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Biomedical subjects

A Fukui

Publications and source records attributed to A Fukui.

At least 163 records · Page 9Linked to original sources
PubMed1986

Experimental study of vascularized tibiofibula graft in inbred rats: a preliminary report.

An experimental study of vascularized tibiofibula grafts in inbred rats was performed. Roentgenologic and histologic changes of the grafted bone in the first seven postoperative weeks were especially investigated. After preliminary experiments on the vascular anatomy of the lower limbs of rats, tibiofibular vascularized grafts with femoral artery and vein were utilized in Fischer strain F-344 rats. The rate of bony union in the vascularized graft group was superior to that in the nonvascularized control groups. Fluorochrome-labeling studies of the grafted bone at the mid-diaphysis showed active periosteal new bone formation, following the vascularized graft. In contrast, normal tibial bone growth at the mid-diaphysis was mainly endosteal. However, both vascularized graft and normal bone demonstrated evidence of a "drift phenomenon" in the direction of growth. Since the life cycle of the rat is very short, compared with other laboratory animals, this experimental model may be useful in investigating the postoperative course of vascularized bone grafts with a short follow-up period.

Animals↗
PubMed1985

Light-illumination effects on the cellular concentration of photolyase molecules in yeast.

The effects of light-illumination in the absence or presence of cycloheximide (CHX) on the number of photoreactivating enzyme molecules per haploid cell of Saccharomyces cerevisiae (NPRE) were investigated. NPRE increased, when the cells were held in buffer in light in the absence of CHX for 24 or 48 h before UV-irradiation (buffer-holding). The increase of NPRE was clearly observed in cells, whose NPRE before bufferholding was small, that is, in stationary growth phase cells grown at 37 degrees C and in logarithmic growing cells incubated at 30 degrees C. In the case of buffer-holding in light in the presence of CHX or in the dark in the absence or presence of CHX, the increase of NPRE was small or not observed.

Buffers↗
PubMed1985

[Autotransfusion].

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Blood Transfusion, Autologous↗
PubMed1983

Thumb reconstruction with an iliac bone graft and a dorsalis pedis flap transplant including the extensor digitorum brevis muscle for restoring opposition: a case report.

A method for thumb reconstruction with an iliac bone graft and a dorsalis pedis flap transplant, including the extensor digitorum brevis muscle for restoring opposition, is presented. This case involved a 21-year-old man with a traumatically absent right thumb at the metacarpal base. Thumb reconstruction by means of an iliac bone graft with immediate transfer of a dorsalis pedis neurovascular sensory free flap, including the extensor digitorum brevis muscle to restore the opponens pollicis muscle, was carried out. After a period of six months he had gained satisfactory opposition of his newly reconstructed thumb to the ring finger, with evidence of contraction of the muscle on electromyograms.

Adult↗
PubMed1981

Light-flash analysis of the photoenzymic repair process in yeast cells. II. Determination of the rate constant for formation of photoreactivating enzymes-pyrimidine dimer complexes and its activation energy term.

As reported in the previous paper, the number of deoxyribodipyrimidine photolyase or photoreactivating enzyme (PRE) molecules per yeast cell was determined by the use of intense light flashes. In the present work, the reaction rate constant for the formation of PRE-substrate complexes, k1, and the activation energy term of k1 were determined by yeast cells in vivo by the use of light flashes. At 30 degrees C, k1 equalled (6.5 +/- 1.1) x 10(-5) (nuclear volume) x (molecule)(-1) sec(-1), which corresponded to 1.1 x 10(5) 1 mole(-1) sec(-1), on the assumption that a nuclear volume is 3 x 10(-15) 1. k1 showed positive temperature dependence as described by the arrhenius expression with an activation energy of 11.8 +/- 1.6 kcal mole(-1).

DNA Repair↗
PubMed1980

Microvascular anastomosis with absorbable and nonabsorbable sutures--a comparative study in rats.

Polyglycolic acid, polypropylene, and nylon sutures were used to anastomose the aortas of 40 rats. Comparative studies of the healing process at the suture sites were performed. The long-term observations, by means of light and scanning electron microscopy, revealed that the regeneration of endothelium was more rapid and the endothelium had a smoother surface in the aortas that received the polyglycolic acid sutures than in the aortas receiving polypropylene or nylon sutures because the polyglycolic acid sutures were absorbed after 6 weeks. It was concluded that polyglycolic acid suture material may be more desirable than nonabsorbable suture material in microvascular anastomoses.

Anastomosis, Surgical↗
PubMed1978

Microvascular anastomosis and its application on the replantation of amputated digits and hands.

Successful microvascular anastomosis depends upon the applications of magnifications, special instruments and fine suture materials, and the surgeon's skill in the technique. The key points of one millimeter vessel anastomosis are the wall-to-wall coaptation of the vessel ends, the fewer number of interrupted stitches with relatively loose knot. To gain good coaptation, an oblique insertion of a needle through the vessel wall must be used. In a thin-walled vein repair, the lumen should always be kept open with frequent irrigations. Between July 1965 and December 1976, 150 digits out of 168 in 111 cases and 11 hands in 11 patients were successfully replanted. All tissues must be repaired primarily. The repair of artery is performed first, recirculation is allowed with systemic heparinization, followed by vein anastomosis. The rehabilitation is commenced from the first day. To gain good function, several reconstructive surgeries may be necessary on the replanted digit or hand.

Adolescent↗
PubMed1977

Traumatic amputation of digits: the fate of remaining blood. An experimental and clinical study.

Experimental studies on rabbit ears amputated by either a clean sharp division or severed by a crushing blow showed that twice as much blood remained in the crush group. Microthrombi and tissue thrombi were seen in this group only. A review of 142 digital replantations performed over a 10 year period showed 126 survivals. Ninety-three were complete amputations and 80 of these survived; 49 were incomplete amputations and 46 survived after revascularization attemps. Of 74 clear amputations, 68 survived; of 68 crush-type amputations, 58 survived. Circulatory disturbances occurred in 36 replanted digits; 16 could not be salvaged. The primary cause of complications was venous obstruction. In 80 digital replantations done from January, 1974, to December, 1975, success was obtained in 75 (93.75 percent). Irrigation of vessels of the severed part is done only in cases of double level amputation, severely crushed or those due to avulsion. Heparin, low molecular weight dextran, urokinase, and antibiotics are given for several days after operation.

Amputation, Traumatic↗