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Biomedical subjects

A Ebel

Publications and source records attributed to A Ebel.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Changes in cholinergic mechanisms and in learning in three strains of inbred mice after electric stimulation of the dorsal hippocampus].

Two experiments investigated the neurochemical correlates of hippocampal stimulation effects on learning in three inbred strains of Mice. In the 1st experiment, it was shown that subseizure electrical stimulation of the dorsal hippocampus, 30 sec. after a partial appetitive learning session (1) improved 24 hrs. delayed performances of BALB/c Mice (2) had little but significant effect on C57BL/6 (3) had no effect on C57BR animals. The second experiment was aimed at studying the stimulation effect on hippocampal cholinergic mechanisms by testing the two main enzymes involved in acetylcholine synthesis and degradation (choline acetyltransferase = ChAc and acetylcholinesterase = AChE). The major findings of this experiment were as follows: (1) stimulation induced a 3 hrs. delayed improvement of ChAc activity for the BALB/c strain (2) a similar but less important effect was observed in C57BL/6 Mice (3) there was no effect for C57BR animals. These result further support the view that cholinergic hippocampal mechanisms act upon memory consolidation.

Acetylcholinesterase↗
PubMed1976

The (Na+ + K+)-ATPase activity in brain of Quaking mice.

The (Na+ 4 K+)- and Mg2+-dependent ATPase distribution in several brain areas has been investigated in Quaking mutant mice characterized by myelin deficiency. A marked decrease of (Na+ + K+)-ATPase activity has been found in limbic structures, hypothalamus and cerebellum. The Mg2+-dependent activity did not change. A possible involvement of the impairment of the (Na+ + K+)-ATPase activity in the seizure susceptibility of this mice is discussed.

Adenosine Triphosphatases↗
PubMed1976

The role of hippocampal cholinergic mechanisms in the aquisition of a barpress response.

The role of hippocampal cholinergic mechanisms in learning a bar-press response reinforced with food was investigated. Firstly, an interstrain comparison showed that mice having a low choline acetyltransferase activity in the dorsal hippocampus were quicker to associate the barpress with reinforcement. Secondly, when the activity of this enzyme was reduced by a subseizure electrical stimulation of the hippocampus learning was accelerated. It is suggested that acetylcholine availability at the hippocampal synapses slowed the apparition of these learned responses.

Acetylcholinesterase↗