Expression of HLA class I-encoded cell surface antigens in transitional cell carcinoma of the urinary bladder.
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Carcinoma, Transitional Cell↗
Biomedical subjects
A Eyal
Publications and source records attributed to A Eyal.
Superior vena cava occlusion in a patient with antiphospholipid antibody syndrome.
A 55-year-old woman with a lupus like disease, associated with the lupus anticoagulant, was admitted because of facial edema. Her facial swelling was previously attributed to the steroids she had been taking and they were tapered without improvement. Laboratory tests revealed high titers of anticardiolipin antibodies. Computerized tomography of her chest and Doppler ultrasound examination of her neck veins demonstrated a thrombus in the superior vena cava. She was treated with heparin and was maintained with longterm warfarin therapy with uneventful followup. Superior vena cava obstruction should be added to the long list of thromboembolic complications of the antiphospholipid syndrome.
Antibodies↗
[Assessment of diabetic autonomic neuropathy by heart rate monitoring].
Assessment of diabetic autonomic neuropathy in a representative sample of 91 noninsulin-dependent diabetics was performed in 3 community clinics. A difference of less than 10 beats/min in heart rate between deep inspiration and deep expiration determined by ECG recording served as the criterion for autonomic neuropathy. By this test, 86% of the patients had diabetic autonomic neuropathy, a slightly higher proportion than that reported by others using similar criteria in more selected populations. The test is very sensitive and can be used for screening.
Adult↗
Asymptomatic or mildly symptomatic effort-induced myocardial ischemia: plasma beta-endorphin and effect of naloxone.
The hypothesis that endogenous opioids may be involved in reduced exercise-induced ischemic pain or in silent ischemia was tested. Fifteen male patients with coronary artery disease were tested in a randomized, double-blind crossover study. After a preliminary screening effort test they were divided into two groups: the first group of nine patients received an i.m. injection of naloxone 0.4 mg, or saline as placebo, and the second group, comprising six patients, received 4 mg naloxone or saline i.v. Effort testing was performed at weekly intervals on an ergometric bicycle, following the Bruce protocol. ECG, heart rate, blood pressure and pain perception were monitored continually. Blood was sampled through an indwelling venous catheter for beta-endorphin determination before, at the peak of, and 10-20 min following exercise. ST depression, heart rate, blood pressure and the double product were similar after naloxone and following saline administration. Beta-endorphin concentrations in plasma were significantly increased following exercise in the second group of patients. The increase in beta-endorphin concentration was larger when the patients were pretreated with naloxone (4 mg) than with placebo. However, chest pain was not significantly altered by either dose of naloxone.
Angina Pectoris↗
Variation of HLA-ABC surface antigen expression on adenocarcinoma of the colon in correlation with the degree of differentiation.
The expression of HLA class I antigens was tested on biopsy specimens originating from 90 patients suffering from adenocarcinoma of the colon. Three different samples were examined from each specimen: one from the tumor and the other two from the neighboring surrounding surgical margins. Twenty-seven out of 27 well-differentiated carcinomas were found highly positive for the presence of HLA class I antigens. Most of the moderately well differentiated tumors (37 out of 46) were weakly positive. None of the poorly differentiated tumors (n = 11) nor the mucin-producing tumors (n = 6) expressed HLA class I antigens. In 180 histologically normal colonic epithelia from patients suffering from adenocarcinoma of the colon (surgical edges free from tumorous tissue of the same specimens) no positive expressions were found. These results tend to suggest that class I HLA-ABC deficient, poorly differentiated tumors may possibly evade lethal immune aggression by HLA-restricted cytotoxic T cells and thus progress to overt malignancy. This negative expression may provide an explanation for the poorer prognosis observed among patients afflicted by a poorly differentiated adenocarcinoma or mucin-producing adenocarcinoma of the colon. Furthermore, these results tend to suggest that enhanced expression of HLA class I antigens on colonic epithelium could serve as a clinical laboratory indication for further examination looking for the possible emergence of neoplasm. If further verified, this may prove to serve as a predictive diagnostic tool for screening populations at risk.
Adenocarcinoma↗
Nephrotic syndrome associated with transitional cell carcinoma of the bladder.
We describe the occurrence of a nephrotic syndrome in association with transitional cell carcinoma of the bladder. The proteinuria disappeared several weeks after removal of the tumor. Light and electron microscopy were compatible with a minimal-change lesion, but immunofluorescence showed linear immunoglobulin deposition. Immunoglobulins eluted from the tumor reacted specifically with the kidney and vice versa. We conclude that antibody formation against a specific component of basement membrane common to both kidney and tumor gave rise to the nephropathy in this case.
