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Biomedical subjects

A Eyquem

Publications and source records attributed to A Eyquem.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[Assay of human anti-exoproteins to group A streptococci by microhaemagglutination: correlation with anti-streptolysin O and various anti-enzymes (author's transl)].

A microhaemagglutination test in disposable U plates has been devised for rapid, quantitative evaluation in antistreptococcal antibodies in human sera. Fresh or freeze-dried glutaraldehyde-treated sheep erythrocytes sensitized with over fifteen extracellular proteins released by group A Streptococcus pyogenes including streptolysin O, deoxyribonucleases, hyaluronatelyase, streptokinase and nicotinamide dinucleotide glycohydrolase were used. Haemagglutination and anti-streptolysin O (ASLO) titers were determined in parallel on 434 serum specimens from 123 healthy subjects ("controls") and 311 patients with a history of supposed or evident streptococcal infection. The titration of the four above-mentioned anti-enzyme antibodies has also been made on about 100 sera from both groups. Haemagglutination titre (HT) was less than 800 in control sera. By contrast it was greater than 800 up to 12 800 in patients specimens. Very good correlation was found between HT on the one hand and ASLO or anti-SK, anti-HA and anti-NADase antibodies on the other hand. HT and anti-DNase B antibodies were less correlated. Haemagglutination titres appear to rise earlier than serological titres of conventional streptococcal antibodies. The haemagglutination test described may be particularly helpful as a rapid serologic indicator of streptococcal infections and more reliable than the titration of ASLO alone, or of any one of anti-enzyme antibodies.

Antibodies, Bacterial↗
PubMedDate not supplied

[Diagnosis methods in Sjögren's syndrome (author's transl)].

The diagnosis value of various methods used to detect or confirm a Sjögren's syndrome are discussed. The Schirmer's test, generally abnormal, is a good test for detection, although not specific. A subnormal concentration of tears lysozyme is seen in about half of the patients, as so as the presence of anti-salivary ducts antibodies, or significant aspects in lip biopsy. The tests that are most frequently disturbed are the salivary immunoglobulin assay and the fonctionnal study of salivary glands with 99m technetium tracer but they are not specific. These abnormalities are neither constant, not specific: for this reason, there are frequently some problems in the diagnosis or the nosologic definition of Sjögren's syndrome. The occurrence in the same subject of many of these abnormalities makes however this diagnosis highly probable even in patients without functionnal troubles.

Autoantibodies↗
PubMedDate not supplied

[Clinical significance of circulating autoantibodies].

Indirect immunofluorescence on cryostat sections of rat, baboon and human organs is the best technique for routin detection of organ specific antibodies. Most of these antibodies (antinuclear, antinucleolar, anti-mitochondria, anti-parietal cells, anti-microsomes, anti-reticulin, anti-thyroglobulin, anti-salivary gland) are detected in less than 1% of normal adults ar a titer of 1/5. Their detection at high titers is of high clinical significance.

Animals↗