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Biomedical subjects

A F Tsyb

Publications and source records attributed to A F Tsyb.

At least 91 records · Page 5Linked to original sources
PubMed1987

[Use of local hyperthermia in treating cancer patients].

Basic research in thermobiology made it possible to substantiate the advisability of incorporation of local hyperthermia in schemes of radiotherapy of patients with tumors of different sites. Positive experience of thermoradiotherapy of 301 patients with laryngeal, head and neck, uterine and rectal tumors and osteogenic sarcoma using the Soviet equipment indicated the advisability of wider employment of local hyperthermia in various schemes of radio- and combined therapy.

Combined Modality Therapy↗
PubMed1986

[Ultrasound diagnosis of the involvement of retroperitoneal and abdominal lymph nodes in Hodgkin's disease].

Ultrasonography and lymphography have been carried out in 238 patients with Hodgkin's disease to define the stage, recurrences and evaluate the efficiency of treatment. In 35 cases the results have been verified by morphologic study of lymph nodes removed during laparotomies. The results of ultrasonic study demonstrate involvement of lymph nodes of the spleen hilum, liver and other abdominal nodes found in 14 out of 115 untreated patients. The involvement of the nodes below the diaphragm has been found in 39 patients out of 123, subjected to different treatments. The significance of the technique in evaluating treatment efficiency, diagnosing recurrences and progression of the process has been shown.

Abdomen↗
PubMed1986

[Lymphography, computed tomography and ultrasonic examination in determining the involvement of retroperitoneal and abdominal lymph nodes in Hodgkin's disease].

Altogether 45 patients with Hodgkin's disease were examined with the help of lymphography (LG), computerized tomography (CT) and ultrasonography (USG). The LG, CT and USG results obtained in 20 patients were compared with the histological findings. The retroperitoneal lymph nodes contrasted in LG, when involved in a pathological process, were detected with approximately the same accuracy in CT and USG. The abdominal lymph nodes undiscernible on lymphograms, were visualized in CT and USG, the sensitivity of USG was higher than that of CT. An optimum scheme for examination of patients with Hodgkin's disease with USG as the chief method was proposed. CT and LG are conducted depending on USG results and a clinical picture of disease.

Abdomen↗
PubMed1986

Impairment of left ventricular kinetics in lymphogranulomatosis with involvement of lymphatic mediastinal nodes.

Echocardiographic examination of 56 patients with lymphogranulomatosis involving lymphatic mediastinal nodes showed in four cases a paradoxical excursion of the interventricular septum and systolic thickening ("isosceles triange") of the posterior left ventricular wall. Clinico-instrumental examination of the patients made it possible to rule out in these subjects the presence of constrictive pericarditis, which had been formerly considered one of the causes of a disturbance of left ventricular kinetics.

Adolescent↗
PubMed1985

[Lymphography in cancer of the prostate].

The frequency and area of lymphogenic metastasis with relation to the histological structure, differentiation and degree of local dissemination of a primary tumor were determined at lymphography of 114 patients with prostatic cancer. Lymph node involvement was often observed in poorly differentiated and solid trabecular adenocarcinoma, scirrhous cancer and locally disseminated tumors extending beyond the prostatic capsule. Metastases were usually located in the external and common inguinal lymph nodes. Lymphography was shown to be indicated to patients with a local spread of prostatic cancer (T2, T3 and T4).

Adenocarcinoma↗
PubMed1985

[Ultrasonic scanning in determining the local spread of bladder cancer].

The results of ultrasound investigation were analysed in 48 patients with urinary bladder cancer. Potentialities of longitudinal intracavitary echography in the determination of the local dissemination of malignant urinary bladder tumors were studied. This method proved to be most informative for tumors sited in the cervix, basis and anterior wall of the bladder whereas transabdominal echography provided reliable diagnostic information for tumors of the lateral and posterior walls. In choosing methods for the determination of the local dissemination of urinary bladder cancer preference should be given to combined echography in view of its high accuracy, noninvasive and safe nature.

Adult↗
PubMed1985

[Ultrasonic diagnosis of splenic and hepatic lesions in lymphogranulomatosis].

Ultrasound investigation was conducted in 21 patients with Hodgkin's disease to determine the involvement of the spleen and liver in the process. The results obtained were verified histologically in 19 cases at laporotomy and in 2 cases at autopsy. Focal spleen lesion (focal sizes from 0.3-2 cm) was correctly recognized in 7 out of 9 patients, liver lesion in 3 out 4 patients. No false-positive results were obtained in cases in which spleen and liver lesions were not determined histologically. The value of ultrasound investigation for dynamic observation in liver lesion was emphasized. The method was recommended for a wide clinical use and assessment of therapeutic results of disseminated Hodgkin's disease.

