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Biomedical subjects

A Eskenasy

Publications and source records attributed to A Eskenasy.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

The systemic conception and its methods in pathology. Theses for a theoretical attempt.

A theoretical attempt concerning the use of the systemic conception and of its methods in pathology and in morphological research is presented in several theses. These bear on the systemic conception, the open informational biological systems, the structural analysis useful in biology and medicine, the possible development in the normal and pathological morphology. Some other theses are referred to: the pathological process as a whole and its features as a system formed by lesions and sequences, the internal and external relationships of pathological processes, the effects of different structural-organizational levels involved, the ensemble of determining factors, the stereotypes of pathological processes and the possibilities to influence them by the organismic mechanisms and by extrinsic interventions, including therapeutic ones. The relatively independent evolution of constituted pathological processes and its relationships with the integrating suprasystem (the organism) are also discussed.

Diagnosis↗
PubMedDate not supplied

Experimental aerogenic pulmonary berylliosis in rabbits.

The dynamics of pulmonary changes produced by a prolonged daily administration of 1 g per cent solution of BeSO4 in aerosols was pursued by current histopathological methods in periodically sacrificed rabbits. A progressive constitution of beryliosic granulomas involving intralobular and interlobular areas was observed. The epithelioids and giant cells were present in variable proportions. Concomitantly, a cellular thickening of alveolar walls and perivascular cuffs was noted, as well as an intercellular reticulin fibrillogenesis. The intratracheal three-fold administration of a 0.3 g per cent solution of BeSO4 induced a more rapid formation of berylliosic nodules with the same characters. The relation between the cell accumulation and reticulin fibrillogenesis was morphometrically analysed and statistically verified as pertinent correlated phenomena.

Aerosols↗
PubMedDate not supplied

The contemporary concept of alveolitis.

The concept of alveolitis as an exudative reaction dominated by plasma and cell accumulation within alveolar air spaces is reappraised in the light of new data concerning the reactional dynamics challenged by non-immune and immune agents vehiculated by air and blood ways, of the systemic approach of lung processes, of the consideration of alveolar walls and the air space delimited by them as a whole. The participation of alveolar mesenchymal cells and of blood cells and plasma in the development of alveolitis is obvious and the changes of alveolar walls are morphogenetically prevailing in time and space over those of air spaces, whose reactions represent only a secondary phase of the lung response. Both the primary parietoalveolar phase and the secondary air space phase form a whole reactional modality of the lung in which accumulative and proliferative, exudation and mobilization changes are highly interacting in the building up of alveolitis. The involved immune mechanisms may determine special cell accumulations, but the basic mechanism, the stereotype and the sequences of this reactional modality of the lung are not essentially different from the non-immune alveolar reactions.

Alveolitis, Extrinsic Allergic↗
PubMedDate not supplied

Experimental chronic obstructive lung disease. I. Bronchopulmonary changes induced in rabbits by prolonged exposure to formaldehyde.

The prolonged exposure to formaldehyde induces in the rabbit lung reactional and dystrophic changes involving the intrapulmonary bronchi, the bronchioli and the lung tissue. These changes are represented by bronchial cell hyperplasia with hypermucigenesis, extrusion of bronchial cells, bronchiolar hypermucigenesis, parcellary squamous metaplasia or necrobiosis of epithelia, thickening of bronchial and bronchiolar walls by subepithelial cell accumulations, destruction of musculo-elastic structures with stenosis or ectasia; the vascular reactions are hyperhaemic and proliferative with an obstructive and fibrous tendency; the parenchymal lesions are atelectasias, intralobular emphysema, and cellular thickening of alveolar walls and interlobular areas. The acid phosphatase, Tween-60-esterase, naphthol-AS-D-acetate-esterase, proline-oxidase and hydroxyproline-2-epimerase activities are increasing, while the leucyl-aminopeptidase and beta-glucuronidase ones are decreasing. The qualitative observations are completed and sustained by quanitative studies of mucous cell kinetics, of cell accumulations and differentiations.

