Biomedical subjects
Publications and source records attributed to A Fabiani.
Two children affected by cerebral hydatidosis are described. For preoperative diagnostic purposes computerised axial tomography appears currently to be the most suitable procedure. Complete surgical removal of the cyst, with methods preserving its integrity, seems to be the main factor for definitive recovery as the different outcomes in the two cases show.
5 hemangiopericytomas have been studied together with 678 tumors of the CNS including 579 meningiomas, 13 fibrosarcomas, 4 malignant meningiomas, 3 unclassified malignant tumors and 79 angioblastic meningiomas. The main clinical and histological features of this series are discussed in order to identify the more useful criteria for biological and microscopical characterization of the hemangiopericytoma. Beside a pure type of growth, the presence of histological intermediate variants and mixed cell proliferations have been observed. The possibility of transitional features and mixed tumors is then outlined.
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A group of 5 selected malignant meningiomas was studied in relation to the incidence and morphology of the mitoses. Beside a high mitotic rate many structural chromosomal abnormalities were observed. In agreement with other malignant onco-types previously studied, the authors suggest that atypical mitoses together with a tissue and cytological undifferentiation may be assumed to be an important prognostic criterium for meningiomas. The problem of malignancy in meningiomas has not been, so far, satisfactorily resolved, so that, in our opinion, the definition of even minimal details may be of some interest. For example, as it clearly appears from reviewing the literature on this sugject, no particular attention has been paid to the mitotic features. Referring to previous studies on the mitotic abnormalities in different malignant cerebral onco-types, the authors aimed to examine the various mitotic aspects in a limited group of tumors selected on the basis of clinical and histological malignancy.
A case of cerebral cryptococcosis associated with pulmonary and bone lesions is described. While discussing some general data of the literature, the authors outline the rarity of granulomatous CNS Cryptococcosis. From a clinical standpoint the similarity with tuberculous processes is emphasized. The methods of histopathologic diagnosis both intraoperatively and in permanent sections are discussed.
The microglial participation in the different granulomatous processes was studied by silver impregnation techniques and histoenzymological methods. In florid granulomatous areas two types of metallophilic cells were detected, corresponding to the common macrophages and perhaps to the ameboid modification of the microglia. Hydrolytic enzyme preparations showed a pattern of distribution and intensity similar to that of the impregnated cells. Only in the adjacent nervous parenchyma the different methods evidenced the presence of hyperplastic ramified microglia associated with reactive astrocytes.
A clinical and pathological description of five cases of granulomatous mycoses of the C.N.S. is reported. Four had an intracranial and one a spinal localization. In all patients the clinical pattern was of tumoral type, while the disease evolution was favourable only in one case. From a histipatholic point of view the preliminary diagnosis was of granulomatous process. The fungi organisms were identified only by means of combined stain methods. Beside the pathogenetic problems the Authors outline some histological methods useful for diagnostic purposes when a culture procedure for fungi is lacking.
A rare case of primary cerebral actinomycosis is presented. Pathologically the most important finding is represented by two types of lesions occurring in the same granulomatous mass without abscess formation. The possibility of an associated infection by actinomyces israelii and actinobacillus actinomycetemcomitans or lignieresi is discussed.
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