[Beta-blockaders. Their pharmacology and clinical use].
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Biomedical subjects
Publications and source records attributed to A Elenkova.
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In 61 patients with chronic cor pulmonale with compensation and decompensation of circulation, the stroke and minute heart volume were studied as well as the indices, characterizing the blood-gas contents and acid-base blood state. The minute heart volume in the patients examined proved to be with normal values. Stroke heart volume is decreased in all patients examined with chronic cor pulmonale. The acceleration of heart activity enables the maintenance of normal minute volume. Hypoxemia has a cardiac depressive effect as regards minute volume and heart rate. The moderate hypercapnia has a certain stimulating effect on heart. A direct proportional correlation exists between the hypercapnia degree and the tendency of minute volume increase and especially of heart rate. The campaign against hypoxemia is an essential element in the prophylaxis and early treatment of chronic cor pulmonale.
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The basic hemodynamic indices were determined in 50 diabetics by the method of dye-dilution. Changes in heart-capacity were established as well as an increase in plasma and blood volume decrease in blood flow speed and a tendency towards decrease of functional fitness of the cardiovascular system. The mentioned changes are associated with diabetes mellitus duration, with the presence of diabetic microangiopathy, diabetic nephroapathy, coronary disease, etc. The existing arterial hypertension effects hemodynamics especially unfavourably. In patients with diabetes and acidoketosis hyperkinetic type of circulation is found with decrease of the cardiovascular system functional fitness.
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