Mechanical trauma of rat parotid gland led to an increase in the size of the gland (due to edema) with simultaneous activation of unspecific proteases, which were estimated at pH 7.6 using casein as a substrate. Administration of kallikrein-like salivary enzyme salivain into non-traumatized parotid gland caused also the same alterations. Complex application of two factors (trauma and salivain) resulted in distinct increase of the gland edema and the proteolytic activity. Administration of trasilol (inhibitor of proteases) decreased the pathogenic effects of salivain. After administration of salivain the alkaline phosphatase activity was shown to decrease in the parotid salivary gland.

Alkaline Phosphatase↗

PubMedDate not supplied

[Topography of hydrolytic enzymes in the oral mucosa of rats and dogs].

The activity of alkaline and acid phosphatases, RNases, DNase, BAEE-esterase, tissue proteases, peroxidase was determined in the oral cavity mucosa of rats and dogs. The essential topographical differences in the studied activity and its species peculiarities are found. The enzymic heterogeneity of the oral cavity mucosa may affect the frequency and the character of development of different pathological processes in it.

Acid Phosphatase↗

PubMedDate not supplied

[Effect of therapeutic enzyme preparations on submaxillary gland enzyme activity in rats with experimental traumatic submaxillitis].

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Animals↗

PubMedDate not supplied

[Effect of a number of enzyme preparations on the course of experimental parotitis].

Increase in the weight of rat parotid glands, decrease in the protein concentration and the activity of alpha-amylase with simultaneous activation of the proteolytic enzymes (caseinolytic activity at pH 7.6, activity of cathepsins at pH 5.5) were observed in pyo-traumatic parotiditis. Local administration of the protease inhibitor (contrical) or intramuscular treatment with trypsin showed the positive medical effect--decrease of the gland weight, increase in the protein concentration and in the alpha-amylase activity together with lowering in the activity of proteinases. Intramuscular administration of antimicrobic enzymes (lysozyme, RNase, DNAase) did not affect the pyo-traumatic parotiditis. Application of proteolytic enzymes or their inhibitors is recommended for clinical treatment of parotidites.

Animals↗