Adolescent↗
PubMed1985

[Multicollector lymphography and phlebography in lower limb edema following radiation and combination therapy].

A multimodality x-ray study of the lymphatic and venous vessels was performed in 50 patients with secondary edema of the lower limbs. A complete block of the limb superficial lymphatic collectors was observed in 44% of the patients, a partial block in 26%. In 80% of the cases the level of partial or complete occlusion of the lymphatic vessels was noted in the ilioinguinal region and in 20% on the femur and leg. Distrubed permeability of the deep vessels of the femur and ilioinguinal region in the form of a complete or partial block was noted in 46% of the cases. In disturbed peripheral lymphodynamics different compensatory adaptation mechanisms like the functioning of the collateral tracts, lymphovenous anastomoses, the overflow of a radiographic contrast agent from the superficial vessels into the deep ones were observed in 60% of the patients. Indications for multicollector lymphography were defined. In secondary edema of the lower limbs, combined injuries of the lymphatic and venous systems were marked in 62%, an isolated disorder of the outflow of the peripheral lymph through the collector vessels was marked in 38%.

Combined Modality Therapy↗
PubMed1985

[Indications for lymphography in bladder cancer].

Proceeding from an analysis of the clinical and x-ray findings on 333 bladder cancer patients the frequency of lymphogenic metastatic spread was determined with relation to a degree of local extent of disease: T1 and T2--no metastases; T3a--metastases in 11.5%; T3b--in 30.3%; T4a--in 36.4%; T4b--in 50% of the cases. Metastases were mainly detected in the external inguinal lymph nodes. The lumbar lymph node involvement was always combined with tumorous changes in the pelvic lymphatic plexuses. Indications to lymphography with relation to a primary tumor spread (T3a, T3b and T4a) were defined. The authors determined the role of x-ray monitoring and repeated lymphography for the detection of metastases and a study of their regression caused by therapeutic measures.

Adult↗
PubMed1985

[Metastasis of cervical cancer (based on lymphography data)].

The frequency and extent of lymphogenic dissemination of cervical carcinoma versus histologic type, growth pattern and degree of local spread of tumor were studied on the basis of clinico-roentgenological data on 131 cases. Regional metastases developed in external and general iliac lymph nodes. Locally disseminated T1b, T2a and T3 tumors made the case for lymphography because it provided data necessary for radiation treatment planning. Roentgenologic follow-up and repeated lymphography were instrumental in evaluating the effectiveness of radiation treatment and detected lymphogenic metastases in 7.3% of cases.

Adenocarcinoma↗
PubMed1985

[NMR tomography of excised human lymph nodes].

The paper is concerned with the potentialities of the NMR-tomography technique (1H) for metastructure studying of the biopsied human lymph nodes both uninvolved and affected by tumor. Tomography was performed at 200 MHz using the Bruker CXP-200t mini-tomograph. Spin-echoes sequence and projection-reconstruction technique was employed. Spatial resolution was about 0.1 mm. Images of the uninvolved lymph nodes permitted one to detect the structure of the lymph nodes. NMR-imaging of unenlarged lymph nodes enabled one to localize the region of initial metastases. The reconstruction of various groups of spin-echo signals permitted a more precise detection of the regions differed in their spin-spin magnetic relaxation times T2 of protons in 1 mm slice. It may be assumed that the distinction in T2-relaxation rates of the normal and abnormal tissues displays an effective means to detect a pathological region using high-field tomography.

Adult↗
PubMed1983

[Use of electron acceptor compounds in radiotherapy].

Prerequisites for the use of electron acceptor compounds as radiosensitizers in tumor radiation therapy have been analysed. The short-term results of the treatment of 148 patients with metronidazole have been also analysed. A study of the distribution of metronidazole in the blood and tissues after its administration shows that the best route of its administration is a combined one (1/3 of the dose per os and 2/3 with the enema). In this case the highest level of the drug in a tumor was observed after 4-6 hrs. when radiation therapy was provided. A special scheme of radiation therapy with the use of metronidazole was worked out. The short-term therapeutic results with the use of metronidazole were somewhat better than those in the control group or did not differ from them.

Clinical Trials as Topic↗