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Biomedical subjects

A Fleming

Publications and source records attributed to A Fleming.

At least 73 records · Page 4Linked to original sources
PubMed1983

Tarsal tunnel syndrome and peripheral neuropathy in rheumatoid disease.

Thirty patients with classical or definite rheumatoid disease (RD) with foot pain and radiologically demonstrated erosions were studied electrodiagnostically to ascertain the frequency of the tarsal tunnel syndrome and peripheral neuropathy. Four patients (13.3%) had evidence of the tarsal tunnel syndrome. The electrical abnormalities were mild and unassociated with specific clinical features. Two patients (6.6%) had evidence of sensory peripheral neuropathy. There may be an appreciable frequency of clinically unsuspected tarsal tunnel syndrome in RD.

Adult↗
PubMed1983

Osteonecrosis of the humerus related to pregnancy.

A case of osteonecrosis of the head of the humerus is described in which the only likely precipitant was pregnancy. The association of pregnancy and osteonecrosis is reviewed. This is the first reported case of osteonecrosis of the humerus alone associated with pregnancy.

Female↗
PubMed1982

Nonaversive treatment of severe self-injurious behavior: multiple replications with DRO and DRI.

Sixteen severely self-injurious residents of a state mental retardation facility were treated with conventional, non-aversive behavior modification techniques by the same staff over a four-year period. Although each resident had performed multiple self-injuries prior to treatment, including blindness, multiple permanent scars, punctured eardrums, etc., 12 of the 16 improved in terms of decreased frequency of self-injurious behavior (SIB) and decreased frequency of measurable physical injury; of these, seven ceased SIB altogether. Each resident's treatment was unique, which necessitated unique analyses of controlling antecedents and maintaining consequences. Two exclusive types of self-injurious residents became evident: a) those whose SIB was maintained by socially reinforcing consequences and b) those whose SIB was maintained by escape contingencies. The study suggests that in agencies where intensely aversive techniques cannot be used to treat SIB, occasional restraint control of behavior can be combined with intensive differential reinforcement of other (DRO) or incompatible (DRI) behavior to produce an extended but satisfactory probability of successful treatment. Similar to published results from intensely aversive treatment, mildly aversive treatment, which largely depended upon positive reinforcement of desirable alternative behaviors, did not completely suppress the most severe SIB.

Adolescent↗
PubMed1981

Enteric-coated pelletized aspirin. Gastrointestinal blood loss and bioavailability.

Eleven patients suffering from arthritis received, in a randomized cross-over study, anti-inflammatory doses of two aspirin formulations: Enpryn, capsules containing enteric-coated pellets; Rhusal, an enteric-coated tablet. No significant difference was found between the two formulations with respect to gastrointestinal microbleeding, plasma salicylate levels and urinary recovery of salicylate. Bioavailability studies carried out on 10 healthy male volunteers demonstrated that absorption from the enteric-coated pellet capsules was sustained and complete.

Aspirin↗
PubMed1981

A comparison of techniques for the elimination of self-injurious behavior in a mildly retarded woman.

The self-injurious behavior of an institutionalized, highly social, highly verbal, midly retarded woman was successfully treated through the use of boxing glove restraints over a 30-week period after unsuccessful, less-intrusive means were attempted. Application of the restrain was conditioned to be an (S-delta), contrasted with an expanding Differential Reinforcement of Incompatible behavior (DRI) during periods of restraint removal. Absence of self-injury was maintained at 18 month follow-up by which time she had been discharged to a community placement.

Behavior Therapy↗
PubMed1981

Clinical significance of immune complexes in rheumatoid disease.

Circulating immune complexes were measured by the Clq binding assay in 49 cases of rheumatoid disease. Raised levels showed a positive correlation with activity of the arthritis, the number of involved joints and the erythrocyte sedimentation rate. No correlation was found with age, sex, duration of disease, rheumatoid nodules, presented of radiographic joint erosions or other haematological and serological parameters. In 12 patients the arthritis subsequently remitted and this remission in disease activity correlated with reduced levels of immune complexes.

Antigen-Antibody Complex↗
PubMed1979

Vomeronasal and olfactory system modulation of maternal behavior in the rat.

The onset of maternal responsiveness by virgin female rats to foster pups was observed after (i) complete vomeronasal nerve cuts, (ii) partial olfactory bulb cuts, or (iii) the combined procedures. Although both vomeronasal nerve cuts and olfactory bulb cuts resulted in a more rapid onset of maternal care, relative to control animals with sham operations, animals sustaining the loss of both sources of olfactory input exhibited the shortest response latency. These findings are discussed in terms of the probable distinct functions of the two olfactory systems in the control of maternal behavior in the rat.

Afferent Pathways↗
PubMed1979

The association of haemopoietic dysplasia (pre-leukaemia) and abnormal cell clone with connective tissue disease.

A 68-year-old man with haemotological features consistent with haemopoietic dysplasia (pre-leukaemia) and an abnormal cell clone in the marrow, 46, XY, -18, +t(13;18) (q11;123), developed acute connective tissue disease characterised by vasculitis, dermal changes, marked muscular weakness and serological features suggesting an auto-immune disturbance. Although four other cases of haemopoietic dysplasia ("pre-leukaemia") with unusual connective tissue disease had been reported since the recognition of haemopoietic dysplasia as a distinct entity, a definite association between these two disease states still awaits confirmation by further reports and investigations.

Aged↗
PubMed1977

Relationship of radiological change to clinical outcome in rheumatoid arthritis.

Ninety-four patients with rheumatoid arthritis, seen within the first year after onset, have been followed prospectively with annual radiographs for a mean 63-1 months. An erosive arthropathy occurred in 72. The severity of the erosive changes showed a significant correlation with eventual clinical outcome. It is possible to predict a favourable outcome in those patients whose erosive changes become static at an early stage in the disease.

Arthritis, Rheumatoid↗
PubMed1976

Extra-articular features in early rheumatoid disease.

One hundred and two patients who presented with rheumatoid disease within the first year of onset were studied prospectively every four months for a mean 4.5 years to assess the incidence of extra-articular features. The features that seemed to be common in the early stages included hand-muscle wasting, carpal tunnel syndrome, lymphadenopathy, non-specific ankle swelling, and rheumatoid nodules, and to a lesser extent hepatomegaly, being underweight, conjunctivitis, skin transparency, and a palpable thyroid gland. Those features which seldom occurred early included scleromalacia, temporal artery inolvement, salivary gland enlargement, distal-motor neuropathy, splenomegaly, digital vasculitis, and pulmonary and cardiac complications. Being underweight indicated a significantly more severe outcome.

Adult↗
PubMed1976

Prognostic value of early features in rheumatoid disease.

Extensive data on 102 patients who presented with rheumatoid disease within a year of onset were gathered by a prospective study to assess the prognostic value of early features. Outcome was evaluated at a mean 4-5 years from onset on the basis of functional grade, extent of joint disease, early morning stiffness, and grip strength. Twenty-six patients improved, 14 pursued a mild steady course, and 62 had a persistently severe or deteriorating condition. The features recorded at the first visit were correlated with outcome. Those indicating a poor prognosis were: older age at onset, being underweight, poor grip strength, many affected joints, involvement of wrist or metatarsophalangeal joints, poor functional status, fulfilment of many of the American Rheumatism Association criteria for rheumatoid disease, raised erythrocyte sedimentation rate, seropositivity on sheep cell agglutination or latex tests, low haemoglobin level, raised blood urea level, and early erosions on x-ray films.

Age Factors↗