however, was well tolerated. Five fetuses (three because of failure of digoxin alone and two because of a severely symptomatic supraventricular tachycardia) were treated with a combination of digoxin and verapamil. All five fetuses responded to the combined treatment, two of them, however, were delivered prematurely because of recurrence of supraventricular tachycardia in one and amnion-infection syndrome in the other. All patients survived and no severe fetal or maternal side effects were observed. Our experience confirms that digoxin and verapamil are usually effective in treating fetal supraventricular tachycardia. Some fetuses with short lasting and self limiting supraventricular tachycardia may not need any treatment, and a few not responding to digoxin and verapamil may require other antiarrhythmic drugs.

Cardiotocography↗
PubMedDate not supplied

[Uroflowmetry and ultrasound residual urine determination in pregnancy and post partum].

In order to estimate the influence of adaptational processes during pregnancy and post partum on micturition, uroflow-parameters (3) and residual urine were examined in 119 healthy women. Comparisons were made between women in the 1st, 2nd and 3rd trimester of pregnancy, women who were between 1 and 5 days post partum and nonpregnant, fertile women. Compared with the control group the mean flow was significantly lower during the 2. and 3. trimester. Time taken to achieve maximum flow was significantly higher after spontaneous delivery compared with the control group. During pregnancy and after delivery an increase in flow time could be shown. During the 3rd trimester time taken to achieve maximum flow was noticeably higher than in the other groups. Both mean and maximum flow were lower during pregnancy and after spontaneous delivery than in the control group. Residual urine increased mainly during the 1. trimester and showed the highest value after delivery. As all the investigated differences stayed within the standardized values, uroflowmetric investigations and ultrasonic residual urine estimation during pregnancy and after delivery are only necessary if suspicious symptoms on the part of the urinary tract exist.

Adult↗
PubMedDate not supplied

[Microbiologic cervix and amniotic fluid studies in early 2nd trimester: prognostic value for subsequent course of pregnancy?].

Our purpose was to determine the impact of cervical and amniotic fluid colonization in the early second trimester on the course of pregnancy. Cervical canal and amniotic fluid specimens were obtained from 167 patients without increased risk for prematurity. The specimens were examined for facultative-pathogenic bacteria (including mycoplasmas), fungi and Chlamydia trachomatis. The outcome of pregnancies was assessed in correlation with the microbiological findings. Of the patients studied 37% were cervically and 9% were intraamniotically colonized. Mycoplasmas dominated (cervix: 70%, amniotic fluid: 33%). In only two cases the same species was demonstrated at both sites. Women intra-amniotically colonized with microorganisms did not demonstrate a higher frequency of premature labor and premature rupture of membranes. Women with cervical detection of microorganisms demonstrate a tendency to higher frequencies of prematurity.

Amniocentesis↗
PubMedDate not supplied

[Neonatal, neurologic and psychosocial findings in higher order multiple births. Follow-up for 3 to 10 years].

We examined the outcome of 9 triplet, 3 quadruplet, 1 quintuplet and 1 sixtuplet pregnancies delivered between 1979-1989 at the perinatal center of the RWTH Aachen. The course of pregnancy and neonatal period were retrospectively analysed. The follow-up program covered at least 3, up to a maximum of 10 years. 12 families could be interviewed concerning psychosocial effects. The neonatal mortality was 4%. Neonatal morbidity; hyaline membrane disease (n = 18), intraventricular hemorrhage (n = 9), pneumothorax (n = 7), patent ductus arteriosus (n = 7), bronchopulmonary dysplasia (n = 8). At the age of 2 years 63% of the children were considered to be normal on developmental assessment, 17% showed mild, 20% severe developmental delay. With 3 to 10 years 83% were normal, 17% severely handicapped. In total 20% of the children died or showed severe handicap. Higher order multiple pregnancies make great demands on the perinatal medicine and lead in spite of an improved prognosis to a remaining burden for the children and their parents.

Brain Damage, Chronic↗
PubMedDate not supplied

[Sirenomelia--prenatal diagnosis and clinical consequences of a rare abnormality].

Sirenomelia or the mermaid syndrome is a rare birth defect, often combined with severe malformations of the urogenital system and the lower gastrointestinal tract. The incidence is about one case in 60,000. Ultrasound can be very important in early detection of this deformity. Because of the high incidence of oligohydramnios amnioninfusion could be helpful. Also a magnetic resonance radiographia in the prenatal period could be performed. We report three cases of sirenomelia and in addition the literature is reviewed and discussed.

Abnormalities, Multiple↗