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Biomedical subjects

A Ewert

Publications and source records attributed to A Ewert.

At least 55 records · Page 3Linked to original sources
PubMed1977

The combined effect of a cutaneo-lymphatic fungus, Sporothrix schenckii and a lymphatic-dwelling nematode, Brugia Malayi.

Domestic cats were infected with third-stage Brugia malayi in such a way that the parasites were restricted to the regional lymphatics of one hind limb. Later, these cats were exposed on the same leg to the yeast phase of Sporothrix schenckii. Edema and fibrosis were more extensive in cats infected with both Brugia and Sporothrix than in cats with either of these organisms alone. Lesions tended to appear earlier, more consistently and progressed more rapidly in cats with dual infections than in Sporothrix controls. No septic lesions were seen in any Brugia controls. Dissemination of the organism was also greater in animals with dual infections than in those infected only with Sporothrix. On the basis of this study, it appears probable that in certain istances fungi, as well as bacteria, may play an important role in transforming a mild subclinical case of lymphatic filariasis into a serious medical problem and that a filarial infection may greatly exacerbate an existing Sporothrix infection.

Animals↗
PubMed1975

Effect of diethylcarbamazine on third stage Brugia malayi larvae in cats.

Forty-one experimental and 37 control cats were each infected with 50 Brugia malayi larvae in such a way that a preponderance of the larvae remained localized in the popliteal lymph node or in the lymphatics of the leg draining into that node. During the 1st week after infection cats were treated with varying doses of diethylcarbamazine citrate (DEC). Two weeks after infection, necropsy for worm recovery was performed on treated and control cats. No living larva was recovered from 21 of 22 cats treated with a total of 10 mg DEC/kg body weight or greater. A single living larva was recovered in only 2 of 5 cats treated at 5 mg/kg. At 2 mg/kg, 8 of 10 cats had substantially fewer larvae than their controls; the remaining 2 were negative. In 4 cats treated with a total of 1 mg/kg, there was no reduction of larvae. All 37 untreated controls harbored living larvae, with a mean of 56% of the inoculum being recovered.

Brugia↗
PubMed1975

Distribution and development of Brugia malayi in reinfected cats.

At various time periods after an initial exposure to 50 Brugia malayi larvae on one hind foot cats were reexposed to an additional 50 larvae in one of 3 ways: on the previously infected limb only, on the contralateral, uninfected limb only, or on both hind limbs simultaneously. At the time of reexposure uninfected controls were exposed to 50 larvae on one hind foot in a similar manner. From 2 to 4 weeks after reexposure to larvae, the cats were necropsied and the appropriate lymph nodes and vessels examined for adult or developing worms. An existing infection in one limb did not influence early migration or development of larvae introduced into the contralateral leg. Previous infection in the same limb did not consistently result in decreases in the number of developing larvae from the second exposure but did alter the distrubution of larvae. In repeat infections, larvae were consistently located in a moe distal area of the limb than were larvae from an initial infection at a comparable time.

Animals↗