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Biomedical subjects

A Franco

Publications and source records attributed to A Franco.

At least 379 records · Page 21Linked to original sources
PubMedDate not supplied

Primary non traumatic intracranial hemorrhage: 139 consecutive cases treated at an emergency regional hospital.

We review 139 consecutive cases of primary non-traumatic intracranial hemorrhage observed at the Neurosurgical Division of Pellegrini Hospitals, Naples. We excluded 20 similar cases which were not thoroughly studied. In the region Campania, which has almost five and a half million inhabitants, there are four emergency centres for neurosurgical patients one of which is at the Pellegrini Hospitals in Naples. In our series of 139 patients, 68 (48.92%) had an intracerebral hematoma (CH); while 71 (51.07%) patients had a subarachnoid hemorrhage (SAH). Thirteen cases out of 68 were added to the 71 cases with SAH because they had an arterial aneurysm or an arteriovenous malformation (AVM) which had ruptured both in the subarachnoid space and in the brain. The most frequent cause of CH was arterial hypertension. Out of 84 patients with SAH, 57 (67.85%) had a vascular malformation. Age, sex, presence of vasospasm, gravity of hemorrhage and interval between hemorrhage and neurosurgical observation were studied. Out of 139 cases, 68 (48.92%) were surgically treated. In conclusion, out of 68 operated patients, 48 (70.58%) survived and 20 died; while, out of 71 non-operated patients, 24 (23.80%) survived and 47 died. The survival rate of patients with aneurysms operated on after 14 days from the hemorrhage is 90.47%. The survival rate in patients with CH operated on after the fifth day is 89.47%.

Adolescent↗
PubMedDate not supplied

[The soleus syndrome. Apropos of 3 cases of intermittent claudication of venous origin].

UNLABELLED: The typical case present with a unilateral, atypical claudication with discrete oedema, occurring after repeated exercise. These paradoxical features of venous pain, aggravation with attacks, resolution after prolonged rest and the absence of arterial signs are suggestive of the disease. The syndrome may present as repeated calf thromboses or recurrent varicose veins suggesting some deep obstruction. An inflammatory and oedematous process linked to exercise is associated with a congenital predisposition: a constriction of the venous arcade at the insertion of the soleus. Phlebography confirms the absence of thrombophlebitis and shows underlying stasis and poor opacification of the deep popliteal and, most importantly, anterior hooking and actual kinking of the vein on the lateral film which persists on mild flexion. A simple surgical procedure to free the vein turns this incapacitating and potentially thrombogenic pathology into a benign condition. TITLE: Therapeutic modalities for ischaemic atrophy in its acutely painful phase or the exceptional use of corticotherapy in phlebology.

Adolescent↗
PubMedDate not supplied

[Occlusive rheoplethysmography in the diagnosis, surveillance and evaluation of the sequela of phlebitis].

Occlusive rheoplethysmography (RPO) constitutes a new method of quantitative tetrapolar rheography. It enables us to assess peripheral venous function by measuring distensibility (symbol of influx = IR greater than 0.6, and of drainage = IV greater than 0.7), and flow (symbol of the drainage flow = IDV greater than 0.5). Deep venous thrombosis in the receptor trunk of the popliteal vein and vena cava reduces the IDB (obstructive syndrome). Isolated thrombosis of the tibial vein modifies only the distensibility (restrictive syndrome). RPO is extremely reliable in the diagnosis of acute venous thrombosis of the receptor trunk, as well as in the diagnoses of tibial thromboses, and so it facilitates the recognition of indicants for phlebography. RPO constitutes a simple, portable, rapid, economical and totally objective examination; its use in the observation of the efficiency of treatments as well as in the quantitative assessment of phlebitic after-effects means that it makes a valuable contribution to the management of venous disorders.

Humans↗
PubMedDate not supplied

[Scientific communication in Spanish anesthesiology: medical congresses (1864-1936)].

This historical-medical study proposed to determine the evolution of knowledge in Spanish anesthesiology by examining conferences and presentations at medical congresses on record for the period between the first Spanish medical congress (1864) and the start of the Spanish Civil War (1936). We have found reports of 34 scientific meetings held during this period. All but two included news on anesthesiology or related matters. Ten were international meetings, while 25 were nation-wide conferences. We have been able to arrive at a good understanding of Spanish anesthesiology's evolution as a scientific discipline during this period.

Anesthesiology↗
PubMedDate not supplied

[Importance of the daily and political newspapers in Madrid on the introduction, popularization and awareness of anesthesia].

The introduction of surgical anesthesia in Spain and its spread throughout the country between 1847 and 1848 was facilitated by several medical journals and new daily and political newspapers in existence at the time, particularly in Madrid. This study was undertaken to determine the possible impact of articles reporting the discovery of anesthesia that were published in the contemporary daily press. Research involved a review of the daily press in Madrid, where most newspapers were published. We found 141 references to events surrounding the introduction of anesthesia in Spain in 24 Madrid newspapers. Analysis of the articles revealed how the daily press contributed to the rapid dissemination of information about the discovery. The press provided an important means of spreading news about and popularizing anesthesia and was also an instrument for exchanging scientific opinion for Spanish surgeons of the day.

Anesthesia, Inhalation↗
PubMedDate not supplied

[Severe accidental hypothermia: rewarming by total cardiopulmonary bypass].

We present a case of a 20-year-old male with a history of habitual drug use who suffered extreme hypothermia (26 degrees C) after several hours' accidental exposure to low ambient temperature. The patient presented in deep coma with recurring ventricular fibrillation that yielded to electrical defibrillation once a central temperature of 27.4 degrees C was reached through internal rewarming with intravenous liquids and gastric lavage with warm water. Because this method was slow, we decided to continue rewarming with extracorporeal circulation through cannulation of the femoral vein and artery. The patient recovered consciousness after three hours, with no neurological secuelae. Emergency room staff have available the means for recognizing hypothermia and a protocol for its management. Extracorporeal circulation is an effective method for internal rewarming and must be used when the patient requires cardiopulmonary resuscitation or presents signs of severe hemodynamic instability.

Adult↗
PubMedDate not supplied

Human hepatoma cells expressing HLA class I molecules stimulate primary responses of purified CD8+ T lymphocytes.

In the present study, we investigated the ability of major histocompatibility complex (MHC) class-I+ human hepatoma cell lines to induce primary proliferative responses of purified allogeneic CD8+ T lymphocytes. We found that HA22T/VGH and Li7A, but not HepG2 cells induced significant proliferation of CD8+ T cells and that these responses were dependent on class I molecule expression. In blocking experiments carried out to identify the costimulatory signals involved, we found that anti-ICAM1 monoclonal antibodies drastically inhibited CD8+ T-cell proliferative responses. These findings suggest that transformed hepatocytes expressing HLA class I molecules may participate in anti-tumour immunosurveillance by the direct induction of cytotoxic T-cell responses through ICAM1-mediated adhesive interaction.

Antibodies, Monoclonal↗