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Biomedical subjects

A Flint

Publications and source records attributed to A Flint.

At least 109 records · Page 6Linked to original sources
PubMed1983

Primary aspergillosis of the larynx simulating carcinoma.

A case of pseudoepitheliomatous hyperplasia of the larynx secondary to fungal infection is presented. The laryngeal lesion resembled carcinoma both clinically and pathologically. Aspergillus species were identified in tissue sections and confirmed by immunofluorescence studies. The lesion responded well to antifungal therapy. This case is reported because of the extreme rarity of primary aspergillosis of the larynx, its occurrence in an otherwise healthy patient, and its marked resemblance both clinically and pathologically to laryngeal carcinoma.

Aspergillosis↗
PubMed1982

Human brucellosis caused by Brucella canis: clinical features and immune response.

Human infection by Brucella canis is not often recognized due to a lack of serious consideration of the disease as a diagnostic possibility. Another factor is the limited availability of specific serologic tests needed in the absence of cross-reactivity between antibodies to B. canis and other Brucella pathogenic to humans. In addition, the organism may not be isolated from blood culture, particularly after antibiotic therapy. We report clinical and laboratory features of four patients with serologically diagnosed B. canis infection and point out the importance of specific serologic testing for B. canis when brucellosis is a diagnostic possibility.

Adult↗
PubMed1982

The interstitial lung diseases: a pathologist's view.

The accurate diagnosis of the interstitial lung diseases requires that the pathologic features, whether they be derived from routine light microscopy, bronchoalveolar lavage material, ultrastructural or immunologic studies, be interpreted in the light of the clinical, roentgenographic, and physiologic presentations. The clinician must ensure that representative tissue is sampled and that the pertinent clinical data are supplied to the pathologist. Furthermore, the clinician should gain some appreciation of the pathologic changes commonly encountered. Such knowledge facilitates clinicopathologic correlations. The pathologist must ensure that the sampled tissue is handled in the most appropriate and efficient manner in order to realize the greatest diagnostic yield. In addition, the pathologist must convey to the clinician his confidence in the diagnosis as to whether the observed pathologic changes are diagnostically specific or nonspecific, in light of the clinical data. The diagnosis of interstitial disease in the immunocompromised patient entails even more intensive efforts, which must be accomplished in a very limited period of time. Only the close cooperation between clinician and pathologist can ensure diagnostic success.

Biopsy↗
PubMed1981

Subcategories of histiocytic lymphoma: associations with survival and reproducibility of classification. The Southeastern Cancer Study Group experience.

Five pathologists reviewed histologic slides from 134 cases of histiocytic lymphoma and subclassified these cases using Lukes-Collins classification system. Of 98 morphologically subclassifiable cases, 85 were distributed among three categories, each presumed to represent a lymphoma of follicular center cell origin. The remaining 12 cases were classified among three additional categories. The cases within the three follicular center cell categories, considered collectively, had a significantly better survival than did the cases within the other three categories considered as a whole. The pathologists classified cases generally as being of a follicular center cell type with a high degree of reproducibility, but their individual classifications varied significantly with respect to more specific morphologic categories. Suboptimal quality of histologic sections was a significant factor contributing to problems in morphologic classification. Ancillary immunologic techniques may be required for definitive subclassification of large cell lymphomas.

Adolescent↗
PubMed1981

Predictive ability of Lukes-Collins classification for immunologic phenotypes of childhood non-Hodgkin lymphoma: an institutional series and literature review.

Tissues from 22 children with non-Hodgkin lymphoma (NHL) were studied pathologically and immunologically. Most children were noted to have marked (B- or T-cell) neoplasms and the Lukes-Collins classification was predictive of immunologic phenotype in cases where markers were present. Our series and a review of the literature demonstrates that most abdominal NHL are B-cell in origin and are often small noncleaved follicular center cell lymphoma (Burkitt type). Most mediastinal primary lesions are T-cell in origin and of convoluted cell morphology. A few neoplasms (often peripheral nodal) lack the characteristic surface immunoglobulin or erythrocyte rosetting properties of B- or T-cell lesions, respectively. Frequently marrow and central nervous system involvement are observed in T-cell lymphomas and are not in frequent in B cell neoplasms. Shared immunologic and clinical features between the B- or T-cell lymphomas and their leukemic counterparts support the concept that they often differ only in the stage of disease progression.

Adolescent↗
PubMed1981

Immunoblastic lymphoma: an immunologic study.

An immunologic study of a 59-year-old man with immunoblastic lymphoma is presented. Shortly after his hospital admission, an uncompensated hemolytic process developed, caused by cold agglutinins. These antibodies had anti-i specificity, were of low titer at cold temperature, but demonstrated a high thermal amplitude. An apparent paraprotein was found by further immunochemical analysis to be polyclonal. The majority of cells in the peripheral blood (over 2000/cu nm), lymph node, and bone marrow that contained cytoplasmic IgG or IgM were plasma cells, although a small number of cells resembled lymphoblasts. Their staining with anti-lambda and anti-kappa chain reagents confirmed the polyclonality of the immunoglobins. Some plasma cells displayed the concomitant presence of both IgM and IgG immunoglobulins. Free immunoglobin was also demonstrated intercellularly in the lymph node section. The patient's acute hemolysis was controlled by plasmapheresis and eventually by combination chemotherapy. After chemotherapy, the clinical improvement was rapid, immunoglobulin levels returned to normal, and the patient remains asymptomatic 40 months after completing six courses of combination chemotherapy. This report provides evidence for polyclonal proliferation of B-lymphocytes in immunoblastic lymphoma.

Agglutinins↗
PubMed1980

Composite lymphoma: report of a unique case.

Composite lymphoma with more than one well demarcated non-Hodgkin's or Hodgkin's lymphoma in the same organ or mass is rare. Only 22 such cases, each with two lymphomas, have been reported. We describe a unique case in which there were three non-Hodgkin's lymphomas, according to the Rappaport's nomenclature, in the spleen and abdominal lymph nodes.

Abdominal Neoplasms↗
PubMed1980

Bezoar of the esophagus.

An esophageal bezoar occurring in a young patient without esophageal abnormality is described. The history of severe progressive dysphagia following forceful vomiting and presence of a gastric ulcer suggest that the esophageal bezoar might have originated in the stomach.

Adult↗
PubMed1980

Pseudotumor of the orbit and retroperitoneal fibrosis. A form of multifocal fibrosclerosis.

A patient with advanced renal failure and bilateral exophthalmos was found to have urinary obstruction caused by retroperitoneal fibrosis, as well as bilateral orbital pseudotumors. Pseudotumor of the orbit, especially when bilateral, has been associated with a wide variety of systemic conditions. Although the association of pseudotumor and retroperitoneal fibrosis is uncommon, any patient with bilateral orbital pseudotumor and renal insufficiency should be examined for the possible presence of a treatable urinary obstruction.

Aged↗