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Biomedical subjects

A Fournet

Publications and source records attributed to A Fournet.

45 records · Page 3Linked to original sources

[Evoked potentials in comatose children].

Auditory and somatosensory EPS obtained after median nerve stimulation are an interesting approach for the central nervous system investigation. However, there are some problems of interpretation during the first year of life, related to the maturation of the nervous system. We studied 20 severely comatose children aged 8 months to 15 years, admitted in an intensive care unit. Most of them were intubated, mechanically ventilated and received high doses of barbiturates. Coma was related to severe head injury, meningitis, encephalitis, Reye syndrome, malignant hyperthermia, cerebral lymphoma. Normal EP are correlated with a good recovery. Patients with abnormal EP may die or exhibit neurological sequelae. The absence of somatosensory EP is correlated with a bad outcome and is generally related to cerebral oedema. Appreciation of the prognosis in comatose children may be improved by repeated determination of auditory and somatosensory EP.

Adolescent↗

[Prolonged absence states in aged patients without epileptic antecedents].

Eight cases of [absence status] are reported, occurring in old patients (7 females, 1 male), mean age 75 years, without any known history of epilepsy. The main clinical feature was a fluctuating state of consciousness, during which the EEG showed diffuse spikes and polyspikes with a frontal predominance. These abnormalities disappeared after intravenous benzodiazepine administration, resulting in most cases in a spectacular clinical improvement. Five of our patients had a depressive history and were taking antidepressive or psychotropic drugs. Hyponatremia or hypokalemia probably secondary to diuretic medications, was present in 4 cases. No recurrence occurred with or without long-term anti-epileptic medication.

Aged↗

[Isolation and synthesis of espintanol, a new antiparasitic monoterpene].

The in vitro leishmanicidal and trypanocidal activities of a petroleum ether extract of Oxandra espintana have been investigated. Four aromatic monoterpenes were isolated, of which two are novel: espintanol [3a], responsible for the antiparasite activity, and O-methylespintanol [4]. Espintanol was tested in vitro on 20 strains of Trypanosoma cruzi and 12 strains of Leishmania spp. Its structure was determined by spectroscopic methods and confirmed by its preparation starting from carvacrol.

Animals↗