Biomedical subjects

A Fernández Guardiola

Publications and source records attributed to A Fernández Guardiola.

7 recordsLinked to original sources

PubMed2001

[Analysis of eye disease and adaptation of visual aids in low vision patients: review of 1,000 cases].

PURPOSE: To study the success of visual rehabilitation in a group of 1,000 patients with low vision. METHOD: Clinical data on visual rehabilitation was studied in 1,000 subsequent patients suffering from visual impairment. Study focused on ocular disease, improvement in visual acuity and successful use of visual aids. A statistical analysis of results is presented. RESULTS: 25 cases dropped out due to issues in primary diagnosis. Remaining 975 patients were assigned to 9 groups: age-related macular degeneration (339) diabetic retinopathy (264 cases), myopic maculopathy (195 cases), glaucoma (96 cases), congenital maculopathy (39 cases), retinal detachment (12 patients), retinitis pigmentosa (13 cases), macular pucker (6 patients) and a miscellaneous group of 11 cases. The overall success in the improvement in visual acuity was 98% except for a group of patients with retinitis pigmentosa where a rate of only 46% success (p<0.01) was observed. 76% of cases finally accepted visual rehabilitation aids. CONCLUSIONS: The usefulness of visual rehabilitation in low vision patients is confirmed, with the exception of retinitis pigmentosa cases, probably due to features of the disease itself. The design of visual aids should be improved in order to benefit a greater number of patients.

Adolescent↗

PubMed1998

Brain thyrotropin-releasing hormone content varies through amygdaloid kindling development according to afterdischarge frequency and propagation.

PURPOSE: Thyrotropin-releasing hormone (TRH), present in extra hypothalamic brain areas, has been proposed to have neuromodulatory functions and to be susceptible to change by electrical stimulation paradigms. We measured TRH concentrations of several brain areas during kindling development before its establishment and determined whether the changes detected in TRH levels were related to the behavioral stages of kindling, the number of stimulations required to reach these stages and, with the electrophysiological parameters characteristic of this paradigm (amygdaloid afterdischarge (AD) frequency, duration, and propagation). METHODS: Male Wistar rats were implanted stereotaxically with indwelling bipolar electrodes in the basolateral nucleus of the amygdala and with two stainless-steel electrodes epidurally in frontal cortex. Amygdaloid kindling was induced by daily electrical stimulation; AD frequency and duration were recorded and analyzed throughout the development of kindling. TRH was extracted from several regions and quantified by radioimmunoassay (RIA). RESULTS: Modifications in TRH concentrations were detected, depending on the region assayed, from stage II of kindling. A positive correlation was noted between the levels of TRH and the frequency and propagation of AD, but not with the number of stimulations. The rate of change in TRH concentration in relation to AD frequency or duration was highest in frontal cortex followed by hippocampus and amygdala. CONCLUSIONS: A graded response was noted in the increase in TRH concentration dependent on the increase of AD frequency and propagation. The rate of response correlated with the region's epileptogenic susceptibility.

Amygdala↗

PubMed1982