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Biomedical subjects

A Fogel

Publications and source records attributed to A Fogel.

At least 19 recordsLinked to original sources

All smiles are positive, but some smiles are more positive than others.

Disagreement as to whether all smiling or specific types of smiling index positive emotion early in life was addressed by examining when infants produced different types of smiling and other facial expressions. Thirteen infants were observed weekly from 1 to 6 months of age. Smiling alone--without cheek raising or mouth opening--was relatively more likely than periods without smiling both when mothers were smiling and when infants were gazing at their mothers' faces. Cheek-raise (Duchenne) smiling was relatively more likely than smiling alone only when mothers were smiling. Open-mouth (play) smiling was relatively more likely than smiling alone only when infants were gazing directly at mothers' faces. Smiling involving both cheek raising and mouth opening was relatively likely both when mothers were smiling and when infants were gazing at mothers' faces and became increasingly likely with age when both conditions co-occurred. The cheek-raise and open-mouth dimensions of smiling appear to be associated with, respectively, the amplification of processes of sharing positive affect and of visual engagement that are present to a lesser degree in smiling alone.

Affect↗

What's in a smile?

In positive social contexts, both adults and older infants show more Duchenne smiling (which involves high cheek raising) than non-Duchenne smiling (which does not). This study compared Duchenne and non-Duchenne smiles in early infancy for clues to their emotional significance. Infants (N = 13) from 1 to 6 months of age were videotaped weekly for 5 min in 208 face-to-face interactions with their mothers. Levels of Duchenne and non-Duchenne smiling were correlated within interactive sessions, and the 2 smiles had similar developmental trajectories. Duchenne smiles were typically preceded by non-Duchenne smiles. The results suggest these frequently contrasted types of smiles occur in similar situations and are often different temporal phases of a continuous emotional process. In contrast to adults, infant Duchenne smiles had longer durations than non-Duchenne smiles, suggesting infant smiling does not fit adult models of emotional functioning.

Affect↗

The integration of laughter and speech in vocal communication: a dynamic systems perspective.

Laughter in infant-directed speech was examined in 13 mother-infant pairs to investigate the possible co-occurrence of speech and laughter. Contrary to previous findings in adult-adult social interaction, all mothers produced speech simultaneously with laughter in up to 50% of laughs. In most of these speech-laughs the onset of laugh and speech was simultaneous. Laughter occurred on both function and content words and was more likely to occur on approximately 2 words and on utterances that were statements rather than questions or exclamations. Laughter and speech are different outcomes produced from a reorganization of the same vocal/anatomical parameters. A 3rd outcome is possible in the form of speech-laughs utilizing features from both laughter and speech. In speech-laughs, the duration of the vocalization was more likely to increase, and the changes in the utterance were likely to include 1 or more of the features of vowel elongation, syllabic pulsation, breathiness, and pitch change. These findings and individual variations in the resulting vocal output are discussed from a dynamic systems perspective. It is argued that neither speech nor laughter is dominant when both are combined, but that this is a more complex vocal outcome produced with idiosyncratic flexibility within stable temporal and physiological constraints.

Communication↗

Subclinical rubella reinfection during pregnancy followed by transmission of virus to the fetus.

We report a documented case of rubella reinfection during pregnancy in a previously vaccinated woman with residual antibody titre to rubella of 15 IU/ml. The reinfection occurred following an exposure to rubella virus (contact with 6-year-old daughter with clinical rubella) between the 7th and 10th week of pregnancy which resulted in transmission of the virus to the fetus. Umbilical cord blood drawn by cordocentesis was found to be strongly positive for rubella IgM antibody. After termination of the pregnancy rubella virus was isolated in cell culture from fetal tissues.

Adult↗

The relationship between smile type and play type during parent-infant play.

This study examined the relationship between smile type and play type during parent-infant interactions in the home. Thirty-six mother-infant and father-infant dyads were videotaped playing for 10 min. Smile type (basic, Duchenne, and duplay smiles) and play type (object, physical, vocal, and book reading) were coded. Results of loglinear analysis indicated that different types of smiles occur during different types of play more often than expected if distributed equally. In addition, different smile-type and play-type patterns occurred for father-infant dyads compared with mother-infant dyads. Qualitative analyses were used to generate hypotheses about the reasons why different types of smiles occurred during various play activities.

Adult↗

Rubella in pregnancy in Israel: 15 years of follow-up and remaining problems.

Despite extensive vaccination programs introduced in Israel since 1973, rubella virus continues to pose a threat to pregnant women. Screening for antibodies from women of childbearing age between 1980 and 1994 showed a decrease in seronegativity from 15.4% to 7% between the years 1980 and 1988, followed by an increase to 9.6% in 1991-92 due in part to the large wave of immigration from the former USSR, and a decrease back to 6.9% in 1993-94. The morbidity fluctuated, with peaks in 1983, 1987 and 1991, yielding a total of 219 cases in the target population of women of childbearing age. Additional problems encountered were reinfections, vaccine failures, and false positive results in screening. During the study period we confirmed 35 cases of reinfections in pregnancy, 19 of which resulted in delivery of healthy babies. In two of four cases of abortion following reinfection that we could follow, the fetus was infected. Immunization of 15-month-old babies introduced in 1989 and the new policy of two-dose vaccination introduced in 1995 are expected to further reduce the spread of rubella virus in the coming years.

Adult↗

Absence of an association between rubella vaccination and arthritis in underimmune postpartum women.

