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Biomedical subjects

A Fidalgo

Publications and source records attributed to A Fidalgo.

6 recordsLinked to original sources
PubMed2005

Etanercept for psoriasis: two case reports.

Psoriasis is a chronic inflammatory skin disorder. Recent advances in the understanding of its immunological basis have led to its redefinition as being T-cell mediated. New biological agents have been developed as effective selective target therapies and promise to be an alternative to conventional systemic medications. Etanercept is a recombinant human protein recently approved for psoriatic arthritis treatment that has activity against tumor necrosis factor-alpha (TNF-alpha). It is composed of the human TNF receptor linked to the Fc portion of human IgG1. TNF-alpha seems to play a key role in the pathogenesis of psoriasis and psoriatic arthritis. Therefore, etanercept TNF antagonism is an effective approach for severe psoriasis. We describe two case reports of severe recalcitrant psoriasis, also with arthritis, that showed a remarkable improvement with etanercept, with no adverse events.

Adult↗
PubMed2005

Topical tacrolimus in Hailey-Hailey disease.

Hailey-Hailey disease, or familial benign chronic pemphigus, is a rare relapsing-remitting autosomal-dominant epidermal blistering disease. It preferentially affects females and is characterized by recurrent vesicles and erosions in the intertriginous areas. There are several topical corticosteroid therapeutic options, which are often limited in their use by their secondary effects and localization of the lesions. We report a case of a 60-year-old woman with Hailey-Hailey disease involving axillary, groin, cervical, antecubital, inframammary and abdominal folds. She was treated with 0.1% tacrolimus ointment, applied twice daily, with clinical improvement in 2 weeks and total remission in 4 weeks. She remains asymptomatic after a 10-month follow-up period.

Adjuvants, Immunologic↗
PubMed1978

[Primary acetabular protrusion (author's transl)].

A case of primary protrusion of the acetabulum in a ten year old girl, is presented. A review of the tiology, history, clinical signs and treatment is done. Authors comment the influence of genetic factor in the mother and the father, in the clinical picture of their patient.

Acetabulum↗