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Biomedical subjects

A Fletcher

Publications and source records attributed to A Fletcher.

244 records · Page 14Linked to original sources
PubMedDate not supplied

Quality of life assessment in blindness prevention interventions.

This article discusses the importance of self-reported visual function and quality of life (QOL) assessment in evaluating the effectiveness of eye care and prevention of blindness interventions. Traditional clinical measurements do not provide an adequate characterization of the burden of visual disability faced by the patient in day-to-day activities. The validity, reliability and responsiveness of QOL questionnaires should be demonstrated before general use of such instruments is advocated. A visual function questionnaire currently undergoing psychometric evaluation as part of a clinical study of cataract surgery in India is presented.

Blindness↗
PubMedDate not supplied

Fibrinogen catabolism in patients with type II and type IV hyperlipidemia. Effect of dietary and clofibrate treatment on laboratory findings.

Fibrinogen catabolism was studied by plasma fibrinogen chromatography and other methods in 99 subjects with hyperlipoproteinemia Types IIa, IIb, and IV, and in 24 control subjects with normal blood lipid values. Subjects with either a history of thromboembolic vascular disease or clinical evidence of atherosclerosis were excluded. Type II subjects (i.e., the combined group of Type IIa and IIb subjects) showed an elevation of plasma high molecular weight fibrinogen complexes, which is indicative of enhanced fibrin formation. They also showed an elevation of fibrinogen-first-derivative, which is indicative of fibrinogenolysis and increased plasma euglobulin activity. Subjects with Type IV hyperlipoproteinemia showed similar findings to those of Type II except that high molecular weight fibrinogen complex concentration was normal. Subsequently, 36 patients received a fat-controlled, low cholesterol diet and were studied in a blind, random, crossover study of dietary vs clofibrate treatment. Although total cholesterol and triglyceride levels fell significantly during the treatment periods, chromatographic findings of abnormal plasma fibrinogen remained unchanged.

Adult↗
PubMedDate not supplied

Quality of life in the management of hypertension.

Results from long term trials suggest that first line treatment with the diuretic chlorthalidone is not associated with any adverse effects on quality of life including cognitive performance. Similar findings may be true for other diuretics but there is less evidence. However chlorthalidone and other diuretics do produce erectile problems in around 10% to 15% of middle aged men while the proportion of older men affected is not known. Beta blockers have mixed effects but recent drugs of this class have minor, if any adverse impacts. Calcium channel blockers, especially dihydropyridines, are associated with higher discontinuation rates. ACE inhibitors appear to cause minimal impairment to QoL; they do not interfere with cognitive function or sexual performance and are associated with a low withdrawal rate. Greater control of blood pressure is associated with improved quality of life as are strategies such as weight loss and increased physical exercise.

Adult↗
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A world of kindness.

Explore the source record for details and available documents.

Health Facility Environment↗
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Compression therapy for venous ulcers: a systematic review.

This article summarises the findings of a systematic review carried out by the NHS Centre for Reviews and Dissemination and the Center for Evidence-Based Nursing. Based on a rigorous analysis and synthesis of available research, the review concludes that training in the assessment of leg ulcers and the correct application of compression therapy appears to be more important than the particular products used. Recommendations for audit are also reported.

Bandages↗