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Biomedical subjects

A Flatmark

Publications and source records attributed to A Flatmark.

At least 163 records · Page 9Linked to original sources
PubMed1980

Effect of pre-transplant blood transfusions and haemodialysis on the survival of first kidney grafts from living related donors.

The influence of pre-transplant blood transfusions and haemodialysis has been analyzed in 191 consecutive living related first transplants. A significantly increased graft survival was seen among patients having received blood transfusions and transplanted with a 1 haplotype disparate kidney, while no effect could be observed in HLA-identical transplantations. No significant effect could be detected on recipient survival. Four patients to receive 1 haplotype mis-matched grafts were sensitized against their potential donors by transfusions, and therefore not transplanted with living related donors. The frequency of first rejection episodes was highly significantly reduced in transfused compared to non-transfused 1 haplotype mis-matched transplanted patients while no influence was seen in identicals. Pretransplant haemodialysis improved graft survival, the difference was, however, only significant in the 1 haplotype mis-matched group. When analyzed for patient survival, the difference between the pre-dialytic patients and those on haemodialysis was even more pronounced. When analyzed separately, both blood transfusions and haemodialysis had a beneficial effect on graft survival.

Adult↗
PubMed1980

Renal transplantation in polycystic renal disease--a joint Scandinavian report.

During the period 1965-1977, a total of 339 patients with polycystic renal disease received at least 1 renal transplant at one of 10 transplant centres in Scandinavia. Patient survival at one year was 67%. The one year graft survival of 319 cadaveric grafts was 40%. The average age of the patient was 56.7 years. Patients who were 60 years or older (93 patients) had a significantly poorer patient and graft survival at one year (50% and 29.5% respectively). Patients receiving kidneys with O incompatibilities did significantly better than other donor-recipient combinations. Previous blood transfusions were associated with better graft prognosis, though the difference was only significant for 2 years. The incidence of posttransplant urinary tract infection (present in 47% of all the patients) was twice as common in patients with a history of pretransplant urinary tract infection (seen in 41% of all the patients). There was no association between posttransplant septicaemia and either pre- or post-transplant urinary tract infection. Only 10.5% of the patients were nephrectomized at the time of transplantation, half of these had urinary tract infection. Twenty-four per cent of the patients were nephrectomized in the posttransplant period, half of these because of infection. There was no difference in the graft survival data of the patients with or without pretransplant urinary tract infection. These findings justify a restrictive practice with regard to pretransplant nephrectomy in patients with polycystic renal disease.

Blood Transfusion↗
PubMed1979

Influence of HLA-A, B, C, and D matching and pretransplant blood transfusions on kidney graft survival.

A significant influence of matching both for the HLA-A and B and the D/DR antigens on graft survival in patients transplanted with kidneys from living related or cadaveric donors is demonstrated. A generally reduced survival of cadaveric grafts during the last few years may at least in part be explained by the use of more three and four antigen-mismatched donors. The beneficial effect of pretransplant blood transfusions on graft survival in our material is almost nulled when uremic patients, dying while waiting for a transplant, are also considered. In addition, significantly more high-risk patients are included in the nontransfused patient group.

Blood Transfusion↗
PubMed1978

Significance of HLA-D/DR matching in renal transplantation.

A low mixed-lymphocyte-culture response, indicating matching for HLA-D, was associated with a relatively good chance of graft survival in 62 recipients of renal transplants from living relatives mismatched for one or two HLA A and/or B antigens. In 96 cadaveric transplants prospectively typed for HLA-DR antigens, compatibility for these antigens improved the prognosis, irrespective of matching for HLA A and B antigens. In cadaveric transplants, a positive B-cell cross-match test before transplantation tended to predict inferior graft survival.

ABO Blood-Group System↗
PubMed1978

Dialysis fistulas and cardiac failure.

A haemodialysis fistula may be a factor in the development of cardiac failure, and surgical reduction of fistula blood flow can improve the condition. We have investigated 6 patients with dialysis fistulas and closed the fistula in one of them, with marked improvement of cardiac failure. It is unlikely that a peripheral dialysis fistula can cause cardiac failure by itself, but it may be a contributing factor when the cardiac reserve is reduced due to other causes.

Adult↗
PubMed1978

Portography of normal and regenerating dog liver.

The angiographic appearance of the portal vein in the dog before and after major hepatic resection is described. An increased diameter and length of the lobar vein and their ramifications were found following resection. The appearance both in the portal and sinusoidal phase indicated a diffuse growth of the liver remnant. One week after resection a portal hypertension was recorded, which had usually receded after six weeks. Major hepatic resection seems to imply a higher risk for fatal toxic effects from the contrast medium.

Animals↗
PubMed1978

Hepatic venography of normal and regenerating dog liver.

Total and selective hepatic vein angiographies were performed preoperatively and 6 weeks after 70 per cent liver resection in 6 dogs. The alterations in the hepatic vein system, increased diameter and elongation of the remaining lobar veins and their major tributaries plus increased angle between the radicles, are consistent with the findings earlier described by angiography of the hepatic arterial and portal venous system after major hepatic resection in dogs.

Animals↗
PubMed1978

Peroperative endoscopic diagnosis of small intestinal bleeding.

Two patients with recurrent bleeding from vascular anomalies in the small intestine are described. In both patients intestinal angiography had shown either pathological vessels or extravasation of blood into the proximal part of jejunum, but during explorative laparotomy the source of bleeding had not been found. The diagnosis was made by performing peroperative endoscopy. After resection of the involved small bowel segment one patient with cavernous hemangioma has remained asymptomatic. In the other patient, who suffered from a combination of multiple arteriovenous malformations and a congenital platelet defect, limited surgical resection did not influence the need of blood transfusions. This investigational approach should become the method of choice in patients suspected of bleeding from the small intestine.

Aged↗