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Biomedical subjects

A Enno

Publications and source records attributed to A Enno.

28 records · Page 2Linked to original sources
PubMed1990

A case of thrombotic thrombocytopenic purpura following allogeneic bone marrow transplantation.

A case of thrombotic thrombocytopenic purpura (TTP) is reported in a 40-year-old man 6 months after allogeneic bone marrow transplantation for multiple myeloma. The features of TTP included microangiopathic haemolytic anaemia, severe thrombocytopenia, fluctuating neurological abnormalities, and progressive renal impairment. Despite treatment with anti-platelet agents, prostacyclin infusion, intensive immunosuppression and prolonged plasma exchange, the patient developed end-stage renal failure and is now on maintenance haemodialysis 18 months after the onset of TTP. Graft-versus-host disease and cytomegalovirus infection could not be implicated as aetiological factors, and cyclosporin medication had ceased 1 week before the clinical onset of his disease. The unusually intensive pre-transplant chemotherapy and radiotherapy protocol used in this patient appear to be most likely cause of the generalized endothelial damage resulting in TTP in this patient.

Adult↗
PubMed1985

Flow cytometric enumeration of absolute lymphocyte number in peripheral blood using two parameters of light scatter.

A method was developed to measure the absolute lymphocyte count (ALC) of whole blood using the Spectrum III automated flow cytometer. Ninety-nine samples of human peripheral blood were analysed on the Spectrum and the Coulter Counter S Plus II, to allow for comparison of the two machines. Regression analysis was used to test the extent of agreement between the sets of measurements on the two machines. The results demonstrated that the slope of the regression line was not significantly different from one, indicating a high level of correlation between Spectrum and Coulter ALC's. However, the mean difference between Coulter and Spectrum ALC's was not equal to zero, with the Spectrum giving counts approximately 10% lower than those of the Coulter machine. This is attributed to the different ways by which the two machines define a lymphocyte, the Spectrum III by two parameters of light scatter and the Coulter S Plus II by the single parameter of cell volume.

Flow Cytometry↗
PubMed1982

Economic aspects of the prolonged fluoride application method.

Cost-benefit and cost-effectiveness analyses were carried out to obtain an indication of the economic viability of the prolonged fluoride application (PFA) method. Using three year results from a clinical trial of the technique, the cost-benefit ratio has calculated as 1:2.1 and the cost-effectiveness as $3.49 per surface saved in three years. For purpose of general comparison the same analyses were made for an alternative measure, the placement of pit and fissure sealants. Using data from a two-year sealant trial, the cost-benefit ratio was found to be 1:0.77 and the cost-effectiveness $18.49 per surface saved in two years. The findings indicated that the PFA method can be regarded as an economically viable procedure.

Child↗
PubMed1979

'Prolymphocytoid' transformation of chronic lymphocytic leukaemia.

We report clinical, morphological and surface marker studies on seven patients with the common type of chronic lymphocytic leukaemia (CLL) whose disease underwent an insidious though progressive change in character with increasing refractoriness to treatment. This transformation was accompanied by the appearance of a population of immature-appearing cells in the peripheral blood which resembled prolymphocytes, both at light and electron microscopy. The characteristic morphological feature was the presence of two distinct populations of cells, the typical CLL lymphocytes and the 'prolymphocytoid' cells. These cells retained the surface characteristics of CLL, i.e. the information of mouse RBC rosettes and sparse surface-bound immunoglobulin. This transformation can be distinguished by morphological and surface marker criteria from acute leukaemia occurring in CCL, Richter's syndrome and prolymphocytic leukaemia. The recognition of this group of CLL patients may add a new prognostic index to CLL and may help plan subsequent trials for the treatment of the disease.

Aged↗
PubMed1978

Co-trimoxazole for prevention of infection in acute leukaemia.

30 patients with acute leukaemia being treated with cytotoxic drugs were investigated in a randomised trial to determine whether oral administration of co-trimoxazole in addition to non-absorbable antibiotics would reduce the rate of infection. Three significant differences were observed between the co-trmoxazole and the control groups: (i) 15 of the 16 (94%) control patients but only 8 of the 14 (57%) patients on co-trimoxazole developed infections and required additional antibiotics intravenously; (ii) although the duration of severe neutropenia (neutrophils less than 0.1 times 10(9)/1) was similar in the two groups, control patients required intravenous antibiotics on average after 2 days of neutropenia, whereas patients receiving co-trimoxazole required these only after 12 days; and (iii) the only 2 patients who died of infection were in the control group. Prophylaxis with co-trimoxazole is important in preventing or delaying the development of infection in neutropenic patients receiving therapy for acute leukaemia.

Administration, Oral↗
PubMed1977

Morphological and cytochemical identification of lymphoid cells.

This paper reviews the contribution of light and electron microscopy, surface structure and cytochemistry (acid phosphatase, B-glucuronidase, alpha-naphthyl esterase, and PAS reactions) in the recognition and classification of normal and abnormal lymphocyte populations.

Acid Phosphatase↗
PubMed1976

Fluoride content of prepackaged fruit juices and carbonated soft drinks.

Epidemiological studies have established the beneficial effects of water fluoridation. Present dietary trends, however, indicate that many Australian children may consume more prepackaged fluids than actual tap water. The fluoride concentrations of a selection of carbonated soft drinks and prepackaged fruit juices were investigated. The results indicate that, in an optimal fluoride area such as Sydney, children who consume a consistent and large proportion of their fluids as carbonated soft drinks in cans, fruit juices and fruit drinks may not be receiving the full benefit of the water fluoridation.

Australia↗