Animals↗
PubMedDate not supplied

Pulmonary blastoma.

A case of pulmonary blastoma in a 8-year-old girl is reported. The histopathologic analysis evidenced carcinomatous tubes with several cell layers developing into a mesenchymal cell mass with undifferentiated elements forming a dendroreticulated network with minimal endothelial, fibroblastic and collagenous differentiations. The initial tumoral formation within the lower left lobe was rapidly followed after resection by a local recidive and nine months later by a voluminous metastatic formation within the upper left lobe, radiologically treated. Discussion of the histopathologic characteristics of this case supports the hypothesis of a peculiar neoplastic entity of the lung, in which only the epithelial component of the lung was involved, while the mesenchymal mass presented an unaffected fetal structure.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

The concept of chronic pathological processes.

The chronic pattern of lesions and the behaviour of each process as a whole, the internal relationships between sequences, the dynamics of factor assemblies determining the sequences and development of lesional chains, the propelling and cohesional factors are analysed in the morphopathogenic modalities of chronic processes, the chronic transformation of acute lesions and the primary chronic processes. This structural analysis lends support to the consideration of chronic pathological processes as systems and their investigation by the methods of the systemic conception applied to pathology. Key words: chronic pathological processes, chronic pattern of lesions, chronic transformation of acute lesions, primary chronic processes, sequential development, assemblies of factors, propelling factors, cohensional factors, proliferative dominance, self-perpetuation and auto-aggression mechanisms, stereotyping of chronic processes, systemic conception.

Animals↗
PubMedDate not supplied

Bronchiolo-alveolar cell carcinomas. A histopathologic analysis of 125 cases.

A hundred and twenty-five cases of bronchiolo-alveolar cell carcinomas observed between 1954 and 1978 were histopathologically analysed, some of them also histoenzymatically. The material comprised 93 lung resections (56 lobectomies and 37 pulmonectomies). 11 intraoperatory biopsies in inoperable cases, and 21 autopsies. The early discovery and treatment of the overwhelming majority of cases allow the observation of uncomplicated lesions, the bronchiolar involvement followed by alveolar invasion due to sliding of neoplastic cells on denuded alveolar walls often thickened by cell and fibril accumulation, the papillary formations, as well as the histoenzymatic behaviour. The latter evidenced the strong relations of neoplastic cells with the normal bronchiolar cells (glucose-6-phosphate dehydrogenase. Mg-dependent ATP-ase, oxidoreductases). Some peculiarities also point to the existence of a possible second parallel origin of neoplastic cells at the level of large alveolocytes during the morphogenesis of this multicentric lung carcinoma.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMedDate not supplied

Histoenzymology of the lung. V. Histoenzymatic analysis of sixty lung tumors.

A series of sixty lung tumors operated during 1977 were histoenzymatically investigated (12 macrocellular carcionomas, 4 microcellular, 18 epidermoid, 18 cylindrocubic, 2 bronchiolo-alveolar cell carcinomas, 4 lung fibroblastic sarcomas, and 2 benign lung tumors: a haemangioma and a carcinoid tumor). There were tested 25 enzymes, hydrolases and oxidoreductases of different metabolic pathways. The histoenzymatic analysis of the neoplastic lung tissue compared with the normal adult human lung tissue pointed to a shifting of the metabolic balance, with the decrease of enzyme activities belonging to the Krebs tricarboxylic acid cycle and with the increase or maintenance of the level of enzymic activities belonging to the Embden-Meyerhoff-Parnas pathway and to the pentose shunt. The enzymes intervening in the protidic activity in all the malignant tumors of the lung. Some hydrolases were also more active lung tissue pointed out the existence of close relations between the normal epithelia and the cylindrocubic and bronchiolo-alveolar types, and of distant ones with the epidermoid and microcellular carcinomas which suffered more accentuated ecogenetic influences (stopping of differentiation/maturation, metaplasia) during the complex oncogenetic process.

Adenocarcinoma, Bronchiolo-Alveolar↗