Biomedical subjects
Publications and source records attributed to A Franks.
An adult female is described in whom an area of lipoatrophy spontaneously appeared over the right side of the abdomen and chest. Idiopathic lipoatrophy affecting the trunk is rare and mainly described in Japanese children. We describe the condition occurring in an adult British female.
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The differential diagnosis of noninfectious desquamative inflammatory vaginitis includes pemphigus vulgaris, erosive lichen planus and benign mucous membrane pemphigoid. A 32-year-old woman had persistent, noninfectious, erosive vaginitis and linear deposits of IgA in the vaginal epithelial basement membrane zone. The differential diagnosis should be expanded to include mucosal involvement by linear IgA disease, a cutaneous vesiculobullous disorder.
The hypothesis that reversed blood flow in transiently occluded vertebral arteries may be responsible for some cases of massive traumatic subarachnoid haemorrhage has been investigated in vitro. Simple laboratory tests were performed on 25 vertebro-basilar arterial systems, and succeeded in producing either longitudinal tears in normally structured vertebral arteries, or tears at the origin of the posterior inferior cerebellar arteries. The results indicated that under such conditions, with systolic blood pressure in the physiological range, reversed blood flow had different characteristics and stressed the arterial wall to the point where it yielded.
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A seventy-six-year-old man from New Jersey developed multiple pustular lesions on his face, trunk, and extremities. These rapidly assumed a crusted appearance, and were proven, by culture and histopathology, to be North American blastomycosis. The patient was successfully treated with amphotericin B. Complement fixation studies paralleled clinical improvement and laboratory studies revealed impaired white cell function. It is postulated that the organism was first encountered fifty years earlier when the patient worked in an area in which blastomycosis was endemic.
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