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Biomedical subjects

A Eid

Publications and source records attributed to A Eid.

108 records · Page 6Linked to original sources
PubMed1989

[An epidemiologic survey of caries frequency and periodontal status in children 6 to 15 years of age in 11 provincial regions in central France, Bourgogne and the Ile de France].

An epidemiological survey of dental caries and periodontal conditions was conducted on 2,022 children in eleven french "departments" of Center of France and part of Bourgogne and lle de France. It showed a dft of 3.03 and dfs of 4.83 at the age of 6 years, as well as an increasing DMFT from 0.65 at the age of 6 to 7.26 at the age of 15. The DMFS increased from 0.91 at 6 years to 12.31 at the age of 15. The calculus index increased steadily from 0.14 at the age of 6 to 0.64 at the age of 15. The gingival index increased from 0.27 in the 6 year old, to 0.55 in the 15 year old.

Adolescent↗
PubMed1988

Induction of transplantation tolerance by intraportal injection of allogeneic bone marrow cells. Possible implications for intrauterine bone marrow transplantation across major histocompatibility barriers.

Intraportal inoculation of C57BL/6 marrow cells into sublethally (400 rad) irradiated BALB/c recipients resulted in durable chimerism and the permanent acceptance of C57BL/6 skin allografts. Sublethally irradiated recipients of a similar number of marrow cells inoculated systemically did not develop chimerism or any significant prolongation of the survival of C57BL/6 skin allografts. Consequently, lethal graft-versus-host disease developed only in recipients of intraportal marrow allografts (80%). The intraportal injection of allogeneic C57BL/6 marrow cells into nonirradiated recipients resulted in significant, although not permanent, prolongation of skin allograft survival without durable chimerism, suggesting that the introduction of alloantigens intraportally may favor the induction of nonresponsiveness to alloantigens even across strong major histocompatibility barriers. The relevance of these findings is discussed regarding the intraportal inoculation of allogeneic bone marrow cells for the treatment of genetic disorders in utero through the induction of neonatal tolerance.

Animals↗
PubMed1988

The relationship between dietary fat, adipose tissue composition, and neoplasms of the breast.

Dietary fat has been implicated in the development of carcinoma of the breast. Because of the difficulties in obtaining accurate dietary histories, we analyzed subcutaneous adipose fatty acids to compare the quality of fat intake in three groups of patients undergoing investigations for breast masses. These included carcinoma (n = 37, avg. age 54 yrs.), fibroadenoma (n = 27, age 31 yrs.), and other types (n = 21, age 50 yrs.). Subjects in the carcinoma group were heavier, although they were not obese. A one-way analysis of variance of nine adipose fatty acids and their derived ratios [polysaturates:saturates (P:S)] did not show any systematic differences in the three groups. The quality of dietary fat does not appear to be associated with the development of neoplasia of the breast in this population, which consumes a diet of a high P:S ratio.

Adenofibroma↗
PubMed1987

Alloantigen persistence in induction and maintenance of transplantation tolerance.

Infusion of parental bone marrow cells into F1 hybrids conditioned by total lymphoid irradiation (TLI) results in chimeras with a high percentage of donor-type cells, and without clinical signs of graft-vs.-host reaction. In these chimeras, a state of tolerance has been shown to be associated with paucity of cytotoxic T lymphocyte percursors (pCTL) reactive with host-type alloantigens. To determine whether the presence of tolerizing alloantigens is essential for maintenance of unresponsiveness, lymphohematopoietic cells obtained from such tolerant chimeras were transferred into supralethally irradiated recipients of two different genotypes: in one case the adoptive recipients were syngeneic with host-type cells, and in the other they were syngeneic with donor-type cells of the original chimeras, thus providing the chimeric cells with a tolerogen-free environment. After "parking" for 4 d in syngeneic donor-type mice, the transferred cells displayed a marked increase in the frequency of pCTL directed against tolerizing alloantigens, whereas a low pCTL frequency directed against the same H-2 target cells was maintained in allogeneic tolerizing-type adoptive recipients. Multiple injections of adoptive donor-type mice with tolerizing-type cells of the original chimera reestablished a low level of cytotoxic precursors. Cytotoxic activity against unrelated alloantigens was independent of the presence of tolerogen-presenting cells in the adoptively transferred mice. Our experimental model suggests that persistence of cells bearing tolerizing alloantigens is an essential requirement for maintenance of previously established tolerance.

Animals↗
PubMed1987

Noma in an unusual case of perforated appendicitis with pneumoperitoneum.

