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Biomedical subjects

A Franco

Publications and source records attributed to A Franco.

At least 217 records · Page 12Linked to original sources
PubMed1992

[Thrombosis, immunology and drugs].

Diagnosis of thrombopenia due to heparin in sometimes false. We present a case with venous thrombosis in whom the suspicion of thrombopenia induced by heparin finally proved to be a quinidine induced lupus. Related to this observation we emphasise the importance of immunological investigation in patient with venous thrombosis.

Diagnosis, Differential↗
PubMed1992

Histomorphometric analysis of the rumen of sheep during development.

Histomorphometric and scanning electron microscopic analyses were carried out on 74 embryos and fetuses and 20 sheep (early postnatal to adult age). Histodifferentiation of the rumen took place at 33 days of fetal life. Ruminal pillars were observed at 42 days, and at 61 days, ruminal papillae appeared as evaginations of the epithelial stratum basale. Neutral mucopolysaccharides first appeared in epithelial cells at 46 days of fetal life; thereafter, numbers decreased gradually and subsequently stabilized in postnatal life. Acid mucopolysaccharides, mucins, and mucoid compounds were not detected. Age and diet were recognized as factors that determine the structure of the ruminal mucosa. Growth curves and formulas were set out for each tissue layer.

Animals↗
PubMed1992

[Predisposing factors for the development of acute severe tubular necrosis in the immediate post-transplantation period].

Retrospective study on the incidence of severe acute tubular necrosis (ATN), defined as the need for dialysis on the first week post-transplantation ruling out acute rejection or technical complication, in our series of 81 renal transplantations from corpse donor. It includes an evaluation of the influence on severe ATN presentation of parameters such as recipient and donor's age, level of plasma creatinine prior to extraction, whether the corpse had hypotension, duration of both vascular anastomosis and procedure, type of removal (single or multiorgan) and cold ischaemia. We conclude that in our experience, cold ischaemia of the graft is the only determining factor among the cases studied for ATN presentation conditioning a reduced long-term survival of the graft (0.758 vs 0.971 at 18 months: p.05). Peripheral blood typing of corpse donor would allow us to shorten cold ischaemia duration, and thus achieve a low rate of severe ATN (13.6%).

Adolescent↗
PubMed1991

An assessment of the radiological module of NEONATE as an aid in interpreting chest X-ray findings by nonradiologists.

NEONATE is a prototype of an expert system for the Newborn Intensive Care Unit developed at the Primary Children's Medical Center in Salt Lake City, Utah. A pilot study was undertaken to see if the addition of radiological frames to the NEONATE software could aid attending Neonatologists to interpret chest X-ray films. A set of radiological frames was created from rules generated by a radiologist. The performance of these radiological frames was compared to the performance of other radiologists using the Kappa statistic to measure agreement. There is a good agreement between the computer's decisions and the radiologists' decisions. The radiological frames were also tested to see if they help physicians who are not trained in radiology. A system that compares the residents' interpretation and the computer's interpretation to a gold standard interpretation was developed. It shows that the computer helps the first and second year residents, but not the third year residents. This article suggests that NEONATE's interpretation of chest X-ray findings are close to the radiologists' interpretations. While NEONATE's radiological frames help novice physicians in reaching better chest X-ray interpretation, the current study suggests that they are not likely to help a Neonatologist.

Evaluation Studies as Topic↗
PubMed1991

Specific changes in peripheral blood lymphocyte phenotype from burn patients. Probable origin of the thermal injury-related lymphocytopenia.

T-lymphocyte subsets from 27 severely burned patients and 32 controls were analysed using monoclonal antibody immunofluorescent staining and flow cytometry. Compared to normal controls, burn patients showed a remarkable reduction in absolute number of CD3-lymphocytes in the 48 h following injury, which was accounted for by a decrease in both CD4 and CD8 subsets. Activated lymphocytes, as defined by expression of CD25, CD69 and CD71, were significantly increased in burned patients. Additionally, a moderate increase in lymphocytes bearing simultaneously CD4 and CD8 was observed in some burned patients. The expression of CD11c, CD49a and CD54, members of the integrin family of cell surface molecules, was shown to be increased on lymphocytes from thermally injured patients. We conclude that thermal injury produces a profound T-cell lymphopenia with features of extensive T-cell activation, and postulate that depletion of circulating T-cells could be related with the expression of surface adhesion molecules and cell redistribution from blood to the tissues.

Adolescent↗
PubMed1991

Open channel block by gadolinium ion of the stretch-inactivated ion channel in mdx myotubes.

Currents flowing through single stretch-inactivated ion channels were recorded from cell-attached patches on myotubes from mdx mice. Adding micromolar concentrations of gadolinium to patch electrodes containing normal saline produced rapid transitions in the single-channel current between the fully open and closed states. The kinetics of the current fluctuations followed the predictions of a simple model of open channel block in which the transitions in the current arise from the entry and exit of Gd from the channel pore: histograms of the open and closed times were well fit with single exponentials, the blocking rate depended linearly on the concentration of gadolinium in the patch electrode, and the unblocking rate was independent of the concentration of gadolinium. Hyperpolarizing the patch increased the rate of unblocking (approximately e-fold per 85 mV), suggesting the charged blocking particle can exit the channel into the cell under the influence of the applied membrane field. The rate of blocking was rapid and was independent of the patch potential, consistent with the rate of ion entry into the pore being determined by its rate of diffusion in solution. When channel open probability was reduced by applying suction to the electrode, the blocking kinetics were independent of the extent of inactivation, suggesting that mechanosensitive gating does not modify the structure of the channel pore.

Animals↗
PubMed1991

Enhanced production of interferon-gamma by T lymphocytes cloned from rejected kidney grafts.

Seventy-seven T cell clones were generated from cell blasts infiltrating rejected kidney allografts. All clones, either CD4 or CD8, displayed cytolytic activity evaluated by lectin-dependent cell-mediated cytotoxicity (LDCC) and natural killer activities. Furthermore, both types of clones were able to produce IFN-gamma following PHA stimulation. These data suggest that the graft infiltrate is characterized by T cell clones with cytolytic potential responsible for the killing of graft cells. The production of IFN-gamma, enhancing the class II MHC expression, may amplify the recipient immune response.

Antigens, Differentiation, T-Lymphocyte↗
PubMed1991

[Radiological and statistical determination of the morphological type of the canine skull: dolichocephaly, mesocephaly and brachycephaly].

Cranio-encephalic morphology of three breeds of dogs (Greyhound, Pointer and Pekinese at the rate of 10 subjects, 5 males and 5 females, in each one) has been radiologically observed. Radiographic negatives in dorso-ventral and latero-lateral positions were taken and analyzed before and after the visualisation of the encephalic cavity using barium sulfate. 18 cranio-encephalic measurements were chosen and interpreted statistically. The results showed that certain variables were more closely correlated with morphologic types of the cranium than others. We discuss the validity of the data applied for clinical diagnostic or osteo-archeology determinations.

Animals↗
PubMed1991

Computerized tomographic determination of the cranial volume of the dog applied to racial and sexual differentiation.

The volume of the cranial cavity of 70 dogs (35 males and 35 females) has been determined in two breeds, the galgo greyhound and the pointer, by radiological techniques (computerized tomography; CT) and biostatistical methods. Each head was submitted to a complete series of transverse tomographic sections taken perpendicularly to the basilar plane, every 5 mm and with a thickness of 5 mm. There is a clear difference between the breeds and the two sexes, with a minimal confidence of 99.95%. The application of the method to fit zootechnical and/or osteoarcheological needs is emphasized.

Animals↗