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Biomedical subjects

A Frans

Publications and source records attributed to A Frans.

96 records · Page 6Linked to original sources
PubMedDate not supplied

Pulmonary diffusing capacity for carbon monoxide in simple coal workers' pneumoconiosis.

The lung diffusing capacity for carbon monoxide (DLCO single-breath) and its two components, the capillary blood volume (Vc) and the diffusing capacity of the membrane (DMCO) were measured at rest in 43 miners and 141 control subjects, the values in whom enabled reference formulae to be established; in 30 control subjects and in the majority of the miners these indices were measured during exercise. The main results are as follows: the diffusion indices are on average slightly decreased in simple coal workers' pneumoconiosis; both DMCO and Vc contribute to the lowering of DLCO, at rest and during exercise; individually Vc is more often significantly altered than DMCO; on effort the percentage increase of DLCO is normal in coal miners; the data during exercise suggest that smoking habit contributes more to lowering DLCO than does pneumoconiosis itself; lastly the diffusion indices are lower in miners with "pin-head" than those with micronodular opacities: this tendency is more pronounced during exercise. These findings are discussed.

Adult↗
PubMedDate not supplied

Blood gases in simple coal workers' pneumoconiosis.

Pulmonary gas exchange was measured at rest and during exercise in 30 normal males (14 smokers) and 43 coal workers free of obstructive syndrome, at three levels of oxygenation: hypoxia, normoxia and hyperoxia. The main results are the following: a) in normoxia PaO2 and (A--a)DO2 are slightly abnormal in coal workers at rest and during exercise; b) in hyperoxia (A--a)DO2 and venous admixture are higher in the miners at rest but not during exercise; c) in hypoxia (A--a)DO2 and DLO2 are abnormal in miners as compared with the control subjects; during exercise there is however no difference between the miners and the smokers of the control subjects; d) there is a correlation between PaO2 and (A--a)DO2 during exercise in normoxia and the various diffusion indices; e) (a--A)DCO2 and VD/VT show relatively slight increases in the miners; f) there are several differences between the miners with pin-head images and those with micronodular ones; g) at rest, (a--A)DCO2 and VD/VT are influenced by the degree of oxygenation. These various findings are discussed.

Carbon Dioxide↗
PubMedDate not supplied

Live influenza vaccine in patients with chronic bronchopulmonary diseases. A multicenter study with two consecutive vaccinal strains.

Live influenza vaccines RIT 4025 and RIT 4050, containing the recombinants of A/Scotland/840/74 and A/Victoria/3/75 with A/PR/8/34 virus respectively, were administered during the vaccination campaigns 1975-76 and 1976-77 to patients with established chronic bronchopulmonary diseases. The study was designed to assess the clinical acceptability of these vaccinal strains and to measure the effects of vaccination on pulmonary function in this population. Clinical and respiratory function findings were compared in a control group of healthy volunteers. Good immunogenicity and good clinical tolerance were found in both populations. Pulmonary function tests had been performed before administration of the vaccine and repeated several times during the post-vaccinal period; the longest post-vaccinal follow-up of respiratory function in patients was four weeks. Apart from transient fluctuations, no significant changes in pulmonary function were found; results obtained in the group of patients were not different from those o0served in healthy subjects. These results correlate very well with observations reported with previous vaccinal strains (Ann and Alice) in pulmonary "high risk" patients.

Bronchial Diseases↗