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Biomedical subjects

A Fabbri

Publications and source records attributed to A Fabbri.

At least 217 records · Page 12Linked to original sources
PubMed1985

[Sudden and fatal malfunction of a Björk-Shiley prosthesis in mitral position due to rupture of the ventricular bracket and disk embolization].

Mechanical complications of prosthetic valves are increasing. The following report describes a case of fracture of a Björk-Shiley mitral prosthetic strut with dislogment of the valve occluder into the thoracic aorta. At the reoperation a new prosthesis was implanted but the patient died of acute heart failure. The diagnosis of valve disfunction must be made non invasively, because the time required for cardiac catherization usually constitutes a lethal delay. The only hope for survival is prompt surgical treatment.

Adult↗
PubMed1985

[Cardiac failure due to isolated pulmonary sequestration. Description of a clinical case in the neonatal period].

Pulmonary Sequestration is a congenital anomaly rarely seen in the pediatric age. Clinical manifestations commonly appear with a respiratory symptomatology and less frequently with cardiac signs especially in the case of an associated congenital heart disease. In the presented case, isolated Pulmonary Sequestration manifested itself as a congestive heart failure, and a diastolic overloading of the left ventricle. After surgical removal of the Sequestration was demonstrated a normalization of both clinical and haemodynamic findings.

Bronchopulmonary Sequestration↗
PubMed1984

Salmon calcitonin inhibits human sperm motility in vitro.

We have evaluated by a stroboscopic technique the in vitro effect of salmon calcitonin and human calcitonin on the motility of human migrated spermatozoa. We report here that human calcitonin is uneffective while salmon calcitonin is a potent inhibitor of the sperm motility. This salmon calcitonin action is abolished by the preincubation of the peptide with an anti-salmon calcitonin antiserum, demonstrating the specificity of the effect. In addition, we provide evidence that the release of intracellular calcium represents a necessary step for the action of the peptide. In fact, the salmon calcitonin effect is prevented in a dose-dependent way by dantrolene sodium which inhibits the release of calcium from intracellular stores while the calcium channel blocker verapamil is unefficacious. These results suggest a potential role for calcitonin in regulating human sperm motility.

Adult↗
PubMed1984

[Use of vancomycin in the treatment of severe Staphylococcus aureus infection. Description of 3 cases].

In recent years, the diffusion of antibiotic multiresistant staphylococcus strains in hospitals (especially aureus and epidermis) has created serious drawbacks as regards the treatment of severe septic forms and the systemic spread of these bacteria. The results of endovenous vancomycin treatment in three cases of sepsis with secondary localisations (endocarditis, osteomyelitis, pneumonia) caused by gram positive staphylococcus aureus are examined. The pharmaceutical was found to be effective in all cases and free from significant side effects.

Adolescent↗
PubMed1984

In vitro interaction between calcitonin and calmodulin.

The effects of salmon calcitonin and human calcitonin on the fluorescence spectra of a fluorescent conjugate of calmodulin with dansyl-chloride and on the calmodulin mediated activation of phosphodiesterase have been studied. We showed that salmon calcitonin provoked calcium-dependent modifications of the spectra of dansyl-calmodulin and completely inhibited the calmodulin mediated activation of phosphodiesterase with a maximum effect at the dose of 5.8 X 10(-7)M and 10(-7) M respectively. No appreciable effect of human calcitonin was observed in either system. This interaction of salmon calcitonin with calmodulin is similar to the interaction of certain neuropeptides and antipsychotic drugs to calmodulin and may explain certain of the peptide's pharmacological effects.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1984

Naloxone fails to increase LH levels in clomiphene treated men.

The gonadotrophin response to the opiate antagonist naloxone administered per infusion has been investigated before and after 5 days of clomiphene treatment in 5 male subjects. Before clomiphene treatment, naloxone caused a significant increase in LH levels, however, after clomiphene, naloxone failed to induce the same effect. An important role for gonadal steroids on the opiatergic inhibitory tone of LH secretion in man is suggested.

Adult↗
PubMed1984

Lack of endogenous opioid inhibitory tone on LH secretion in early puberty.

Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 micrograms of LHRH, 0.2 mg/kg of naloxone and 0.9% saline in single bolus. The gonadotrophin response was evaluated. The administration of naloxone failed to elevate LH levels in any of the subjects studied, even in those who showed a clear gonadotrophin response to LHRH. Unlike the response noted in adults, endogenous opiates do not appear to exert a tonic inhibitory influence on LH secretion during early puberty.

Adolescent↗
PubMed1983

Interpretative reproducibility of two-dimensional echocardiographic images. Analysis of intraobserver, interobserver and beat to beat reproducibility of the mitral valve orifice.

The intraobserver, interobserver and beat to beat interpretative reproducibility of two-dimensional echocardiographic images of the mitral valve area has been studied retrospectively in a group of 37 patients affected by rheumatic mitral valve disease. Reproducibility has been expressed either in terms of mean absolute or percent error of duplicate measurements. A group of 11 normal subjects was used for comparison. In our normal group the intraobserver, interobserver and beat to beat reproducibility averaged 1.8 +/- 2.1%, 3.1 +/- 1.4%, 2.7 +/- 2.0% or 0.12 +/- 0.14 cm2, 0.21 +/- 0.10 cm2, 0.17 +/- 0.13 cm2, respectively. In our patient population the intraobserver, interobserver and beat to beat reproducibility averaged 2.7 +/- 2.7% 4.1 +/- 4.9%, 4.6 +/- 3.6% or 0.05 +/- 0.05 cm2, 0.08 +/- 0.10 cm2, 0.08 +/- 0.06 cm2. In both groups there was no statistical difference among intraobserver, interobserver and beat to beat reproducibility either in terms of percent or absolute value. The mean percent error did not significantly differ between normal or stenotic valves or, in this latter group, among valves of different sizes (less than or equal to 1.4 cm2; 1.5-2.4 cm2; greater than or equal to 2.5 cm2). The mean absolute error, on the contrary, statistically differed between the two groups or among valves of different sizes, being larger in normals or in valves greater than or equal to 1.5 cm2. Thus, the interpretative reproducibility for two-dimensional echocardiographic images of the mitral valve area is small and acceptable for most clinical purposes.(ABSTRACT TRUNCATED AT 250 WORDS)

Diagnosis, Differential↗