Search PubMed⌕ Search

Biomedical subjects

A Engeset

Publications and source records attributed to A Engeset.

94 records · Page 6Linked to original sources
PubMedDate not supplied

Does serum protein binding inhibit tissue penetration of antibiotics?

Accumulated data on the penetration of 15 antibacterial agents into peripheral human lymph are reviewed. The major factor determining extravascular penetration is the level of serum protein binding. The penetration ratios of extravascular and serum levels diminish gradually as the level of protein binding increases. However, even at the highest protein-binding levels, distinct lymph concentrations are observed. The degree of penetration ranges from 100% for the antibiotic with the lowest level of serum protein binding (gentamicin, no drug bound) to 20% for that with the highest level of protein binding (flucloxacillin, 96% bound).

Anti-Bacterial Agents↗
PubMedDate not supplied

Changes in lymphoid cell distribution after intraperitoneal administration of 32P colloids.

The effect of intraperitoneal administration of 32P colloids on the distribution of T lymphocyte subpopulations and monocytes was studied using monoclonal antibodies and a flow cytometry technique. Thirty-nine patients with ovarian carcinoma without residual tumor after primary operation were examined either before the administration of 260 to 370 MBq of 32P, 4 to 6 days after therapy, or 4 to 10 months after therapy. A significant reduction of circulating OKT4+ (T helper) cells occurred after therapy, and the reduction lasted throughout the observation period. Monocyte numbers were not significantly changed. It is concluded that intraperitoneal instillation of the 32P isotope may induce the same type of changes in circulating lymphoid cells as those seen after external field irradiation.

Adult↗