In a double-blind historical cohort study, 485 underimmune women who received rubella vaccine post-partum during 1985-1990 and 493 controls matched for age, place of residence and date of delivery were queried by phone concerning joint complaints following the pregnancy in question. Those reporting joint symptoms were invited for a personal interview at which joint symptoms and dates of their occurrence were explored in detail. Nineteen women in the vaccinated group (3.9%) and 16 from the control group (3.2%) were judged to have had joint symptoms compatible with the study definition of arthritis. The difference was not statistically significant. Thus, we were unable to find evidence for an association between rubella vaccination of underimmune adult women vaccinated post-partum and the subsequent development of arthritis. Rubella vaccine should continue to be used to immunize susceptible adult women against rubella in order to further the goal of elimination of the congenital rubella syndrome.

Adolescent↗

Vocal affect in three-year-olds: a quantitative acoustic analysis of child laughter.

Recordings were obtained of the laughter vocalizations of four 3-year-old children during three sessions of spontaneous free-play between mother and child in a laboratory playroom. Acoustic analysis was used to determine laughter durations, laughter events, F0, and harmonic characteristics, and to suggest a taxonomy of laughter types. Melodic contours were assessed from patterns of F0 change during laughter. Mean duration of laughs ranged from 200 ms to 2.0 s, but events within a laugh were usually about 200-ms duration. Laughs were intuitively classified into four major types, and, following the acoustic analyses, were further defined and classified into types and subtypes of exclamatory and dull comment; chuckle; basic, variable, and classical rhythmical; and squeal. Melodic contours included more rising contours than previously reported for cry, but there was great variability in the types of contours produced especially for rhythmical laughs. The results of the acoustic analyses are discussed in relation to (a) the development of a taxonomy of laughter and (b) different features of the vocal affect characteristics of high-intensity emotion.

Child Behavior↗

Lateral asymmetry in attention for three-month-old human infants during face-to-face interaction with mother.

A soft grip the size of an adult index finger was placed in the palm of 3-month-old human infants during face-to-face interaction with their mothers. In a between-subjects experiment, half the subjects interacted with mother for 3 min with no grip, which was followed by a 3 min interaction with the grip in the left hand; for the other half, the grip was placed in the right hand in the second condition. A within-subjects experiment compared the grip interaction for 3 min first in one hand and then in the other. The grip did not significantly alter the infant's gaze at mother, smiling, or positive vocalizations. The movements of the hand with the grip were suppressed similarly for left and right hands. Lateral asymmetry was found for looking to the left side when the grip was in the left hand, compared to no lateral preference in looking during any other condition. The results support a model of right-side dominance for attention control in infants.

Attention↗

Maternal speech to three-month-old infants in the United States and Japan.

An American-Japanese comparison of maternal speech to 3-month-old infants is presented. Mother-infant dyads were videotaped in the laboratory, and the maternal speech was analysed by function and syntactic form. US mothers were more information-oriented than were Japanese mothers; they also used more question forms, especially yes/no questions. Japanese mothers were affect-oriented, and they used more nonsense, onomatopoeic sounds, baby talk, and babies' names. The differences between countries in maternal speech addressed to 3-month-olds appear to reflect characteristic culture-specific communicative styles as well as beliefs and values related to childrearing.

Affect↗

Rubella-specific IgM in reinfection and risk to the fetus.

A case of reinfection with the wild rubella virus in the 8th gestational week is reported. The patient had preexisting hemagglutination inhibition antibodies of low titer following immunization with rubella vaccine. Reinfection was accompanied by clinical symptoms and the presence of rubella-specific immunoglobulin M (IgM) of high titer. Following termination of pregnancy no rubella virus could be isolated from the fetal tissues and the fetal blood contained no specific IgM antibodies. These results should encourage the use of cordocentesis before decision on interruption of pregnancy.

Abortion, Therapeutic↗

Isolation of HIV from Israeli patients and asymptomatic carriers.

Human immunodeficiency virus (HIV 1) strains were isolated from peripheral blood lymphocytes of eight homosexual men (two asymptomatic and six with lymphadenopathy syndrome) and of the wife of an AIDS patient with AIDS-related complex. All except one had antibodies to HIV in their serum. Virus isolation was carried out by cocultivation of the donors' peripheral lymphocytes with HUT-78 cells or with phytohemagglutinin-stimulated normal cord blood lymphocytes. Identification of the virus was based on detection of specific cytopathogenic effects, determination of reverse transcriptase activity, specific immunofluorescence and Southern blot analysis of HIV proviral DNA in the infected cell cultures.

AIDS-Related Complex↗

Detection of rubella-specific IgM antibodies by the staphylococcal absorption method (SAM).

The use of SAM for the detection of rubella-specific IgM was evaluated in the sera of 318 rubella convalescents, 79 vaccinees and 53 infants with congenital rubella syndrome (CRS). The method employed was based on the use of crude inactivated suspension of Staphylococcus aureus strain Cowan I in the hemagglutination inhibition (HI) test and 1-h incubation of antigen and antibody. Among convalescents, 99% were found positive when tested within 30 days, and 84.6% were positive within 90 days following onset of clinical symptoms. Infants with CRS were 50 to 55% positive at the age of 0 to 6 months and 23% at the age of 7 to 11 months. Overnight incubation of antigen and antibody increased the proportion of positive results, particularly among sera of rubella vaccinees. No false-positives were detected among 1,035 healthy controls; nor in 40 patients following cytomegalovirus or Epstein-Barr virus infection, nor in 22 sera containing rheumatoid factor (RF). Comparison of SAM with a commercial enzyme-linked immunosorbent assay (ELISA) kit based on antibody capture showed 84% correlation between the two methods. Discrepancies were observed mainly in low-IgM.antibody-containing sera.

Antibodies, Viral↗