Biopsy↗
Incomplete congenital sternal fissure.
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Adult↗
Mullerian adenosarcoma of the uterine cervix.
The management of cervical adenosarcoma in a 14-year-old girl is described. The tumor had an exceptionally violent biological nature and did not respond to a variety of customary and unorthodox therapeutic measures. These included conventional intravenous chemotherapy, radiation therapy, surgery, intraarterial chemotherapy, colostomy, and peritoneovenous shunt for untreatable ascites. The patient died within 16 months of diagnosis. This is the fifth case of cervical adenosarcoma in the English literature. This tumor usually has a better prognosis and none of the previous four cases succumbed to the disease. The unusual virulence of the present case is discussed and the literature reviewed.
Adolescent↗
Enterolithiasis.
We have seen two cases of enterolithiasis in middle-aged Bedouin women. In the first, the cause was prestenotic saccular dilatation from a postoperative stricture of the terminal ileum. In the second, stones formed in congenital diverticula in the terminal ileum and cecum. In both patients, the diagnosis was established by small-bowel enema.
Adult↗
Androgen therapy in hypogonadotrophic hypogonadism: time course of erotosexual functions.
This study was designed to assess the duration of androgen's effects on male sexuality to recommend an optimal therapeutic regime. Nine young men with hypogonadotrophic hypogonadism were repeatedly tested for 9 weeks after an i.m. dose of a Depo-testosterone preparation. Testing included self-rating of sexuality and recording of penile tumescence during sleep and during pornographic film, slides, and self-induced fantasy. Although serum testosterone decreased to subnormal levels by the fourth week, erectile strength, according to self-report, became subnormal by the eighth week, whereas other reported parameters remained unchanged. Erectile response to erotic stimulations remained unchanged for the entire 9 weeks. Nocturnal erections were supranormal for the first 2-4 weeks and normalized thereafter. Testosterone's effect on male sexuality seems to persist beyond the period of normal serum testosterone. Treatment can, therefore, be given bimonthly.
Adolescent↗
Acute acalculous cholecystitis--experimental and clinical observations.
Induction of acute acalculous cholecystitis was studied in dogs. Designed models included ligation of the cystic artery and/or duct separately or combined and injection of colonic flora into the gallbladder. Cholecystectomy was performed 72 h later. Histological studies of the gallbladders and bile cultures demonstrated various degrees of cholecystitis, the severest form occurring as a result of cystic artery ligation, whereas the mildest was produced by injection of bacteria. Secondary infection was a constant feature of our experimental models.
Acute Disease↗
Limited joint mobility and other rheumatological manifestations in diabetic patients.
Limited joint mobility was diagnosed in 42.9% of Type I and 37.3% of Type II diabetic patients. Abnormally thick skin was detected in 31.4% of Type I and 33.7% of Type II diabetic patients. Skin abnormalities were observed mainly in patients with L.J.M. There was a high prevalence of hand flexor tendon abnormalities (18.6%). Decreased range of shoulders and hips and flexor tendon abnormalities were significantly more common in patients with LJM. No significant association was found between LJM and grip strength, joint complaints, family history of rheumatic diseases, hypoglycemic attacks, cardiovascular diseases and autonomic neuropathy.
Adolescent↗
Burns caused by bromine and some of its compounds.
Our experience with infrequent and unfamiliar types of injury caused by various compounds of bromine are described and discussed. While bromine containing compounds share some of the characteristics of other common causes of chemical burns, they also have a specific, exclusive mode of affecting the skin. The delay in the appearance of clinical signs and symptoms is an important factor to be considered by those who treat injuries caused by bromine or some of its compounds, or by those who may be the first to see persons who are injured by these agents. As most of the injuries occur at work (92 per cent) it is in these industrial premises that considerable stress should be made of the importance of wearing protective clothing in order to reduce local damage and prevent systemic effects. Prompt first aid, by thorough washing with large volumes of water reduces the extent and depth of the injury.
Accidents, Occupational↗
Branched and polycystic thyroglossal duct anomaly.
An unusual thyroglossal duct anomaly characterized by a branched tract terminating in two separate cysts is described. The patient presented with a long-standing fistula following previous incomplete excision. Thyroglossal cysts are common congenital anomalies (Moussatos and Baffes, 1963; Allard, 1982), which do not usually present any diagnostic difficulty. However, they may sometimes present with unusual clinico-pathological features. In this report we describe a branching and polycystic thyroglossal duct abnormality occurring in a young woman with a history of previous surgery for a midline cervical mass.
Adult↗