Search PubMed⌕ Search

Biomedical subjects

A E Treloar

Publications and source records attributed to A E Treloar.

14 recordsLinked to original sources
PubMed1981

Menstrual cyclicity and the pre-menopause.

The phase of menstrual life in which transition occurs from relatively regular cycles to the termination defined as menopause is studied for several hundred women who have kept accurate records of their menstrual flows. Age at both natural and oestrogenic menopause, age upon entry into the menopausal transition, and duration of that transition are analysed quantitatively. Detection of entry into the pre-menopausal phase is discussed. A complication of reactions to climacteric discomforts as recorded voluntarily by the study participants is presented.

Adolescent↗
PubMed1981

Spontaneous abortion over time: comparing occurrence in two cohorts of women a generation apart.

A prospective study of menstrual cycles and reproductive outcomes has been in progress since 1935. Data from this study are used to describe the risk of spontaneous abortion in two time periods 26 years apart. Out of the total of 3889 women who have enrolled in this study, two cohorts of women are selected for analysis: cohort one consists of 2070 university students who entered the study in 1935-1944, and cohort two consists of 1375 students a generation later, 1961-1970. Cohort one has contributed 2408 pregnancies, and cohort two, 1493 pregnancies. Overall spontaneous abortion risk for the two cohorts is 16.9% and 13.1%, respectively. However age-specific risks of spontaneous abortion do not differ for the two groups, nor is there a difference in the gestational duration of spontaneously aborted pregnancies.

Abortion, Spontaneous↗
PubMed1979

Probability of menopause with increasing duration of amenorrhea in middle-aged women.

The empirical percent probability that natural menopause has occurred after first presentation of amenorrhea of various durations in women greater than or equal to 45 years of age has been calculated using data from a cohort of subjects who prospectively recorded menstrual flow and related gynecologic events. The probability that menopause has occurred increases with the amenorrheal interval (duration), and for a given interval, the probability increases with age. After 180 days of amenorrhea, 45% to 72% of subjects were menopausal; after 360 days, 90%. These data may offer assistance in advising patients on the probability of menopause and the continuance of contraceptive practices, and in considering whether late genital bleeding after amenorrhea represents a physiologic or pathologic process.

Age Factors↗
PubMed1978

Menstrual cycle patterns and breast cancer risk factors.

Using a data set of women who longitudinally recorded menstrual and reproductive events, we examined menstrual cycle characteristics in relationship to early and late menarche, early and late menopause, and deferred parity, three variables epidemiologically related to breast cancer incidence. Women with late onset of menarche had longer and more variable cycles in the 10 years after menarche than did those with early onset. Women with late onset of menopause had longer and more variable cycles in the premenopausal interval than did those with early onset. Cumulative fertility in women after marriage did not differ according to cycle length and variance. Late menopause may be a breast cancer risk factor due to relative estrogen excess and progesterone lack as reflected in longer, more varied cycle patterns. Observed cycle differences between women with early and late menarche await further study of the endocrine physiology of the menstrual cycle in those groups.

Adolescent↗
PubMed1977

Changes in menstrual cycle length and regularity after use of oral contraceptives.

This is an analysis of changes in menstrual cycle length and regularity occurring for a group of 211 women who had discontinued use of oral contraceptives. The analysis is based on prospectively recorded histories from the Menstruation and Reproduction History Program. Post-pill menstrual cycle length and regularity are compared with pre-pill averages. In the first post-pill cycle, there was an average increase of 6 days in cycle length. In subsequent cycles, however, cycle length and regularity were comparable to pre-pill norms in most cases.

Adult↗
PubMed1977

The risk of post-pill amenorrhea: a preliminary report from the Menstruation and Reproduction History Research Program.

Menstrual cycle lengths prior to and after oral contraceptive use were prospectively recorded for 245 women. In this preliminary study, a difference in the distributions in the pre- and post-pill cycle lengths was observed. An increase of 5 days in the medial cycle length occurred after oral contraceptive use had been discontinued. Although there was an approximately twofold relative risk of amenorrhea of 90 days' duration or more after discontinuing pill use, the differences in the rates of amenorrhea between the pre-pill and post-pill cycles were not statistically significant.

Adult↗