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Biomedical subjects

A Fine

Publications and source records attributed to A Fine.

At least 217 records · Page 12Linked to original sources
PubMed1977

Effects of oral calcium gluconate on gastric acid secretion and serum gastrin concentration in man.

A single oral dose of 4-46 mmol calcium gluconate at pH 5-6 was administered intragastrically to 15 male volunteers without gastrointestinal disease. There was a significant rise in acid output from 30-90 minutes after the calcium was given compared with the basal hourly collection. The serum gastrin level 30 minutes after calcium administration was significantly raised, but no correlation could be demonstrated between the acid and gastrin responses. Serum calcium levels were unchanged throughout. An equimolar dose of magnesium sulphate had no such effects. This study suggests that the intragastric administration of calcium results in independent release of gastric acid and gastrin from the gastric mucosa.

Administration, Oral↗
PubMed1977

Tetracyclines: double blind clinical study to evaluate the effectiveness in periodontal surgery.

Twenty consecutive hospital patients who were to have periodontal surgery were assigned to one of two groups in a double blind clinical study. Ten were placed on tetracycline 250 mg, 6 times per day for 5 days. The other ten were given an identical appearing placebo 6 times per day for 5 days. The capsules were placed in a brown envelope so that neither the patient nor the periodontist knew which medication was being administered. The patients were randomly assigned to one of the two groups and were evaluated subjectively and objectively on the 3rd day and the 7th day. Statistically there were no differences between the two groups. In both groups there was some inflammation on the 3rd day but on the 7th day, it had subsided. Tetracycline is not recommended for routine prophylactic use in periodontal surgery.

Clinical Trials as Topic↗
PubMed1977

Bone scan findings in hypervitaminosis D: case report.

Bone scans in three patients showed generalized symmetrical increased uptake of radiopharmaceutical by the skeleton and absent or faint kidney images. It is thought that these appearances may be attributable to excess vitamin D, but other possible contributing factors, including the presence of renal osteodystrophy, are discussed.

Adolescent↗
PubMed1977

Informed consent in California. Latent liability without 'negligence'.

Informed consent is a legal obligation due from a physician to his patient, an obligation which may not be met by the physician's skillful treatment of his patient. It may only be met by the treating physician obtaining from his patient knowing authorization for carrying out the intended medical procedure. The physician is required to disclose whatever would be material to his patient's decision, including the nature and purpose of the procedure, and the risks and alternatives. The disclosures should be made by the physician to his patient, and not through use of consent forms which are not particular to individual patients. To minimize any subsequent claim by the patient that there was a lack of adequate disclosures, the physician should record in the patient's chart the circumstances of the patient's consent, and should not rely on the patient's unreliable ability to recall those circumstances.

California↗
PubMed1976

The renal handling of insulin and thyroid hormones in normal man.

1. The renal extraction of insulin and thyroid hormones T3 and T4 was studied in man by right renal vein catheterization. 2. The mean renal extraction of insulin was 0-46, suggesting that the right renal vein should be utilized in comparable studies. 3. No renal extraction of thyroid hormones was detected.

Adult↗
PubMed1976

Pharmacokinetics of frusemide in chronic renal failure.

1 The pharmacokinetics of frusemide have been studied in thirteen patients with severe chronic renal failure by using 35 S-frusemide. 2 The abosrption of aqueous frusemide was 57 +/- 20 percent (SD) and the bioavailability of 500 mg tablets was 42 +/- 12 percent, this differnece not assuming significance. 3 The renal clearance of frusemide was negligible (1.45 +/- 1.7 ml/min).

Absorption↗
PubMed1975

Elevation of serum gamma-glutamyl transpeptidase in end-stage chronic renal failure.

The serum gamma-glutamyl transpeptidase (GGT) was measured on 32 randomly selected patients about to commence or already on chronic haemodialysis. Raised values were found in 12 patients (37%). None of these patients had received drugs known to affect hepatic microsomes and all had normal liver function tests. The possible significance of this surprising finding is discussed.

Adult↗
PubMed1975

Alteration of hepatic acetylation in uraemia.

The rate of acetylation of sulphadimidine was estimated in 25 normals and in two groups of patients on intermittent haemodialysis. Group A consisted of nine patients who were about to commence or had already been on dialysis for less than one year. Group B consisted of eight patients dialysed for one to six years. There was a highly significant increase in the incidence of fast acetylators in group A (p less than 0.001) compared with a normal population. There is an alteration of hepatic acetylation in chronic uraemia. This trend appears to be reversed by prolonged intermittent dialysis. Alteration of hepatic metabolism may indicate an important compensatory role for the liver in uraemia.

Acetylation↗
PubMed1972

Changes of blood pressure, renin, and angiotensin after bilateral nephrectomy in patients with chronic renal failure.

Circulating levels of renin, angiotensin I, and angiotensin II were increased in six patients with chronic renal failure and hypertension uncontrolled by dialysis and hypotensive drugs. Lower and often normal levels were found in 10 patients whose blood pressure was controlled by dialysis treatment. For a variety of reasons all patients were subjected to bilateral nephrectomy. The logarithm of the decrease in plasma concentrations of renin and angiotensin II was significantly related to the fall of blood pressure after operation. Plasma renin concentration correlated significantly with blood angiotensin I concentration and with plasma angiotensin II in samples taken before and after nephrectomy. Renin, angiotensin I, and angiotensin II were measurable in samples of blood taken 48 hours or more after the operation.

Adolescent↗