Improved sampling system for mass spectrometric measurement of water vapour pressure.
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Humans↗
Biomedical subjects
A E Vedig
Publications and source records attributed to A E Vedig.
Deaths in intensive care: analysis and prediction.
Analysis of the data relating to the most critically ill (grade IV) patients admitted to the intensive care unit at Flinders Medical Centre in 1977 and 1978 has been carried out. The mortality rate in this group was 37% in 1977, and 32% in 1978. No absolute predictors of outcome were found, indicating the need for early aggressive investigation and management of critically ill patients. The disease state, and the presence of coma or renal failure, were useful guides to prognosis. Cardiovascular system failure was the cause of death in 51% of patients, and central nervous system failure the cause of death in 28% of patients. Comparison with other published results was difficult because of the lack of standard methods of data reporting. Maintenance of life support was ceased in 28 patients, 15 of whom did not have brain death. Criteria for making such a decision are proposed.
Acute Kidney Injury↗
Metabolic and cardiovascular side effects of the beta 2-adrenoceptor agonists salbutamol and rimiterol.
The metabolic and cardiovascular side-effects of intravenous infusions of therapeutic doses of beta 2-adrenoceptor agonists salbutamol and rimiterol have been determined in four healthy male subjects. There were dose-related increases in plasma glucose, renin activity, serum insulin and heart rate, and significant hyperlactataemia and ketonaemia. There were dose-related decreases in plasma potassium, phosphate and corticosteroids and significant hypocalcaemia and hypomagnesaemia. The effects of equivalent molar amounts of salbutamol and rimiterol were similar. Whichever drug is used, special care is required with patients who may have abnormal glucose tolerance, potassium depletion, or be predisposed to lactic acidosis. Rimiterol may be preferable for infusion because of its short plasma half-life.
Albuterol↗
Compartmental shift of potassium--a result of sympathomimetic overdose.
A 17-year-old youth was admitted with a serum potassium concentration of 1.8 mmol/l after taking an overdose of pseudoephedrine and choline theophyllinate. Apart from tachycardia, tachypnoea and ankle clonus, examination was normal as was the initial electrocardiograph. The hypokalaemia resolved, but there was an overall positive potassium balance of only 13 mmol. This suggests that the sympathomimetics provoked a compartmental shift of potassium perhaps indirectly by inducing hyperglycaemia and hyperinsulinaemia, as well as directly. Other factors known to affect body potassium distribution were excluded. The fact that features commonly associated with hypokalaemia could not be demonstrated may be explained by a normal body potassium content. Severe hypokalaemia caused by a compartmental shift occurs with large doses of sympathomimetics as well as in periodic paralysis.
Adolescent↗