Proceedings: Congenital clonic tetanic-like seizures.
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Biomedical subjects
Publications and source records attributed to A Fiaschi.
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The nature and the origin of the small pre-potential wave which can be recorded immediately before the main muscle action potential on indirect stimulation was studied in the median nerve of 12 normal subjects. It is considered to be a sensory antidromic response recorded from the large afferent fibres which innervate the thumb because it was recorded in all 12 subjects, and the threshold was always below the motor threshold. An antidromic response was recorded with stimulating electrodes at the thumb and recording electrodes at the palm. Both antidromic and orthodromic responses were recorded with stimulating electrodes at the palm. The amplitude of the pre-potential was higher at the recording point closest to the sensory fibres for the thumb and progressively decreased with distance in the other points.
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Myxedema coma, an extreme expression of hypothyroidism, represents a medical emergency with high mortality. Hypothermia and cerebro-vascular accidents should be taken into account for correct differential diagnosis. The treatment of myxedema coma is based on prevention of the precipitating factors and on the administration of generous doses of L-thyroxine and/or triiodothyronine, associated with steroids and drugs for respiratory and cardio-vascular complications.
Autonomic function has been studied in 30 insulin-dependent diabetic children and adolescents, through five cardiovascular tests. A significant difference between the diabetic and the control subjects was found in heart rate variations after deep breathing and after standing. Fifty percent of our patients showed an altered response to one or more cardiovascular tests. Although clinical manifestations of autonomic dysfunction are not frequent in young insulin-dependent patients, early signs of functional alterations are detectable in a high percentage of them.
The results of a computerized analysis of 555 newly recognized idiopathic epilepsy patients (301 males and 254 females) are presented. All patients were under 30 years over the period 1980-1985. The possible prenatal and perinatal risk factors (RFs) for epilepsy were investigated. The data showed that 307 patients (55.5%) had possible RFs; 162 had one possible RF, 145 two or more. The association of two or more RFs had a high frequency in secondary generalized epilepsy (66.6%) and in partial epilepsy. A multifactorial etiology of epilepsy is suggested, hypothesizing a connection either between prenatal and perinatal RFs or between multiple perinatal RFs.
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