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Biomedical subjects

A Eskenasy

Publications and source records attributed to A Eskenasy.

At least 19 recordsLinked to original sources
PubMed1975

Morphogenesis and pathogenesis of chronic lung diseases. vii. Kinetics of alkaline phosphatase active cells during the development of experimental lung granulomas.

The circulating cells arriving at the formation site of the experimentally induced lung granuloma were quantitatively and qualitatively determined during their development by estimation of alkaline phosphatase active free cells. These represent 32 per cent the 2nd day and 27 per cent the 4th, of all the lung granuloma cells, and rapidly decrease to 8 per cent the 8th day, to 4 per cent the 11th and to only 1.5 per cent the 15th day. The participation of alkaline phosphatase circulating cells appears to be important only the first days, the process becoming by proliferation and differentiation a histiocytic, epithelioidic, and lympho-plasmocytic structure under the influence of antigenic and non-antigenic components of the used immunologic adjuvant.

Alkaline Phosphatase↗
PubMed1975

Kinetics of mucous cells in bronchial and bronchiolar epithelia during aerogenic elicitation with aspergillary proteins. A quantitative cytologic study.

During a prolonged exposure of rabbits to aerosols with asperigillary antigens, the content of bronchial and bronchiolar epithelia in mucus-secreting cells was quantified. In normals, the mucous cells do not exceed 3.2 per cent in bronchial epithelium and 0.44 per cent in bronchiolar one. After exposure, these proportions rapidly increase, after a primary discharge of goblet cells. The mucous cells become a majority after 7 exposures in bronchi and after 21 in bronchiolar epithelium. The maturation is more rapid in bronchioli than in bronchi. The secretion of neutral and acid mucopolysaccharides is early, concomitant in the same bronchus, and predominantly located in the impingement zones, especially the bifurcations of bronchial tree. The mitoses are extremely rare in exposed bronchi, but the epithelial and mesenchymal alveolar cells present a high mitotic index (1.14%) 24 hours after the second exposure to antigens.

Aerosols↗
PubMed1975

Morphogenesis and pathogenesis of chronic lung diseases. IX. Development of reticulinic fibrillogenesis during the evolution of an associated experimental silicosis and tuberculosis.

Well developed silicotic nodules of rabbit lungs were infected with tuberculosis and treated with tuberculostatics. The spatial evolution of lesions, as well as the density of intralesional and perilesional reticulinic fibrils were quantitatively analysed, measured by planimetric and target methods, and statistically analysed. Under tuberculostatics, the size of lesions, expressed in the dynamics of the SL/ST % ratio, rapidly diminished to half after three months. In the some period, the density of reticulinic fibrils expressed by the PA of the target method, increased, with significant differences between treated silicotuberculotic lesions and tuberculotic ones. The correlation analysis between these two divergent changes showed the interfering with other factors.

Animals↗
PubMed1975

Relationships between the lung mesenchymal cell populations: concurrent elicitation by air and blood ways of the lung reacting cell systems.

Some relationships between the lung reacting cell populations connected to the air and blood ways are investigated by elicitation with proteins in Freund's adjuvant and with SiO2. The agents were intratracheally and respectively intravenously injected into rabbits concomitantly or in different orders and times. The developmental analysis of the alveolar silicotic nodules and of the proteolipidic perivascular ones pointed out the involvement of both reacting cell systems in relation with the administration route, the involvement of local cells only, when the agent is less active and the arrival of blood mononuclears when the agent is more active. A concurrent taking part of the reacting cell systems in the process is demonstrated. The immune phenomena developed by both the used agents also elimine numerous cells from the formation process of nodules, and allow the production of hypersensitive reactions of the immediate and cellular type which influence the integrity and cellularity of formed nodules. The relationships between these two reacting cell systems of the lung appear to be not only quantitative but also qualitative.

Animals↗