Search PubMed⌕ Search

Biomedical subjects

A Emonot

Publications and source records attributed to A Emonot.

42 records · Page 3Linked to original sources
PubMedDate not supplied

[Interstitial pneumopathies caused by busulfan. Histologic, developmental and bronchoalveolar lavage analysis of 3 cases].

Busulfan-induced diffuse interstitial pneumonia is a rare but serious disease attributed to a direct toxic effect of busulfan (an alkylating antimitotic drug) on alveolar cells. We report three new cases explored by repeated bronchoalveolar lavages and lung biopsies. All patients had circulating immune complexes, abnormalities at capillaroscopy and above all lymphocytic or mixed alveolitis at bronchoalveolar lavage. The clinical outcome was favourable with regression of the alveolar lesions in the patient with pure lymphocytic alveolitis. It was unfavourable in patients showing severe alveolitis with polymorphonuclear cells. Histology revealed constant abnormalities of type I pneumocytes and rarefaction of type II pneumocytes, together with interstitial oedema and pulmonary fibrosis in which tissue mast cells could not be identified. The immunological disturbances observed in busulfan lung might enhance an initial toxic reaction and account for the often unfavourable outcome, even after withdrawal of busulfan.

Bronchoalveolar Lavage Fluid↗
PubMedDate not supplied

Bronchial carcinoids. A review of 22 cases.

This study investigated 22 patients with histologically proven primary bronchial carcinoids and in particular the relationship between assessment parameters and survival. In each patient, age, sex, smoking habits, mode of presentation, results of diagnostic investigations, methods of treatment and pathological examination of resected specimens were recorded. Follow-up was possible in all patients for at least 5 years. Patients with atypical carcinoids were 10 years older than patients with typical ones. Eleven patients were smokers, all the patients with atypical and 4 patients with typical carcinoid. The most common presenting mode was pneumonia. Fiberoptic bronchoscopy was diagnostic in 11 cases. The survival rate for patients with typical carcinoid was 100%, while it was 57% in patients with atypical carcinoids. Patients with limited disease had a survival of 100%, while in stage III/IV patients showed a lower survival rate (50%). In conclusion, carcinoid tumors of the lung are tumors showing a good prognosis. Five-year survival indicated a significant difference between typical and atypical carcinoids and between limited and extensive disease. A precise staging is recommended for a better treatment and follow-up.

Adolescent↗