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Biomedical subjects

A F Sabato

Publications and source records attributed to A F Sabato.

49 records · Page 3Linked to original sources
PubMed1981

[Identification of drugs in toxic doses in biological fluids using infrared Spectrophotometry].

A method permitting rapid analysis of biological samples from patients suspected of being intoxicated is reported. The method is based on: a) extraction of the active principles of biological samples with chloroform; b) drying and preparation of a disc of KBr; c) spectrophotometric analysis; d) integration of data from laboratory analyses with the clinical data from the patient. A number of clinical cases are also reported in which adoption of the method permitted rapid diagnosis of the possible aetiology of the toxic pictures observed.

Body Fluids↗
PubMed1980

Biochemical changes in neurosurgical patients under critical care treated with mannitol.

A Study was carried out on ten patients undergoing operations for brain tumors, who were treated with mannitol solutions. This caused a significant depletion of serum sodium ion and in an increase of discriminate osmolality (to 60 mosM/kg H2O). A hypothesis about the particular biochemical mechanism, involving the electrolyte and water distribution, is presented.

Acid-Base Equilibrium↗
PubMed1980

Lysine hydrochloride for the control of metabolic alkalosis: a clinical report.

Many physiopathological states can produce metabolic alkalosis that must be promptly corrected as soon as it is dangerous. In our study we report the effectiveness of lysine hydrochloride to correct this condition in patients. This drug lowers the pH, reduces the bicarbonate stores, and leads to normal blood gases.

Acid-Base Imbalance↗
PubMed1980

[Effects of CT 1341 (althesin) anesthesia on human adrenal cortical function].

Following a short introduction on the stress action of anaesthetics, the effects of anaesthesia with CT 1341 (Althesin) on cortico-adrenal function was investigated, with an evaluation of cortisone plasma concentration. The results obtained in 10 patients point to an increase in plasma cortisone after 30 and 150 minutes of anaesthesia. The discussion hypothesizes the possible influences of the anaesthetic on the hypophyseal-adrenal axis.

Adolescent↗
PubMedDate not supplied

Scrambler therapy.

UNLABELLED: In neuropathies there are complex reactions that modify the homeostatic equilibrium of pain system. In such a context the Scrambler Therapy (ST5) interferes with pain signal transmission, by ''mixing'' a ''non-pain'' information into the nerve fibres. The aim of this study is to evaluate the effectiveness of ST5 in the treatment of neuropathic pain. The ST5 consists of a multiprocessor apparatus able to simulate 5 artificial neurons by the application of surface electrodes on skin pain areas. A total of 226 patients, all suffering from intense drug-resistant neuropathic pain, were recruited for this trial in 2004. INCLUSION CRITERIA: neuropathic pain, very high baseline visual analogue scale (VAS). EXCLUSION CRITERIA: pacemaker users, neurolithic blocks or neurolesive pain control treatment. The treated neuropathic pain syndromes were: failed back surgery syndrome (FBSS), sciatic and lumbar painpost-herpetical (PHN), trigeminal neuralgia, post-surgery nerve lesion neuropathy, pudendal neuropathy, brachial plexus neuropathy, low back pain (LBP), others. The trial programme: 1 to 6 therapy sessions of 5 treatments, each one lasting 30 min. Pain intensity was evaluated using VAS before and after each treatment. The statistical significance of VAS was measured using the paired t-test. The total results show 80.09% of responders (pain relief>50%), 10.18% of partially responders (pain relief from 25% to 49%) and 9.73% of no responders (patients with pain relief<24% or VAS>3). The CONCLUSIONS: is draen that ST5 produced a statistically significant (P<0.0001) pain relief in all treated neuropathies.

Chronic Disease↗
PubMedDate not supplied

[Peridural anesthesia and adrenocortical function in man].

A brief account of the stress action of anaesthetic drugs is followed by the description of an evaluation of plasma cortisol concentration in an enquiry into the effects of peridural anaesthesia with bupivacaine.

Adrenal Cortex↗