Early colectomy in severe ulcerative colitis.
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Adolescent↗
Biomedical subjects
A Flatmark
Publications and source records attributed to A Flatmark.
Renal autotransplantation.
In the period, 1973-1985, a total of 305 renal autotransplantations (often with extracorporeal repair) were performed in 274 patients for fibromuscular (56) or atherosclerotic (98) renovascular disease, nephrolithiasis (97), renal tumor (15), or ureteral injury (8). One-third of the patients had reduced renal function, and approximately half of the patients with renovascular lesions presented with severe or malignant hypertension. The postoperative mortality rate of 4% was related to age over 60 years and reduced renal function. Postoperatively, 3.6% of the autografted kidneys were lost due to vascular thrombosis (7) or other causes (4). Twenty-five percent (69) of the patients had a solitary kidney. Two patients died postoperatively with functioning autografts. Long-term renal function remained stable in 60 patients, and deteriorated in 7. We conclude that autotransplantation and extracorporeal repair provide safe and efficient treatment for selected difficult renal lesions.
Adolescent↗
Mental disorders in ulcerative colitis: suicide, divorce, psychosis, hospitalization for mental disease, alcoholism, and consumption of psychotropic drugs in 178 patients subjected to colectomy.
The population in the Nordic countries is relatively homogenous. In 178 Norwegian patients subjected to colectomy for ulcerative colitis the frequencies of suicide, divorce, psychosis, and hospitalization for mental disorders, and consumption of psychotropic drugs, did not differ significantly from corresponding frequencies in the general population.
Adult↗
Serum gastrin in patients with azotemia.
Gastric acid secretion was determined by a pentagastrin test and serum gastrin concentration was determined by radioimmunoassay before and eight times during the first three hours after a test meal in six male azotemic patients and in nine male controls. The mean basal gastric acid secretion was higher, but not significantly so, in the patients than in the controls. The stimulated gastric acid secretion was equal in the two groups. The mean serum gastric concentration was found to be higher in the patient group than in the controls both in the fasting state and after the test meal. The interpretation of the results and the possible relevance of the results in deciding what prophylactic gastro-duodenal operation patients with high ulcer risk should be subjected to prior to kidney transplantation, is discussed.
Fasting↗
Influence of HLA matching on kidney graft survival.
The influence of matching for the whole HLA haplotype as well as for the separate HLA antigens controlled by this region, was studied in a material of 98 living related and 178 cadaveric first transplants. Graft survival corresponded closely to the degree of HLA haplotype disparity between donor and recipient. Furthermore, graft survival was less in combinations being incompatible for the serologically defined HL-A and -B antigens as compared to compatible combinations. A weak MLC response between donor and recipient, even in the presence of HL-A and -B disparity, might signify prolonged graft survival.
Consanguinity↗
Changes in renin and blood pressure levels during renal transplantation.
Early in the transplant program we experienced difficulty in maintaining the blood pressure after bilateral nephrectomy of a proportion of recipients receiving kidneys from living donors. To our surprise this problem was much less marked in the less prepared recipients with cadaver donors. It seemed possible that this could be related to our practice of preceeding transplantation with bilateral nephrectomy in the same session when the donor was alive, but not after necrotransplantation. A typical blood pressure chart from an operation combining renal transplantation with bilateral nephrectomy is shown in fig. 1. Even where there is no blood loss the systolic and diastolic blood pressure falls with the central venous pressure so that perfusion of the donor kidney is at first poor. As soon as perfusion is established however, the blood pressure rises.
Adolescent↗
Effect of prophylactic gastric resection on upper gastrointestinal (GI) complications in uremic and transplanted patients.
Among 125 consecutive transplant recipients 10 (8%) demonstrated previous or present peptic ulcer and 9 underwent prophylactic gastric resection before transplantation. Two of these patients experienced upper GI complications in the posttransplant period and 1 died. Another 7 patients without previous dyspepsia had similar problem after transplantation and 4 died. Prophylactic gastric resection is recommended in potential recipients with pretransplant ulcer disease.
Gastrectomy↗
Preliminary results with passive enhancement in human kidney transplantation.
Passive enhancement was attempted with F (ab') 2-fragments in six patients receiving their first and in one patient the second one haplotype mis-matched kidney graft. Administration of enhancing antibody in the first graft patients seemed safe, the group was however too small to determine whether the enhanced patients did better than those conventionally treated. The only pre-sensitized patient who received his second transplant rejected it during the first week, possibly due to a deleterious effect of the F (ab') 2-fragments.
Adolescent↗
Surgical treatment of lymphoceles.
Ten patients with lymphoceles after kidney transplantation are reported. Seven were treated with intraperitoneal drainage of the lymphocele, performed through a midline incision laparotomy. The postoperative course was uneventful, symptoms disappeared within 1 week. We consider this as the treatment of choice when lymphoceles develop after renal transplantation.
Biopsy, Needle↗
Experimental renal preservation with glucose-free perfusate.
Dog kidneys were preserved for 48 hours by hypothermic perfusion with either a glucose-rich or a glucose-free albumin perfusate. After reimplantation and contralateral nephrectomy renal function was assessed by serum creatinine determinations. The kidneys showed normal function and no difference between the two groups was found. The results suggest that glucose is of minor importance as a metabolic substrate for dog kidney preservation.
Albumins↗