Noma is a very rare gangrenous infection of the oral cavity usually associated with debilitating diseases, immunosuppression, or malnutrition. Its development in a previously healthy 13-year-old boy with perforated appendicitis is presented. Streptococcus bovis type II and E coli were isolated from the noma and Streptococcus bovis, Bacteroides fragilis, and Bacteroides asacharolyticus from the peritoneal fluid. A transient impaired immune cellular function was found and may have contributed to the development of the noma in this child.

Adolescent↗
PubMed1984

Pericardial tamponade complicating central venous catheterization in a newborn infant.

Complications of central venous catheterizations are divided into immediate or early complications such as haematoma, pneumothorax and haemothorax, and late complications such as infection and venous thrombosis. One of the rare but life-threatening complications of central venous catheterization is pericardial tamponade. We review the literature and add an additional case, the first reported in a newborn infant.

Cardiac Tamponade↗
PubMed1983

An unusually high incidence of gastrointestinal obstruction by persimmon bezoars in Israeli patients after ulcer surgery.

Seventy-seven patients presented with gastrointestinal obstruction due to phytobezoars during a 5-mo period. Most of the patients (88.3%) had a history of persimmon ingestion, and all had previous surgery for ulcer disease. Seventy-one patients were treated surgically; 67 because of intestinal obstruction and 4 for extraction of gastric phytobezoars. Five patients were reoperated once and 1 patient twice because of retained phytobezoars. Six patients were treated conservatively. Seventy-five patients recovered after surgical or conservative therapy, and 2 patients died. Patients who have undergone gastric surgery should be warned about the risk of persimmon ingestion.

Adolescent↗
PubMedDate not supplied

Gastrointestinal involvement in homocystinuria.

Homocystinuria is frequently associated with severe multisystem involvement such as dislocated lenses, skeletal deformities, mental retardation and premature vascular occlusions. Surprisingly, gastro-intestinal involvement has not been described in this disorder. We present a 17 year old boy with homocystinuria due to cystathionine beta-synthase deficiency, who developed severe gastrointestinal involvement, manifested by chronic diarrhoea and acute pancreatitis. The diarrhoea was successfully treated with betaine. Possible pathophysiological mechanisms and suggested treatment are described.

Adolescent↗
PubMedDate not supplied

Severe thrombotic complications associated with activated protein C resistance acquired by orthotopic liver transplantation.

We report a patient who developed recurrent hepatic artery thrombosis and deep venous thrombosis following orthotopic liver transplantation. Investigations revealed the presence of activated protein C (APC) resistance due to a mutation in the factor V gene in the transplanted liver. The patient's own peripheral blood cells did not carry the mutation. Although part of factor V is located in the platelets and may be endogenously synthesized by megakaryocytes, this case demonstrates the major clinical importance of hepatic-derived factor V. It may be reasonable to screen liver donors with a history of a thrombotic event for APC, and to consider anticoagulation in the recipients of livers positive for this defect.

Activated Protein C Resistance↗
PubMedDate not supplied

Complications from supervised mask use in post-operative surgical patients during the Gulf War.

This is a report of three patients in a surgical ward of a hospital who developed complications seemingly related to the use of full-face-fitting masks associated with the first Scud Missile attack on Israel during the Gulf War. Patient 1 developed atrial fibrillation with an uncontrolled ventricular rate; Patient 2 redeveloped a gastrointestinal hemorrhage; and Patient 3 developed a severe anxiety attack. Each of the three was severely ill prior to the event. Special attention should be given to severely ill patients during such events.

Adult↗
PubMedDate not supplied

Practice and theory of "delayed" embolectomy. A 22-year perspective.

A study was made of delayed embolectomy in 45 patients (55 limbs). In 5 patients (11%) the cause of arterial embolization was rheumatic heart disease, and 40 patients (89%) suffered from atherosclerotic cardiovascular disease. The study was divided into 3 phases: I (1960-1964), II (1965-1974) and III (1975-1981). In phases II and III surgery was carried out using the Fogarty catheter technique. In 5 patients the embolus was located in the upper extremity. Seven patients died and 8 major amputations were performed within 30 days of surgery. Use of the Fogarty catheter technique and persistent anticoagulant therapy effected 71.8% limb salvage in phase II and 91.6% limb salvage in phase III. Successful revascularization was achieved in 70.9% of the limbs in which peripheral emboli had occurred on an average of 2.7 days prior to surgical intervention. A theoretical basis for the late development of the acute embolic onset is presented.

Adult↗